Antipsychotic Drug-Induced Movement Disorders: A Forgotten Problem?

Pringsheim, Tamara; Barnes, Thomas R. E.

doi:10.1177/0706743718772526

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Akathisia may have different causes, but the most common is exposure to dopamine-blocking agents like antipsychotics. 113 First-generation neuroleptics, such as haloperidol and chlorpromazine, are associated with a higher risk to develop akathisia due to their strong D2-blocking effect, whereas second-generation agents are less likely to induce akathisia as they have a weaker binding/blocking property with D2 receptors. 114 Drug-induced akathisia can present as an acute, subacute, chronic, or tardive syndrome.…”

Section: Akathisiamentioning

confidence: 99%

“Unvoluntary” Movement Disorders: Distinguishing between Tics, Akathisia, Restless Legs, and Stereotypies

2023

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Tics, stereotypies, akathisia, and restless legs fall at different places on the spectrum of discrete, unwanted and potentially disabling motor routines. Unlike tremor, chorea, myoclonus, or dystonia, this subgroup of abnormal movements is characterized by the subject's variable ability to inhibit or release undesired motor patterns on demand. Though it may be sometimes clinically challenging, it is crucial to distinguish these “unvoluntary” motor behaviors because secondary causes and management approaches differ substantially. To this end, physicians must consider the degree of repetitiveness of the movements, the existence of volitional control, and the association with sensory symptoms, or cognitive-ideational antecedent. This review aims to summarize the current existing knowledge on phenomenology, diagnosis, and treatment of tics, stereotypies, akathisia, and restless leg syndrome.

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Section: Akathisiamentioning

confidence: 99%

“Unvoluntary” Movement Disorders: Distinguishing between Tics, Akathisia, Restless Legs, and Stereotypies

2023

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“…Newer antipsychotics such as olanzapine, quetiapine and risperidone have a reduced incidence of TDK compared with first generation antipsychotics as they have greater affinity for serotonin receptors than dopamine, but the risk is still substantial . While these medications are classified as antipsychotics, their indications for use have expanded over the years to include conditions such as anxiety, mania, adjunct treatment of alcohol withdrawal, and behavioural disturbances in dementia and autism . Dentists should be aware of the possible adverse effects from these medications as they are being prescribed more frequently and across a wider range of age groups .…”

Section: Drug‐induced Tardive Dyskinesiamentioning

confidence: 99%

“…While these medications are classified as antipsychotics, their indications for use have expanded over the years to include conditions such as anxiety, mania, adjunct treatment of alcohol withdrawal, and behavioural disturbances in dementia and autism . Dentists should be aware of the possible adverse effects from these medications as they are being prescribed more frequently and across a wider range of age groups . Table lists the medicines associated with TDK.…”

Section: Drug‐induced Tardive Dyskinesiamentioning

confidence: 99%

A review and guide to drug‐associated oral adverse effects—Dental, salivary and neurosensory reactions. Part 1

Teoh

Moses

McCullough

2019

J Oral Pathology Medicine

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Numerous adverse drug reactions (ADR) manifest in the oral cavity and orofacial region. Dentists and other health professionals commonly encounter and manage these adverse effects however, due to lack of awareness and training, they are not always recognised as being drug‐induced nor reported to pharmacovigilance agencies. The broad diversity and increasing number of medications for which dental pharmacovigilance is needed can be overwhelming for all health professionals. Thus, the aim of this review and guide was to outline the common medications associated with orofacial side effects so as to improve recognition, management and reporting of ADR. Adverse effects discussed in Part 1 include drug‐induced bruxism, tardive dyskinesia, hairy tongue, gingival enlargement, hypersalivation, xerostomia, tooth discolouration and taste disturbance.

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“…Clinical and registered indications for antidepressants and antipsychotics have expanded over recent years to include conditions such as anxiety, mania, behavioural disturbances of dementia and autism. It is therefore likely that the incidence of these orofacial drug-induced movement disorders will increase as these medicines are prescribed more frequently across a wider patient age range 10…”

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confidence: 99%