ANTIPSEUDOBASE: Database of Antimicrobial Peptides and Essential Oils Against Pseudomonas

Abstract

Pseudomonas aeruginosa is one of the most common pathogens. The antimicrobial peptides and essential oils display narrow-or broad-spectrum activity against bacteria including this strain. The assembly of such information of these molecules in one central resource such as a database would therefore be of great bene t to the exploitation of these bioactive molecules in the present context of increasing antibiotic resistance and natural bio-preservation needs. The database ANTIPSEUDOBASE is created to facilitate access to important information on antimicrobial peptides and essential oils against Pseudomonas aeruginosa. Now, the database contains calculated or predicted physicochemical properties of 560 sequences of antimicrobial peptides produced by diverse organisms, and general data of 111 essential oils. It permits a quick and easy search of peptides based on their activity as well as their general, physicochemical properties and literature data. These data are very useful to perform further bioinformatic or chemometric analysis and would certainly be useful for the development of new drugs and medical use.