Antiprotozoal Properties of 16,17-Dihydroxybrachycalyxolide from<i>Vernonia brachycalyx</i>

Oketch-Rabah, Hellen A.; Christensen, S. Brøgger; Frydenvang, Karla; Dossaji, S. F.; Theander, Thor G.; Cornett, Claus; Watkins, William M.; Kharazmi, Arsalan; Lemmich, Else

doi:10.1055/s-2006-957514

Cited by 44 publications

(29 citation statements)

References 7 publications

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“…(Gu et al, 1988) and Hypericum calcyinum L. (Decosterd et al, 1991) have shown in vivo and in vitro activity Kirkia wilmsii 3.7 No previous reports of antiplasmodial activity Lippia javanica 3.8 Reported to be a mosquito repellent (Govere et al, 2000), but no previous reports of antiplasmodial activity Ocimum americanum a 4.2 Used as a mosquito repellent (Seyoum et al, 2002) (Alves et al, 1997;Oketch-Rabah et al, 1998;Abosi and Raseroka, 2003;Kraft et al, 2003) …”

Section: Resultsmentioning

confidence: 99%

“…3.0 Several Vernonia species have shown activity in vitro and in vivo (Alves et al, 1997;Oketch-Rabah et al, 1998;Abosi and Raseroka, 2003;Kraft et al, 2003) Vernonia oligocephala 3.5 Several Vernonia species have shown activity in vitro and in vivo (Alves et al, 1997;Oketch-Rabah et al, 1998;Abosi and Raseroka, 2003;Kraft et al, 2003) a Naturalised in South Africa.…”

Section: Vernonia Myrianthamentioning

confidence: 99%

“…Croton (Euphorbiaceae) (Prozesky et al, 2001), Acacia (Fabaceae) (El Tahir et al, 1999b), Hypericum (Clusiaceae) (Decosterd et al, 1991;Gu et al, 1988), Triumfetta (Tiliaceae) (Muñoz et al, 2000) and Vernonia (Asteraceae) (Abosi and Raseroka, 2003;Kraft et al, 2003;Oketch-Rabah et al, 1998;Alves et al, 1997)) have previously been shown to have antiplasmodial activity. In addition to identifying further species within these genera that display activity, our findings are substantiated by earlier reported antiplasmodial activity elsewhere in the genera.…”

Section: Vernonia Myrianthamentioning

confidence: 99%

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In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

CLARKSON¹

2004

Journal of Ethnopharmacology

107

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The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse antimalarial agents. The present study reports on the in vitro antiplasmodial activity of 134 plant taxa native to or naturalised in South Africa, representing 54 families, which were selected semi-quantitatively using weighted criteria. The plant extracts were tested for in vitro activity against a Plasmodium falciparum strain D10 using the parasite lactate dehydrogenase (pLDH) assay. Of the 134 species assayed, 49% showed promising antiplasmodial activity (IC 50 ≤ 10 g/ml), while 17% were found to be highly active (IC 50 ≤ 5 g/ml). Several plant species and genera were shown for the first time to possess in vitro antiplasmodial activity. These results support a rational rather than random approach to the selection of antiplasmodial screening candidates, and identify a number of promising taxa for further investigation as plant-based antimalarial agents.

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Section: Resultsmentioning

confidence: 99%

Section: Vernonia Myrianthamentioning

confidence: 99%

Section: Vernonia Myrianthamentioning

confidence: 99%

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In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

CLARKSON¹

2004

Journal of Ethnopharmacology

107

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“…También se han identificado quinonas y triterpenos reportados con actividad antimicrobiana (Muñoz-Jáuregui, Ramos-Escudero, AlvaradoOrtiz, & Castañeda-Castañeda, 2007;Ramírez, Mendoza, Arreola, & Ordaz, 2010), así como también en el presente estudio, identificamos la presencia de sesquiterpenlactonas, las cuales se han reportado con actividad contra los parási-tos de la malaria y la leishmaniasis en ensayos in vitro (Oketch-Rabah et al, 1998;Sülsen, 2012;Cano de Terrones, 2014;Galarraga, Luis, Rojas, Offer, & Dobois, 2014).…”

Section: Discussionunclassified

Actividad contra Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) de extractos metanólicos de plantas de uso medicinal en México

Pérez-Treviño

Galaviz

Iracheta-Villarreal

et al. 2017

RBT

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Activity against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) of methanolic extracts of medicinal use plants in Mexico. American trypanosomiasis is a potentially lethal disease caused by the hemoflagellate protozoan Trypanosoma cruzi. This neglected disease affects from 6 to 7 million people worldwide. Currently there are only two medicines to treat this disease: beznidazol and nifurtimox, both effective if they are administrated in the acute phase of infection, although their effectiveness fades away in the chronic phase; it also induces significant side effects. The aim of this study is to screen the trypanocidal activity of methanolic extracts from Hematoxilum brasiletto, Marrubium vulgare, Schinus molle, and Cympongon citratus, against T. cruzi epimastigotes, followed by the chromatographic separation, and identification of active compounds of the best candidate by colored chemical reactions; furthermore, it was also determined their cytotoxic effect in human lymphocytes and the brine shrimp Artemia salina. The extract of H. brasiletto showed the highest anti-T. cruzi activity with a inhibitory concentration (IC 50 ) of 543 µg/mL; in descending order, it was followed by M. vulgare (IC 50 = 647 µg/mL), S. molle (IC = 827 µg/mL) and finally, C. citratus (IC = 1 210 µg/mL). The chromatographic fraction Fr22 from H. brasiletto showed the best anti-T. cruzi effectivity (IC 50 = 0.238 mg/mL), when compared to the other fraction or the whole extract, with no cytotoxic effect against human lymphocytes or A. salina. The active compounds were identified as tannins, quinones, flavonoids and sesquiterpenlactones. In conclusion, active compounds against T. cruzi were identified for the first time in H. brasiletto, with non-cytotoxic effects. The H. brasiletto extract, according to our results, could be used as an alternative treatment for the Chagas disease; however, additional studies will be necessary to test their activity and doses in a murine model, with the complete identification of the active compounds, on which we are investigating. Rev. Biol. Trop. 65 (4) La tripanosomiasis americana es una enfermedad potencialmente mortal causada por el protozoario Trypanosoma cruzi (Chagas, 1909). Las zonas endémicas abarcan 21 países de América Latina, donde el parásito se transmite principalmente por vía vectorial (Calvo, 2015). La enfermedad presenta dos fases; el inicio de la infección es la fase aguda, y permanece hasta dos meses con parasitemia, fiebre y malestar. La etapa crónica, que se desarrolla después de algunos años en el 25-35 % de las personas infectadas, se caracteriza por no presentar parasitemia; en esta fase, los parásitos se alojan y reproducen en nidos de amastigotes de órganos y sistema nervioso periférico, de los cuales un 30 % desarrolla desórdenes cardíacos y un 10 %, trastornos nerviosos y digestivos como el megacolon o megaesófago (Martino, 2012). Actualmente, los movimientos migratorios la han diseminado desde las regiones endé-micas hasta Canadá y varios países europeos (Slot, Ho...

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“…[13][14][15][16] Estas duas classes de compostos, em particular as lactonas, são consideradas marcadores quimiotaxonômicos do gênero. [8][9][10][11][12]15 Inúmeras espécies de Vernonia são empregadas na medicina tradicional no tratamento de patologias diversas e como resultado, muitas têm sido investigadas do ponto de vista farmacológico, revelando importantes propriedades como antiplasmódica, [17][18][19] analgésica, antipirética e antiinflamatória, 20,21 antimicrobiana, [22][23][24] hiperglicêmica, 25 antioxidante 16 e vasodilatadora. 26 Vernonia chalybaea é uma planta de porte subarbustivo, com cerca de 1,0 m de altura e muito ramificada, freqüente na flora cearense.…”

Section: Introductionunclassified

Constituintes químicos de Vernonia chalybaea mart.

Costa¹,

Bandeira²,

Albuquerque³

et al. 2008

Quím. Nova

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Recebido em 12/10/07; aceito em 16/4/08; publicado na web em 22/9/08 CHEMICAL CONSTITUENTS OF Vernonia chalybaea MART. The chemical investigation of the hexane and ethanol extracts from aerial parts of Vernonia chalybaea conducted to the isolation and characterization of a new aliphatic tetrahydroxyl ether, along with a series of known compounds such as 4α,10α-epoxyaromadendrane, friedelin, taraxasteryl acetate, pseudotaraxasteryl acetate, lupeyl acetate, lupeol, α-amiryn, β-amiryn, β-sitosterol, stigmasterol, 2,3-dimethyl-1,2,3-tri-hydroxybuthanol, angophorol, angophorol-7-Oglucoside, angophorol-7-O-rutinoside, 3,7-dimethoxy-5,3',4'-trihydroxyflavone and acacetin. The structures of all compounds were determined by spectroscopic analysis and comparison with published spectral data.Keywords: Vernonia chalybaea; Asteraceae; chemical constituents. introduÇÃoA família Asteraceae, também denominada Compositae, compreende cerca de 1.100 gêneros, representados por aproximadamente 25.000 espécies amplamente distribuídas em todas as regiões tropicais, subtropicais e temperadas. No Brasil, é representada por aproximadamente 180 gêneros, envolvendo espécies herbáceas, arbustivas ou subarbustivas e raramente arbóreas, podendo ser anuais ou perenes. 1O gênero Vernonia (tribo Vernonieae), um dos maiores desta família, é representado por cerca de 1000 espécies concentradas nas áreas tropicais e subtropicais do mundo, especialmente na África e América do Sul.2 Estudos fitoquímicos envolvendo plantas do gênero relatam a ocorrência de classes distintas de metabólitos secundários como triterpenos, 3,4 diterpenos 5 e esteróides, 6,7 sendo, no entanto, os constituintes químicos mais freqüentes as lactonas sesquiterpênicas [8][9][10][11][12] e os flavonóides. [13][14][15][16] Estas duas classes de compostos, em particular as lactonas, são consideradas marcadores quimiotaxonômicos do gênero. [8][9][10][11][12]15 Inúmeras espécies de Vernonia são empregadas na medicina tradicional no tratamento de patologias diversas e como resultado, muitas têm sido investigadas do ponto de vista farmacológico, revelando importantes propriedades como antiplasmódica, [17][18][19] Vernonia chalybaea é uma planta de porte subarbustivo, com cerca de 1,0 m de altura e muito ramificada, freqüente na flora cearense. 27A composição química de seu óleo essencial foi previamente investigada por nosso grupo de pesquisa. 28 Neste trabalho, descreve-se pela primeira vez, a prospecção química dos extratos da parte aérea de V. chalybaea. resuLtados e disCussÃoA investigação química dos extratos hexânico e etanólico da parte aérea de V. chalybaea resultou no isolamento de terpenóides, flavonóides, alcoóis e éteres alifáticos, cujas estruturas foram determinadas por métodos espectroscópicos, especialmente RMN 1 H e 13 C, incluindo técnicas uni-e bidimensionais (COSY, HMQC, HMBC e NOESY), e no caso dos compostos conhecidos, confirmadas através da comparação de seus dados espectroscópicos e propriedades físicas com aqueles registrados na literatura. Do extrato hexânico...

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Antiprotozoal Properties of 16,17-Dihydroxybrachycalyxolide fromVernonia brachycalyx

Cited by 44 publications

References 7 publications

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Actividad contra Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) de extractos metanólicos de plantas de uso medicinal en México

Constituintes químicos de Vernonia chalybaea mart.

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