1989
DOI: 10.1007/bf01963771
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Antipseudomonal therapy in cystic fibrosis: Aztreonam and amikacin versus ceftazidime and amikacin administered intravenously followed by oral ciprofloxacin

Abstract: In order to determine the optimal antipseudomonal therapy in patients with cystic fibrosis aztreonam plus amikacin was compared to ceftazidime plus amikacin, and these two-week hospital regimens were followed by oral ciprofloxacin given for four weeks. Fifty-six cases of acute pulmonary exacerbation of the disease in 42 patients associated with isolation of Pseudomonas aeruginosa from the sputum were randomly treated with either aztreonam or ceftazidime (300mg/kg/day i.v.; maximum daily dose 12g) in combinatio… Show more

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Cited by 41 publications
(23 citation statements)
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“…The recommended dosages administered at Cystic Fibrosis French Reference Centers are historically based on the following European Consensus guideline, i.e., 150 to 250 mg/kg/day divided every 6 to 8 h (maximum of 12 g/day) and on studies performed at higher intermittent or continuous regimens that have demonstrated similar tolerability profiles and improved efficacy in the management of the APE episodes (14,(25)(26)(27)(28). In contrast, it has been demonstrated that compared with an intermittent infusion dosing regimen, continuous-infusion beta-lactam therapy achieves the target serum concentration for susceptible organisms using a 41% to 50% lower total daily dose of CAZ (29,30).…”
Section: Discussionmentioning
confidence: 99%
“…The recommended dosages administered at Cystic Fibrosis French Reference Centers are historically based on the following European Consensus guideline, i.e., 150 to 250 mg/kg/day divided every 6 to 8 h (maximum of 12 g/day) and on studies performed at higher intermittent or continuous regimens that have demonstrated similar tolerability profiles and improved efficacy in the management of the APE episodes (14,(25)(26)(27)(28). In contrast, it has been demonstrated that compared with an intermittent infusion dosing regimen, continuous-infusion beta-lactam therapy achieves the target serum concentration for susceptible organisms using a 41% to 50% lower total daily dose of CAZ (29,30).…”
Section: Discussionmentioning
confidence: 99%
“…Doses used in this study were calculated asmilograms per kilogram of body-weight, base on the amounts used in human therapy. 9) Over 30 years ago, some investigators started reporting the effects of antibiotics on the immune response. 10,11) It was reported that macrolides had an immunomodulatory effect 11,12) and attenuated an increase in rat paw volume induced by injecting carregenin into the paws.…”
Section: Discussionmentioning
confidence: 99%
“…In a prospective, randomized, double blinded study comparing the efficacy and safety of ciprofloxacin versus ceftazidime/tobramycin in P. aeruginosa infected CF patients it was concluded that sequential intravenous/oral ciprofloxacin monotherapy offers a safe and efficacious alternative to standard parenteral therapy for acute pulmonary exacerbations in CF [133]. Oral ciprofloxacin therapy for 4 weeks has also been shown to prolong the beneficial effects of intravenous antibiotic therapy [134]. However, in seriously affected CF patients conventional treatment was significantly better than quinolone treatment [135].…”
Section: Oral Antipseudomonal Antibiotic Therapy In Cystic Fibrosismentioning
confidence: 99%