Antiprotozoal Activity of Extracts of Elaeodendron Trichotomum (Celastraceae)

Roca-Mézquita, Carolina; Graniel-Sabido, Manlio; Moo-Puc, Rosa; León-Deniz, Lorena V.; Gamboa-León, Rubí; Arjona-Ruiz, Carely; Tun‐Garrido, Juan; Mirón-López, Gumersindo

doi:10.21010/ajtcam.v13i4.21

Cited by 9 publications

(6 citation statements)

References 19 publications

(14 reference statements)

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“…Moreover, a simple HPLC method was developed for the identification and comparison of quinonemethide triterpenes in wild Hippocratea excelsa and “cancerina”, a method useful for the control of this herb used in Mexican traditional medicine as an alternative cancer treatment [41]. In addition, Roca-Mézquita and co-workers performed quantitative analysis of pristimerin and tingenone in a dichloromethane extract of Elaeodendron trichotomum , revealing that this species contains both celastroloids, although, unexpectedly, pristimerin was present in very low concentration [29].…”

Section: Resultsmentioning

confidence: 99%

“…Pristimerin has been reported to have promising clinical potential as both a therapeutic and chemopreventive agent for various types of cancer, including breast [18], glioma [19], prostate [20], pancreatic [21], ovarian [22], colon [23], esophageal squamous [24], osteosarcoma [25], and uveal [26] cancer, via a number of mechanisms [27]. Moreover, tingenone displays antinociceptive [28] and antiprotozoal [29] activities. Since there is pharmacological interest in this type of metabolite and their synthesis is not commercially viable, some research groups have investigated in vitro plant systems to increase their production [30].…”

Section: Introductionmentioning

confidence: 99%

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Development and Validation of an HPLC-PDA Method for Biologically Active Quinonemethide Triterpenoids Isolated from Maytenus chiapensis

et al. 2019

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Background: Quinonemethide triterpenoids, known as celastroloids, constitute a relatively small group of biologically active compounds restricted to the Celastraceae family and, therefore, they are chemotaxonomic markers for this family. Among this particular type of metabolite, pristimerin and tingenone are considered traditional medicines in Latin America. The aim of this study was the isolation of the most abundant celastroloids from the root bark of Maytenus chiapensis, and thereafter, to develop an analytical method to identify pristimerin and tingenone in the Celastraceae species. Methods: Pristimerin and tingenone were isolated from the n-hexane-Et2O extract of the root bark of M. chiapensis through chromatographic techniques, and were used as internal standards. Application of a validated RP HPLC-PDA method was developed for the simultaneous quantification of these two metabolites in three different extracts, n-hexane-Et2O, methanol, and water, to determine the best extractor solvent. Results: Concentration values showed great variation between the solvents used for extraction, with the n-hexane–Et2O extract being the richest in pristimerin and tingenone. Conclusions: M. chiapensis is a source of two biologically active quinonemethide triterpenoids. An analytical method was developed for the qualification and quantification of these two celastroloids in the root bark extracts of M. chiapensis. The validated method reported herein could be extended and be useful in analyzing Celastraceae species and real commercial samples.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Validation of an HPLC-PDA Method for Biologically Active Quinonemethide Triterpenoids Isolated from Maytenus chiapensis

et al. 2019

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“…In this condition the following species are employed for this purpose: Cheiloclinium cognatum, Tontelea micranta, Couepia bracteosa and Parinari montana. Cheiloclinium cognatum has been shown to have compounds such as tingenone and tingenol with activity against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis and Trypanosoma cruzi (ROCA-MÉZQUITA et al, 2016), which could substantiate the effectiveness of its use in diarrhea, especially those caused by worms. However, on suspicion of worms, the treatment suggested by the indigenous savant in Cacoal community is made with macerated Erythroxylum macrophyllum and Discoplhora Miers.…”

Section: Discussionmentioning

confidence: 96%

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Meneguelli

Camargo²,

Buccini

et al. 2020

Inter

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Plants have been widely used to treat many diseases, especially by traditional communities as Indians, that can be considered as an important source of empirical knowledge about the medicinal potential of the Brazilian biodiversity. This study aimed to investigate the use of medicinal plants by a particular Amazon-Indian community named Ikólóéhj (Gavião). The data was obtained based on a semi-structured interview and long-term visits along the indigenous area to harvest the botanical material to subsequent identification and storage in herbarium. In the present work, we identify 23 plant species and three morphospecies, distributed into Ferns / Lycophytes and Angiosperms. In addition, we show that leaves (78%), bark (13%) and roots (9%) were used via maceration (49%), topical use (26%), infusion and bath (13%), and decoction (9%). These plants were used to treat pain, diarrhea, malnutrition, parasites infection, wounds, and snakebites. We also observe that the knowledge about medicinal plants is shared to the older members of the community and this information is transmitted orally to the next generations. Thus, the present study contributes to the regrowth and preservation of knowledge about the use of medicinal plants providing important subsidies for understanding of therapeutic properties of Amazonian plants.

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“…Elaeodendron trichotomum (Turcz.) Lundell is a plant found in the south and southeast of Mexico, and Central America, where it grows on sand dunes, mangrove edges, and semi-deciduous medium woodland [26]. The species is a big, branching, small evergreen tree that may grow up to 12 feet tall.…”

Section: Traditional Usesmentioning

confidence: 99%

Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review

et al. 2022

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Elaeodendron is a genus of tiny trees, shrubs, vines, and herbs consisting of about 23 species. It is used in traditional medicine and has a wide range of pharmacological activities. From the plants in this genus, flavonoids, terpenoids, cardiac glycosides, and cardenolides have been isolated. Elaeodendron species have been the subject of numerous in vitro investigations; however, not many vivo studies are available. Preclinical investigations have also revealed antiviral, anti-HIV, anticancer, antiproliferative, antioxidant, antifungal, anti-inflammation, cytotoxic, anti-plasmodial, anti-arthritic, antibacterial, and anti-diabetic activities. Bioactive substances found in Elaedendron that function in a variety of ways are related to these biological processes. Several databases, including PubMed, Scopus, etc., were searched using keywords such as “Elaeodendron”, “chemical constituents”, “anti-cancer”, “anti-viral”, “pharmacology”, etc., to perform a comprehensive review of the current literature. In this sense, this review intends to provide the most recent developments in the ethnomedical use of Elaeodendron species, and their therapeutic benefits and bioactive compounds. Many species of this genus are reported to be toxic. To provide stronger scientific support for their conventional usage, more in vivo and clinical research for mechanism-based pharmacological evaluation as well as toxicological studies should be carried out in the future.

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Antiprotozoal Activity of Extracts of Elaeodendron Trichotomum (Celastraceae)

Cited by 9 publications

References 19 publications

Development and Validation of an HPLC-PDA Method for Biologically Active Quinonemethide Triterpenoids Isolated from Maytenus chiapensis

Development and Validation of an HPLC-PDA Method for Biologically Active Quinonemethide Triterpenoids Isolated from Maytenus chiapensis

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review

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