Antiproliferative potentials of chitin and chitosan encapsulated gold nanoparticles derived from unhatched Artemia cysts

Panneer, Devendrapandi Santhana; Thirunavukkarasu, Subramani; Sadayandi, Vivekanandan; Rajendiran, Nagappan; Mohammad, Faruq; Oh, Won-Chun; Sagdevan, Suresh

doi:10.1016/j.cplett.2022.139345

Cited by 6 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitin, as an appropriate carrier, can be used to deliver AgNP in addition to its anti-cancer properties by inhibiting anti-apoptotic genes [ 58 ]. Chitin and chitosan, as safe biological sources, can both be effective in treating cancer by drug delivery and have been shown to have anti-proliferative effects in some human cancers, including colon and lung cancers, which are two of the most common cancers in the world [ 59 , 60 , 61 ]. Colon cancer is the third most common cancer in the American population, and chemotherapy, known as a promising therapy, faces problems such as increased resistance to chemotherapy drugs [ 62 ].…”

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

“…Colon cancer is the third most common cancer in the American population, and chemotherapy, known as a promising therapy, faces problems such as increased resistance to chemotherapy drugs [ 62 ]. In a study by Santhana Panneer et al, chitin was extracted from Artemis cysts, chitin and chitosan-loaded gold nanoparticles were prepared, and their anti-cancer properties were evaluated in two common colon and lung cancers, HT-29 and A549 cell lines, respectively [ 59 ]. Their experiments showed that both chitin- and chitosan-based Au nanoparticles could reduce the viability of colon and lung cancer cells, and the percent viability reduction also depended on the concentration of nanoparticles [ 58 ].…”

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

“…Their experiments showed that both chitin-and chitosan-based Au nanoparticles could reduce the viability of colon and lung cancer cells, and the percent viability reduction also depended on the concentration of nanoparticles [58]. Essentially, Au+ ions inhibit cell viability by triggering the oxidative stress response in cells, which in turn leads to DNA damage and apoptosis [59]. In an effort to find suitable carriers for cancer therapy, Vijayakumar et al extracted chitin from shrimp shells to stabilize silver nanoparticles (AgNP) and to treat human hepatocellular carcinoma [58].…”

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

See 3 more Smart Citations

Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing

2022

View full text Add to dashboard Cite

Chitin and its derivative chitosan are highly abundant polymers in nature, appearing in both the shells and exoskeletons of various marine and non-marine species. Since they possess favorable properties, such as biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, they have gained recent attention due to their enormous potential biomedical applications. The polycationic surface of chitosan enables it to form hydrogenic and ionic bonds with drug molecules, which is one of its most useful properties. Because chitosan is biocompatible, it can therefore be used in drug delivery systems. The development of chitosan-based nanoparticles has also contributed to the significance of chitin as a drug delivery system that can deliver drugs topically. Furthermore, chitin can be used in cancer treatment as a vehicle for delivering cancer drugs to a specific site and has an antiproliferative effect by reducing the viability of cells. Finally, chitosan can be used as a wound dressing in order to promote the faster regeneration of skin epithelial cells and collagen production by fibroblasts. As discussed in this review, chitin and chitosan have diverse applications in the medical field. Recognizing the biomedical applications of these two polymers is essential for future research in tissue engineering and nanobiotechnology.

show abstract

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

Section: Application Of Chitin and Chitosan In Cancer Therapymentioning

confidence: 99%

See 2 more Smart Citations

Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing

2022

View full text Add to dashboard Cite

show abstract

“…24 Chitin based drug carrier has demonstrated noteworthy antiproliferative effects against colon and lung cancers. 25 In addition, chitin has also been investigated for delivering antibiotics and antifungal agents to treat infectious diseases. 26 In agriculture, chitin along with its derivatives like chitosan, has gained considerable attention and demonstrated extensive applications in the fight against plant diseases.…”

Section: Introductionmentioning

confidence: 99%

Comparing the antibacterial activity of chitin nanocrystals with chitin: exploring the feasibility of chitin nanocrystals as novel pesticide nanocarriers in agriculture

Xiang,

Zhang,

Cao

et al. 2023

Pest Management Science

View full text Add to dashboard Cite

BACKGROUNDIn recent years, nanomaterials‐based pesticide carriers have garnered significant attention and sparked extensive research. However, most studies have primarily focused on investigating the impact of physical properties of nanomaterials, such as size and modifiable sites, on drug delivery efficiency of nano‐pesticides. The limited exploration of biologically active nanomaterials poses a significant obstacle to the advancement and widespread adoption of nano‐pesticides. In this study, we prepared chitin nanocrystals (ChNC) based on acid hydrolysis and systematically investigated the differences between nano‐ and normal chitin against plant bacteria (Pseudomonas syringae pv. tabaci). The primary objective was to seek out nanocarriers with heightened biological activity for the synthesis of nano‐pesticides.RESULTSZeta potential analysis, Fourier Transform infrared spectrometry (FTIR), X‐Ray diffraction (XRD), Atomic force microscopy (AFM) and Transmission electron microscopy (TEM) identified the successful synthesis of ChNC. ChNC showcased remarkable bactericidal activity at comparable concentrations, surpassing that of chitin, particularly in its ability to inhibit bacterial biofilm formation. Furthermore, ChNC displayed heightened effectiveness in disrupting bacterial cell membranes, resulting in the leakage of bacterial cell contents, structural DNA damage, and impairment of DNA replication. Lastly, potting experiments revealed that ChNC is notably more effective in inhibiting the spread and propagation of bacteria on plant leaves.CONCLUSIONChNC exhibited higher antibacterial activity compared to chitin, enabling efficient control of plant bacterial diseases through enhanced interaction with bacteria. These findings offer compelling evidence of ChNC's superior bacterial inhibition capabilities, underscoring its potential as a promising nanocarrier for nano‐pesticide research.This article is protected by copyright. All rights reserved.

show abstract

Valorizing shrimp shell chitosan: a versatile biomaterial for fabricating effective antibacterial and antioxidant silver nanoparticles

Aouadi,

Saoud,

Rebiai

et al. 2024

J Sol-Gel Sci Technol

View full text Add to dashboard Cite

Antiproliferative potentials of chitin and chitosan encapsulated gold nanoparticles derived from unhatched Artemia cysts

Cited by 6 publications

References 40 publications

Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing

Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing

Comparing the antibacterial activity of chitin nanocrystals with chitin: exploring the feasibility of chitin nanocrystals as novel pesticide nanocarriers in agriculture

Valorizing shrimp shell chitosan: a versatile biomaterial for fabricating effective antibacterial and antioxidant silver nanoparticles

Contact Info

Product

Resources

About