Antiprotozoal activities of compounds isolated from croton lobatus l.

Lagnika, Latifou; Weniger, Bernard; Vonthron-Senecheaub, C.; Sanni, Ambaliou

doi:10.4314/ajid.v3i1.55070

Cited by 12 publications

(21 citation statements)

References 26 publications

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“…Similarly, caffeic acid, which inhibited L. donovani and T. brucei at <10 ppm24, had no effect on C. bombi strains at concentrations up to 250 ppm. Furthermore, the EC50 for chlorogenic acid against C. bombi was >2500 ppm, which was 100 times higher than the EC50 for L. donovani (EC50 7–17 ppm4950) and T. brucei (18.9 ppm49). Although some variation in EC50 estimates could reflect methodological differences between our study and previous investigations, a difference of such magnitude for multiple phytochemicals provides strong evidence of comparatively high phytochemical resistance in C. bombi .…”

Section: Discussionmentioning

confidence: 77%

Bumble bee parasite strains vary in resistance to phytochemicals

Palmer‐Young¹,

Sadd

Stevenson

et al. 2016

Sci Rep

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Nectar and pollen contain diverse phytochemicals that can reduce disease in pollinators. However, prior studies showed variable effects of nectar chemicals on infection, which could reflect variable phytochemical resistance among parasite strains. Inter-strain variation in resistance could influence evolutionary interactions between plants, pollinators, and pollinator disease, but testing direct effects of phytochemicals on parasites requires elimination of variation between bees. Using cell cultures of the bumble bee parasite Crithidia bombi, we determined (1) growth-inhibiting effects of nine floral phytochemicals and (2) variation in phytochemical resistance among four parasite strains. C. bombi growth was unaffected by naturally occurring concentrations of the known antitrypanosomal phenolics gallic acid, caffeic acid, and chlorogenic acid. However, C. bombi growth was inhibited by anabasine, eugenol, and thymol. Strains varied >3-fold in phytochemical resistance, suggesting that selection for phytochemical resistance could drive parasite evolution. Inhibitory concentrations of thymol (4.53–22.2 ppm) were similar to concentrations in Thymus vulgaris nectar (mean 5.2 ppm). Exposure of C. bombi to naturally occurring levels of phytochemicals—either within bees or during parasite transmission via flowers—could influence infection in nature. Flowers that produce antiparasitic phytochemicals, including thymol, could potentially reduce infection in Bombus populations, thereby counteracting a possible contributor to pollinator decline.

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Section: Discussionmentioning

confidence: 77%

Bumble bee parasite strains vary in resistance to phytochemicals

Palmer‐Young¹,

Sadd

Stevenson

et al. 2016

Sci Rep

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“…Till now, significant progress has been made in investigating the different biological effects of apigenin such as anti‐inflammatory, antioxidant, anticancer, and antiprotozoal effects (Lagnika et al, ; Patel, Shukla, & Gupta, ; Shukla & Gupta, ; Tasdemir et al, ). Previous studies reported on the potential antileishmanial and in vitro antiplasmodial activities of apigenin (Fonseca‐Silva et al, ; Kohler et al, ; Lagnika et al, ; Tasdemir et al, ). This prompted us to evaluate the in vivo antiplasmodial property of apigenin against P. berghei infected mice and, thereby, to attempt to gain deeper insights into the cytotoxic potentials of this compound in human Huh7 cells and A. salina larva and also the in vivo toxicity in mice by metabolomics approach at the molecular level.…”

Section: Discussionmentioning

confidence: 99%

“…Extracted apigenin from the leaves of Caleatenuifolia exhibited the strongest antiplasmodial activity against a chloroquine‐sensitive (poW) and a chloroquine‐resistant strain (Dd2) of Plasmodium falciparum with IC 50 values of 14.6 and 25 μg/ml, respectively (Kohler et al, ). In another study, two apigenin derivative compounds, namely, vitexin and isovitexin exhibited in vitro antiplasmodial activity against chloroquine‐resistant strain (K1) with IC 50 values of 4.4 and >10 μM, respectively (Lagnika, Weniger, Senecheau, & Sanni, ). Apigenin can induce ABCC1‐mediated efflux of glutathione from mature erythrocytes and inhibit the proliferation of P. falciparum (Fallatah & Georges, ).…”

Section: Introductionmentioning

confidence: 99%

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Amiri

Nourian

Khoshkam

et al. 2018

Phytotherapy Research

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Due to the challenges in the control, prevention, and eradication of parasitic diseases like malaria, there is an urgent need to discover new therapeutic agents. Plant-derived medicines may open new ways in the field of antiplasmodial therapy. This study is aimed to investigate the toxicity and in vivo antiplasmodial activity of apigenin, a dietary flavonoid. Apigenin cytotoxicity was investigated on Huh7 cell line, brine shrimp (Artemia salina) larva, and human red blood cells. In vivo toxicity of apigenin was assessed by metabolomics approaches. Apigenin exhibited significant suppression of parasitemia in a dose-dependent manner; it suppressed Plasmodium berghei growth by 69.74%, 50.3%, and 49.23% at concentrations of 70, 35, and 15 mg/kg/day, respectively. The IC value for apigenin after 24 hr exposure to Huh7 cells was 225 μg/ml. Apigenin did not show noticeable toxicity on A. salina and also on the membrane integrity of red blood cells. After 24 hr exposure of mice to apigenin, alterations were seen in the metabolism of glucocorticoids and mineralocorticoids, bile acid metabolism (alternative pathway), sulfur metabolism, bile acid metabolism, metabolism of estrogens and androgens, cholesterol catabolism, and biosynthesis of cholesterol. These findings indicate that apigenin has potential in vivo antiplasmodial activity against P. berghei infected mice with high selectivity against malaria, but it can disrupt some metabolic pathways in mice.

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“…Soh and co-workers [15] reported that ellagic acid has shown anti-malarial activity against five different P. falciparum strains. Antimalarial activity against chloroquine (CQ) resistant P. falciparum (K1) strain was also shown by chlorogenic acid [16] . Embelin isolated from Embelia ribes Burm.…”

Section: Resultsmentioning

confidence: 99%

Natural Compounds as Inhibitors of Plasmodium Falciparum Enoyl-acyl Carrier Protein Reductase (PfENR): An In silico Study

Narayanaswamy¹,

Lam²,

Ismail³

2017

Journal of the Chosun Natural Science

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Demand for a new anti-malarial drug has been dramatically increasing in the recent years. Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) plays a vital role in fatty acid elongation process, which now emerged as a new important target for the development of anti-microbial and anti-parasitic molecules. In the present study, 19 compounds namely alginic acid, atropine, chlorogenic acid, chrotacumine A & B, coenzyme Q 1 , 4-coumaric acid, curcumin, ellagic acid, embelin, 5-O-methyl embelin, eugenyl glucoside, glabridin, hyoscyamine, nordihydroguaiaretic acid, rohitukine, scopolamine, tlatlancuayin and ursolic acid were evaluated on their docking behaviour on P. falciparum enoyl-acyl carrier protein reductase (PfENR) using Auto dock 4.2. The docking studies and binding free energy calculations exhibited that glabridin gave the highest binding energy (-8.07 kcal/mol) and 4-coumaric acid in contrast showed the least binding energy (-4.83 kcal/mol). All ligands except alginic acid, ellagic acid, hyoscyamine and glabridin interacted with Gln409 amino acid residue. Interestingly four ligands namely coenzyme Q 1 , 4-coumaric acid, embelin and 5-O-methyl embelin interacted with Gln409 amino acid residue present in both chains (A & B) of PfENR protein. Thus, the results of this present study exhibited the potential of these 19 ligands as P. falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitory agents and also as anti-malarial agents.

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Antiprotozoal activities of compounds isolated from croton lobatus l.

Cited by 12 publications

References 26 publications

Bumble bee parasite strains vary in resistance to phytochemicals

Bumble bee parasite strains vary in resistance to phytochemicals

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Natural Compounds as Inhibitors of Plasmodium Falciparum Enoyl-acyl Carrier Protein Reductase (PfENR): An In silico Study

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