Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis

Abstract

ABSTRACT-The antiproteinuric effect of biphenyl-4-yl)methyl]-4,5,6,7-tetrahydrocycloheptimidazole), an angiotensin II type 1 receptor antagonist, was compared with that of enalapril, an angiotensin II-converting enzyme inhibitor, using an experimental model of membranous nephropathy. KD3-671 (3, 10 and 30 mg/ kg per day) and enalapril (30 mg/kg per day) were given p.o. for 40 days, respectively. KD3-671 (30 mg /kg per day) inhibited the elevation of proteinuria and plasma total cholesterol. On the other hand, enalapril showed only a tendency to diminish these parameters. KD3-671 had an antiproteinuric effect in rats with accelerated passive Heymann nephritis. These findings provide considerable encouragement for the clinical development of KD3-671.

Protective Effect of Prostaglandin EP4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis

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