Antiproliferative Effects of Snake Venom Phospholipases A2 and Their Perspectives for Cancer Treatment

Osipov, Alexey V.; Utkin, Yuri N.

doi:10.1007/978-94-007-6452-1_13

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Therefore, the initiation of the cell death signaling cascade could be caused by the activation of a transmembrane receptor. Evidence suggests the interactions of the C-terminal region of svPLA 2 s with these receptor types (i.e., integrins and growth-factor receptors), and these interactions may be related to the triggering of death in tumor cells [8,[18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…However, the antitumor effect of svPLA 2 seems to be independent of its catalytic activity. Instead, the possibility of a selective effect against cancer cells mediated through C-terminal region electrostatic interactions with cytoplasmic membrane components such as cell proliferation receptors, cell death receptors, or extracellular matrix (ECM) adhesion integrins has been postulated [8,10,14,[18][19][20][21][22]. Another mechanism, demonstrated by Massimino et al, involves the interaction of a Lys49 svPLA 2 from Bothrops asper with cell membrane nucleolin, which subsequently mediates the cellular enzymes' internalization [23].…”

Section: Introductionmentioning

confidence: 99%

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Pllans−II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways

Montoya-Gómez,

Tonello,

Spolaore

et al. 2023

Cells

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Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans−II, a phospholipase A2 type-Asp49 from Porthidium lansbergii lansbergii snake venom, has shown selective attack against the HeLa and Ca Ski cervical cancer cell lines. This work suggests that the cytotoxic effect generated by Pllans−II on HeLa cells is triggered without affecting the integrity of the cytoplasmic membrane or depolarizing the mitochondrial membranes. The results allow us to establish that cell death in HeLa is related to the junction blockage between α5β1 integrins and fibronectin of the extracellular matrix. Pllans−II reduces the cells’ ability of adhesion and affects survival and proliferation pathways mediated by intracellular communication with the external environment. Our findings confirmed Pllans−II as a potential prototype for developing a selective chemotherapeutic drug against cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pllans−II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways

Montoya-Gómez,

Tonello,

Spolaore

et al. 2023

Cells

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Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential

Silva

Gonçalves

Marques

2022

CDT

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: The emergence of multi-drug resistant bacteria and limitations on cancer treatment represent two important challenges in modern medicine. Biological compounds have been explored with particular focus on venoms. Although they can be lethal or cause considerable damage to humans, venom is also a source rich in components with high therapeutic potential. Viperidae family is one of the most emblematic venomous snake families and several studies highlighted the antibacterial and antitumor potential of viper toxins. According to the literature, these activities are mainly associated to five protein families – svLAAO, Disintegrins, PLA2, SVMPs and C-type lectins- that act through different mechanisms leading to the inhibition of the growth of bacteria, as well as, cytotoxic effects and inhibition of metastasis process. In this review we provide an overview of the venom toxins produced by species belonging to the Viperidae family, exploring their roles during the envenoming and their pharmacological properties, in order to demonstrate its antibacterial and antitumor potential.

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Natural Products: Implication in Cancer Prevention and Treatment through Modulating Various Biological Activities

Anwar

Almatroudi

Alsahli

et al. 2020

ACAMC

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: Cancer is one of the most leading causes of deaths worldwide. It is one of the primary global diseases that cause morbidity and mortality in millions of people. It is usually caused by different carcinogenic agents that damage the genetic material and alter the cell signaling pathways. Carcinogens are classified into two groups as genotoxic and nongenotoxic agents. Genotoxic carcinogens are capable of directly altering the genetic material, while the non-genotoxic carcinogens are capable of producing cancer by some secondary mechanisms not related to direct gene damage. There is undoubtedly a greatest need to utilize some novel natural products as anticancer agents, as these are within reach everywhere. Interventions by some natural products aimed at decreasing the levels and conditions of these risk factors can reduce the frequency of cancer incidences. Cancer is conventionally treated by surgery, radiation therapy and chemotherapy but such treatments may be fast-acting, but causes adverse effects on normal tissues. Alternative and innovative methods of cancer treatment with the least side effects and improved efficiency are being encouraged. In this review, we discuss the different risk factors of cancer development, conventional and innovative strategies of its management and provide a brief review of the most recognized natural products used as anticancer agents globally.

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Antiproliferative Effects of Snake Venom Phospholipases A2 and Their Perspectives for Cancer Treatment

Cited by 3 publications

References 46 publications

Pllans−II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways

Pllans−II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways

Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential

Natural Products: Implication in Cancer Prevention and Treatment through Modulating Various Biological Activities

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