Antiproliferative efficacy of the antioxidant bioactive compounds of defatted seeds of<i>Azadirachta indica</i>and<i>Momordica charantia</i>against the regulatory function of tumor suppressor gene inducing oral carcinoma

Sharma, Yash; Kaur, Amritpal; Mishra, Rupa; Kulkarni, Sharvari; Bharadwaj, Mausumi; Bala, Kumud

doi:10.1080/07391102.2022.2083015

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…Assessment of antioxidant effect of AgAPE (Sox) and AgAPE (Mac) on Hep2C and KB cells was evaluated using the standardized protocol for estimation of enzymatic activities i.e., superoxide dismutase (SOD), catalase (CAT), Glutathione-S-Transferase (GST) and non-enzyme content i.e., Glutathione content (GSH) and lipid peroxidation (Malondialdehyde (MDA) content) 68 .…”

Section: Methodsmentioning

confidence: 99%

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Kaur,

Sharma,

Singh

et al. 2023

Sci Rep

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Biogenic silver nanoconjugates (AgNCs), derived from medicinal plants, have been widely explored in the field of biomedicines. AgNCs for the first-time were synthesized using ethyl acetate seed extracts of Abrus precatorius and their antiproliferative and antiangiogenic efficacies were evaluated against cervical and oral carcinoma. Ultraviolet–Visible spectrophotometry, dynamic light Scattering (DLS), and scanning electron microscopy (SEM) were used for characterization of AgNCs. Antiproliferative activity was investigated using MTT, DNA fragmentation and in-vitro antioxidant enzyme activity assays. In-vivo chick chorioallantoic membrane (CAM) model was used to evaluate antiangiogenic activity. A total of 11 compounds were identified in both the extracts in GCMS analysis. The synthesized AgNCs were spherical shaped with an average size of 97.4 nm for AgAPE (Sox) and 64.3 nm for AgAPE (Mac). AgNCs possessed effective inhibition against Hep2C and KB cells. In Hep2C cells, AgAPE (Mac) revealed the highest SOD, catalase, GST activity and lower MDA content, whereas AgAPE (Sox) showed the highest GSH content. On the other hand, in KB cells, AgAPE (Sox) exhibited the higher SOD, GST activity, GSH content, and least MDA content, while AgAPE (Mac) displayed the highest levels of catalase activity. Docking analysis revealed maximum binding affinity of safrole and linoleic acid with selected targets. AgAPE (Sox), AgAPE (Mac) treatment profoundly reduced the thickness, branching, and sprouting of blood vessels in the chick embryos. This study indicates that A. precatorius-derived AgNCs have enhanced efficacies against cervical and oral carcinoma as well as against angiogenesis, potentially limiting tumour growth.

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Section: Methodsmentioning

confidence: 99%

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Kaur,

Sharma,

Singh

et al. 2023

Sci Rep

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“…Srinivasan et al demonstrated that the treatment of green tea polyphenols declined the number of tumors, tumor volume, and OSCCs in 4-nitroquinoline-1-oxide -induced rats [119]. Sharma et al reported that the polyphenolic flavonoids found in defatted seeds of Azadirachta indica and Momordica charantia exhibited antiproliferative activity against Human oral epidermal carcinoma KB cells [120]. A study by King et al showed the dose-dependent inhibition of cellular proliferation in OSCC cells with grape seed PAC.…”

Section: Polyphenols and Oral Cancermentioning

confidence: 99%

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Guo,

Li,

Chen

et al. 2023

Nutrients

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Polyphenols, a class of bioactive compounds with phenolic structures, are abundant in human diets. They have gained attention in biomedical fields due to their beneficial properties, including antioxidant, antibacterial, and anti-inflammatory activities. Therefore, polyphenols can prevent multiple chronic or infectious diseases and may help in the prevention of oral diseases. Oral health is crucial to our well-being, and maintaining a healthy oral microbiome is essential for preventing various dental and systemic diseases. However, the mechanisms by which polyphenols modulate the oral microbiota and contribute to oral health are still not fully understood, and the application of polyphenol products lies in different stages. This review provides a comprehensive overview of the advancements in understanding polyphenols’ effects on oral health: dental caries, periodontal diseases, halitosis, and oral cancer. The mechanisms underlying the preventive and therapeutic effects of polyphenols derived from dietary sources are discussed, and new findings from animal models and clinical trials are included, highlighting the latest achievements. Given the great application potential of these natural compounds, novel approaches to dietary interventions and oral disease treatments may emerge. Moreover, investigating polyphenols combined with different materials presents promising opportunities for developing innovative therapeutic strategies in the treatment of oral diseases.

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Effective seed cake extract of O. sanctum inducing the p53 dependent apoptotic pathway in oral cancer cells

Sharma,

Mishra,

Kaur

et al. 2023

Drug Development and Industrial Pharmacy

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Antiproliferative efficacy of the antioxidant bioactive compounds of defatted seeds ofAzadirachta indicaandMomordica charantiaagainst the regulatory function of tumor suppressor gene inducing oral carcinoma

Cited by 5 publications

References 36 publications

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies

Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

Effective seed cake extract of O. sanctum inducing the p53 dependent apoptotic pathway in oral cancer cells

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