Antiprotozoal Activity Of Some Egyptian Plants

Zaki, AA; Ali, Zulfaqar; El-Amier, YA; Ashour, Ahmed; Oluwasesan, BM; Jain, S. K.; Tekwani, Babu L.; Khan, IA

doi:10.1055/s-0036-1578787

Cited by 3 publications

(3 citation statements)

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“…Also, the hydroethanolic extract of the plant inhibited L. major and L. infantum parasites with IC 50 = 33.64 ± 0.46 µg/mL and 143.4 ± 0.28 µg/mL, respectively. 2 An in vitro antiprotozoal activity of crude methanol extract of Pallenis hierochuntica (Asteriscus hierochuntica) was reported by Zaki et al, 31 in which the extract showed promising and good antitrypanosomal activity against the promastigotes of T. brucei with IC 50 and IC 90 values being 1.18 and 1.89 µg/mL, respectively. Our study is the first report of the antileishmanial and antitrypanosomal activity of the fractions of Pallenis hierochuntica.…”

Section: In Vitro Antiparasitic Screening Of Fractions and Isolated C...mentioning

confidence: 92%

In vitro Assessment of Antiprotozoal and Antimicrobial Activities of Fractions and Isolated Compounds from Pallenis hierochuntica

Imieje¹,

Falodun

Zaki

2022

ACSi

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The antiprotozoal and antimicrobial properties of the extract and fractions of the whole plant of Pallenis hierochuntica were investigated against a panel of pathogenic organisms. Fractionation of the methanol extract of the whole plant of P. hierochuntica using reverse-phase chromatography gave 28 fractions and led to the isolation of 2 new bisabolone hydroperoxides, 6,10β,11-trihydroxybisabol-2-ene-1-one (1a), 6,10α,11-trihydroxybisabol-2-ene-1-one (1b) and also 6,10β-dihydroxybisabol-2,11-diene-1-one (2). They were characterised by extensive spectrometric analysis. Anti-infective investigations of the fractions revealed that fractions 22 to 26 possessed significant antimalarial activity against the D6 and W2 strains of Plasmodium falciparum with IC50 = 7.62–9.91 μg/mL and 5.49–6.08 μg/mL, respectively, and SI > 6.0 on average. Fractions 7, 16 to 24 exhibited good activity against Leishmania donovani promastigotes (IC50 = 6.71–18.77 μg/mL). Fractions 25 to 28 were active against Trypanosoma brucei trypomastigotes, fraction 25 being the most potent (IC50 = 4.13 μg/mL). Only fractions 11 to 13 were active against Aspergillus fumigatus (IC50 = 13.406 μg/mL). Compounds 1a and 2 were not promising against the organisms tested. 1a and 1b were characterised for the first time.

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Section: In Vitro Antiparasitic Screening Of Fractions and Isolated C...mentioning

confidence: 92%

In vitro Assessment of Antiprotozoal and Antimicrobial Activities of Fractions and Isolated Compounds from Pallenis hierochuntica

Imieje¹,

Falodun

Zaki

2022

ACSi

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“…Certain different desert plants have been shown to have strong antibacterial and antifungal activity. Studies of the wormwood plant have shown evidence of its strong antibacterial activity and antifungal activity against some yeast (Zaki et al, 1984, Kaul et al, 1976.…”

Section: Reasons Behind Camel Urine Benefitsmentioning

confidence: 99%

A Review of the Therapeutic Characteristics of Camel Urine

Alkhamees¹,

Alsanad²

2017

Afr J Tradit Complement Altern Med

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Background: The therapeutic use of camel urine has been known for centuries, with evidence of its use for medicinal purposes found in early folklore. It has been used to cure different diseases; however, the significant therapeutic benefits of urine have yet to undergo rigorous scientific evaluation. In this review, a summary of the scientific evidence that supports these therapeutic actions has been presented. Materials and methods: A literature search of different electronic databases including PubMed, Medline, SCOPUS, Web of Knowledge, and Google Scholar were conducted to identify published studies exploring the therapeutic effects of camel urine. 'Camel' and 'Urine', 'Medicinal properties', 'Natural products' were entered into the databases as key words. Reference lists of published reviews retrieved by the search were also searched to identify relevant papers. Result: There have been several laboratory and limited clinical studies providing evidence of the therapeutic effects of camel urine in the treatment of cancer, viral hepatitis and other viral, bacterial and parasitic infections. Therapeutic uses in the cardiovascular system have also been discovered, with regard to platelet and fibrinolytic actions. Conclusion:The exploration of the use of camel urine is of great interest to determine the efficacy of this practice, as well as the safety of the patients being treated. This review presented the benefits of camel urine, which were commonly drawn from small laboratory studies. Therefore, many more preclinical and clinical studies are needed to examine the efficacy and safety of the use of camel urine in in the treatment of disease.

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“…Examples of chemicals found in Calligonum plants include anthraquinones, flanovonids, and dehydrodicatechin (Farid et al, 2007;Ghazanfar 1994;Kamil et al, 2000). Anthraquinones found in Calligonum showed high antimicrobial potential (Alkhalifah, 2013;Zaki et al 1984). Similarly, these plants might have some components that have potential to control certain oilborne plant pathogens.…”

Section: Introductionmentioning

confidence: 99%

Effect of biofumigation by Calligonum polygonoides, dry olive leaves, and ash of olive leaves on chilli pepper growth and recovery of Rhizoctonia solani

Al-Hammouri

Al-Kofahi²,

Ibbini³

et al. 2018

AAS

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Rhizoctonia solani J.G. Kühn is a serious soilborne pathogen in chilli fields worldwide. This study examined the effect of biofumigation using arta (Calligonum polygonoides L.) and olive (Olea europaea L.) plant material on chilli growth and recovery of R. solani from chilli plants. The Gliva Rhizoctonia solani J.G. Kühn je pomembne talni pathogen na poljih čilijev širom po svetu. V raziskavi je bil preučen učinek biofumigacije z vrsto dresnovk (Calligonum polygonoides L.) in pripravki iz oljke (Olea europaea L.) na rast čilijev in njihovega uspevanja po inokulaciji z glivo R. solani . Poskus je bil izveden v rastlinjaku kot lončni poskus, v katerem prsti niso dodali ničesar (kontrola) ali z dodatkom rastlinskih delov vrst Calligonum in Olea (oljčni listi ali pepel iz njih). Čiliji so bili posajeni v prst z dodatki in inokulirani z glivo R. solani. Zabeležena je bila višina rastlin, število plodov in frekvenca okrevanih rastlin po inokulaciji z glivo R. solani. Dodatki delov vrste Calligonum k prsti so rezultirali k najmanjši obnovi glive R. solani. Še več, dodatki delov te vrste so povečali višino in suho maso čilijev v primerjavi z drugimi obravnavanji. Tudi obravnavanja s pripravki iz oljke so zavrla rast glive R. solani in pospešila rast čilijev v primerjavi s kontrolo. Pripravki iz vrste C. polygonoides in oljke so lahko biofumigacijska sredstva za nadzor talne glive R. solani.

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Antiprotozoal Activity Of Some Egyptian Plants

Cited by 3 publications

References 0 publications

In vitro Assessment of Antiprotozoal and Antimicrobial Activities of Fractions and Isolated Compounds from Pallenis hierochuntica

In vitro Assessment of Antiprotozoal and Antimicrobial Activities of Fractions and Isolated Compounds from Pallenis hierochuntica

A Review of the Therapeutic Characteristics of Camel Urine

Effect of biofumigation by Calligonum polygonoides, dry olive leaves, and ash of olive leaves on chilli pepper growth and recovery of Rhizoctonia solani

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