Antiproliferative Prenylated Xanthones from the Pericarps of Garcinia mangostana

Ying, You‐Min; Yu, Kai-Ming; Lin, Tian‐Song; Ma, Lie‐Feng; Fang, Ling; Yao, Jianbiao; Chen, Bing‐Yu; Wang, Ruwei; Shan, Wei‐Guang; Wang, Zhen; Zhan, Zha‐Jun

doi:10.1007/s10600-017-2047-7

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Anti-cancer a-mangostin is the largest constituent of xanthone in mangosteen pericarp extract, and hence it is well researched and applied in various cancer cell lines (Table 1). This include gastric (Ying et al, 2017), cervical (Muchtaridi et al, 2018), colorectal, hepatocellular, and breast (Mohamed et al, 2017) cancer. Furthermore, a-mangostin at a concentration of 30 mg/mL was able to reduce multicellular tumor spheroids derived from breast cancer cell lines (Scolamiero et al, 2018).…”

Section: Medicinal Usages Of Mangosteenmentioning

confidence: 99%

“…Both invasion and migration properties of the cancer cells were also significantly suppressed when treated with the compound, suggesting its potential use for anti-cancer drug (Xu et al, 2017). Furthermore, garcinone E also showed potential anti-cancer activity against cervical, hepatoma, gastric (Ying et al, 2017), breast, colorectal, and hepatocellular (Mohamed et al, 2017) cancer cell lines. Meanwhile, gartanin was demonstrated to inhibit HeLa cervical cancer cell lines (Muchtaridi et al, 2018) and suppressed primary brain tumor cells, glioma (Luo et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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Section: Medicinal Usages Of Mangosteenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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“…Xanthones such as mangostins and their derivatives are major compounds isolated from mangosteen, which is a fruit widely used in folk medicine in tropical countries. In addition, these compounds exhibit anti-diabetic 10 , 11 , anti-cancerous 12 , anti-bacterial 13 , anti-malarial 14 , and anti-viral 15 biological activities and inhibit NS2B-NS3, a dengue envelope virus protease 16 . Although molecular docking studies have recently shown that mangostins may exhibit anti-viral activity against the SARS-CoV-2 M pro active site, no in vitro or in vivo studies have been conducted to date using these compounds.…”

Section: Introductionmentioning

confidence: 99%

Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMO

Hengphasatporn

Harada

Wilasluck

et al. 2022

Sci Rep

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Parallel cascade selection molecular dynamics-based ligand binding-path sampling (LB-PaCS-MD) was combined with fragment molecular orbital (FMO) calculations to reveal the ligand path from an aqueous solution to the SARS-CoV-2 main protease (Mpro) active site and to customise a ligand-binding pocket suitable for delivering a potent inhibitor. Rubraxanthone exhibited mixed-inhibition antiviral activity against SARS-CoV-2 Mpro, relatively low cytotoxicity, and high cellular inhibition. However, the atomic inhibition mechanism remains ambiguous. LB-PaCS-MD/FMO is a hybrid ligand-binding evaluation method elucidating how rubraxanthone interacts with SARS-CoV-2 Mpro. In the first step, LB-PaCS-MD, which is regarded as a flexible docking, efficiently samples a set of ligand-binding pathways. After that, a reasonable docking pose of LB-PaCS-MD is evaluated by the FMO calculation to elucidate a set of protein–ligand interactions, enabling one to know the binding affinity of a specified ligand with respect to a target protein. A possible conformation was proposed for rubraxanthone binding to the SARS-CoV-2 Mpro active site, and allosteric inhibition was elucidated by combining blind docking with k-means clustering. The interaction profile, key binding residues, and considerable interaction were elucidated for rubraxanthone binding to both Mpro sites. Integrated LB-PaCS-MD/FMO provided a more reasonable complex structure for ligand binding at the SARS-CoV-2 Mpro active site, which is vital for discovering and designing antiviral drugs.

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“…Both invasion and migration properties of the cancer cells were also significantly suppressed when treated with the compound, suggesting its potential use for anti-cancer drug (Xu et al 2017). Furthermore, garcinone E also showed potential anti-cancer activity against cervical, hepatoma, gastric (Ying et al 2017), breast, colorectal and hepatocellular (Mohamed et al 2017) cancer cell lines. Meanwhile, gartanin was demonstrated to inhibit HeLa cervical cancer cell lines (Muchtaridi et al 2018) and suppressed primary brain tumor cells, glioma (Luo et al 2017) Manuscript to be reviewed induced anti-migration effect via mitogen-activated protein kinases (MAPK) signalling pathway (Luo et al 2017).…”

Section: Medicinal Usages Of Mangosteenmentioning

confidence: 90%

“…In this review, medicinal benefits of mangosteen are categorized into several distinct areas including anti-cancer, anti-microbes and anti-diabetes (Tables 1 and 2) Manuscript to be reviewed Anti-cancer α-mangostin is the largest constituent of xanthone in mangosteen pericarp extract, and hence it is well researched and applied in various cancer cell lines (Table 1). This include gastric (Ying et al 2017), cervical (Muchtaridi et al 2018), colorectal, hepatocellular and breast (Mohamed et al 2017) cancer. Furthermore, α-mangostin at a concentration of 30 µg/ml was able to reduce multicellular tumour spheroids derived from breast cancer cell lines (Scolamiero et al 2018).…”

Section: Medicinal Usages Of Mangosteenmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

View full text Add to dashboard Cite

Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

show abstract

Antiproliferative Prenylated Xanthones from the Pericarps of Garcinia mangostana

Cited by 11 publications

References 11 publications

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMO

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

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