Antipsychotic-associated psoriatic rash – a case report

Abstract

BackgroundAntipsychotics are a heterogeneous group of drugs. Although, antipsychotics have been used for years, unexpected side effects may still occur. With this case report we focus on a possible association between psoriasis and antipsychotics.Data on the patient’s course of psychiatric disease, onset of psoriasis and its evolution were extracted from the patient’s medical files.Case presentationWe present a case of a 21-year-old female diagnosed with schizophrenia. She was initially treated with quetiapine, and later switched to aripiprazole due to weight gain. After initiation of antipsychotic treatment, the patient suffered from severe psoriasis lesions.ConclusionsAntipsychotics may possess immunological properties that may be involved in immune-mediated conditions, such as psoriatic rash. Further studies are warranted to determine causality and mechanism.

Contribution from MHC-Mediated Risk in Schizophrenia Can Reflect a More Ethnic-Specific Genetic and Comorbid Background

“…Few other studies have set out to test well-defined immunosuppressive agents in schizophrenia. Even the antipsychotic drugs such as haloperidol and clozapine are highly immunosuppressive [ 36 , 37 ]. Emerging reports indicate that antipsychotics may also be involved in immune-mediated conditions, such as psoriatic rash [ 38 ].…”

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

“…17 Among antipsychotics, olanzapine, quetiapine and aripiprazole have been shown to induce psoriasis. 18 However, druginduced psoriasis resolves after discontinuing the causative drug most of the time. Our case had repeated exacerbations associated with a manic episode even when she was off medication.…”

Use of Clozapine for Resolving Lamotrigine-Induced Skin Lesions Caused by Schizophrenia Treatment

“…Since this was a case report of an inpatient, oversight by the institutional review board was not necessary. Because the patient was lying in bed almost all day, tired and stiff, meaning that zotepine had poor efficacy and had doubts about extrapyramidal symptoms (EPS) and rash / desquamation (Bujor et al 2017). Thus zotepine was stopped and switched to clozapine.…”