Antiprotozoal and Anthelmintic Activity of Zinc Oxide Nanoparticles

Neto, José Rodrigues do Carmo; Guerra, Rhanoica Oliveira; Machado, Juliana Reis; Silva, Anielle Christine Almeida; Silva, Marcos

doi:10.2174/0929867328666210709105850

Cited by 8 publications

(2 citation statements)

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“…Different metal oxide NPs have been investigated for determination of their potential against various parasites and researchers have obtained good findings (do Carmo Neto et al 2022 ; Franco et al 2016 ). In a recent study by Faisal et al ( 2021 ), CuO, NiO, and Cu/Ni hybrid NPs were greenly obtained by using Curcuma longa roots extract.…”

Section: Other Biomedical Applications Of Cuo Npsmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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Versatile nature of copper oxide nanoparticles (CuO NPs) has made them an imperative nanomaterial being employed in nanomedicine. Various physical, chemical, and biological methodologies are in use for the preparation of CuO NPs. The physicochemical and biological properties of CuO NPs are primarily affected by their method of fabrication; therefore, selectivity of a synthetic technique is immensely important that makes these NPs appropriate for a specific biomedical application. The deliberate use of CuO NPs in biomedicine questions their biocompatible nature. For this reason, the present review has been designed to focus on the approaches employed for the synthesis of CuO NPs; their biomedical applications highlighting antimicrobial, anticancer, and antioxidant studies; and most importantly, the in vitro and in vivo toxicity associated with these NPs. This comprehensive overview of CuO NPs is unique and novel as it emphasizes on biomedical applications of CuO NPs along with its toxicological assessments which would be useful in providing core knowledge to researchers working in these domains for planning and conducting futuristic studies. Key Points • The recent methods for fabrication of CuO nanoparticles have been discussed with emphasis on green synthesis methods for different biomedical approaches. • Antibacterial, antioxidant, anticancer, antiparasitic, antidiabetic, and antiviral properties of CuO nanoparticles have been explained. • In vitro and in vivo toxicological studies of CuO nanoparticles exploited along with their respective mechanisms. Graphical Abstract

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Section: Other Biomedical Applications Of Cuo Npsmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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“…Metal oxide NPs, such as ZnO, induce the production of reactive oxygen species [ 5 ], which are important for anthelmintic and antiprotozoal activities, as seen in example [ 6 ]. In an attempt to potentiate the varied actions of ZnO NPs, studies have associated these NPs with silver (Ag) or silver oxide (AgO) NPs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity Assessment of New Ag-ZnO/AgO Nanocomposites: An In Vitro and In Vivo Approach

do Carmo Neto,

Franco,

Braga

et al. 2024

JFB

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Zinc oxide nanoparticles (ZnO NPs) are metal oxide nanomaterials, which are important for several applications: antibacterial, anthelmintic, antiprotozoal and antitumoral, among others. These applications are mainly related to the ability to spontaneously produce and induce the production of reactive oxygen species that are important components for the destruction of pathogens and tumor cells. While trying to potentiate ZnO NPs, studies have associated these NPs with silver oxide (AgO) or silver (Ag) NPs. It has already been reported that this combination (Ag-ZnO/AgO NPs) is able to enhance the microbicidal potential. Although possessing much potential for several purposes, it is important to evaluate whether this association also poses the risk of toxicity to cells and experimental models. Therefore, this work aimed to evaluate the toxicity of various Ag-ZnO/AgO NP nanocomposites, in vitro and in vivo. Accordingly, ZnO nanocrystals and nanocomposites with various concentrations of AgO (ZnO:5Ag, ZnO:9Ag or ZnO:11Ag) were used in different cytotoxicity models: Galleria mellonella (G. mellonella), cell lines (VERO and RAW 264.7) and C57BL/6 mice. In the G. mellonella model, four concentrations were used in a single dose, with subsequent evaluation of mortality. In the case of cells, serial concentrations starting at 125 µg/mL were used, with subsequent cytotoxicity assessment. Based on the safe doses obtained in G. mellonella and cell models, the best doses were used in mice, with subsequent evaluations of weight, biochemistry as also renal and liver histopathology. It was observed that the toxicity, although low, of the nanocomposites was dependent upon the concentration of AgO used in association with ZnO NPs, both in vitro and in vivo.

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