Antipsychotic drug use among elderly nursing home residents in the United States

Kamble, Pravin; Chen, Hua; Sherer, Jeffrey T.; Aparasu, Rajender R.

doi:10.1016/j.amjopharm.2008.10.002

Cited by 96 publications

(70 citation statements)

References 34 publications

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“…Notably, the overall rate seems to have changed little in the last twenty years. Our national rate is similar or lower than rates reported in larger international studies in care homes in the US, Canada, Sweden, Finland, Switzerland and Australia and confirms that antipsychotic prescribing in care homes is not a parochial problem for the UK healthcare system but a challenge for all developed populations (Kamble et al, 2008;Lövheim et al, 2008;Rochon et al, 2007;Snowdon et al, 2005;Feng et al, 2009). Community prescribing is less well described and gender, regional and socio-economic differences have not been examined before.…”

Section: Discussionsupporting

confidence: 85%

Antipsychotic prescribing to older people living in care homes and the community in England and Wales

Shah

Carey

Harris

et al. 2010

Int. J. Geriat. Psychiatry

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Despite safety concerns, antipsychotic prescribing is markedly higher in care homes than in the community, and strongly associated with dementia in both settings. In England and Wales, we estimate that 54 000 older care home patients and 50 000 community patients receive antipsychotic medication without a diagnosis of severe mental illness with important implications for health and social services.

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Section: Discussionsupporting

confidence: 85%

Antipsychotic prescribing to older people living in care homes and the community in England and Wales

Shah

Carey

Harris

et al. 2010

Int. J. Geriat. Psychiatry

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“…Criteria from the adjusted Beers list, McLeod's list, and Lindblad's list of clinically important drug-disease interactions are combined and respective data updated [10][11][12][61][62][63][64][65][66][67][68][69]. Some of the inappropriate drugdisease combinations are defined by all three tools, such as NSAIDs in peptic ulcer disease or tricyclic antidepressant in benign prostate hyperplasia.…”

Section: The New Comprehensive Protocolmentioning

confidence: 99%

Potentially inappropriate medications in the elderly: a comprehensive protocol

Matanović

Vlahović‐Palčevski

2012

Eur J Clin Pharmacol

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Elderly patients are at increased risk of drug-related morbidity and mortality. Avoiding the use of potentially inappropriate medications (PIMs) is one of the strategies that has been widely adopted to reduce the harmful consequences of drug use. There are several PIM screening tools available. In this review, we provide an overview of existing screening tools to detect PIMs in the elderly, emphasizing the advantages and disadvantages of each. Combining previously published and adopted tools (adjusted Beers list, French consensus panel, McLeod's list, and Lindblad's list of clinically important drug-disease interactions), we develop a new comprehensive tool that also includes the adjusted Hanlon's and Malone's lists of potentially serious drug-drug interactions in the elderly. In addition to listed PIMs and clinically important drug-drug interactions, alternative therapeutic solutions are suggested. The new protocol differentiates: drugs with an unfavorable benefit/risk ratio (to be avoided regardless of the underlying disease/condition), drugs with a questionable efficacy, and drugs to be avoided with certain diseases/conditions, and provides a list of potentially serious drug-drug interactions. A tool consisting of PIMs and potential drug-drug interactions within the same protocol provides more comprehensive quality assessment of drug-prescribing behavior to the elderly, which in turn may lead to better prescribing practices.

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“…In studies conducted on this population in different countries, a mean prevalence of antipsychotic use varying from 11% to 42% (Champoux et al, 2005;Feng et al, 2009;Hosia-Randell & Pitkala, 2005;Kamble, Chen, Sherer, & Aparasu, 2008;Rochon et al, 2007;Voyer et al, 2005) has been reported. Prevalences of antipsychotic use in Canadian LTCC are among the highest worldwide.…”

Section: Introductionmentioning

confidence: 96%

Effect of an Interdisciplinary Educational Program on Antipsychotic Prescribing Among Residents With Dementia in Two Long-Term Care Centers

Monette

Sourial

et al. 2012

J Appl Gerontol

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The effect of an educational program on antipsychotic prescribing was assessed in two Canadian long-term care centers (LTCC). In each center (Center A residents, n = 258 and Center B residents, n = 191, with dementia at program inception), the rate of change in the odds of using antipsychotics in residents was estimated using mixed-effects logistic regression during a 6-month program period and a 4-month postprogram period, with baseline proportions of use estimated during the 6 months prior to the program. Preprogram proportions of antipsychotic use were 41.6% and 46.2%, respectively. Antipsychotic use decreased during the program in both centers: (odds ratio with 95% CI: 0.943 per week [0.921, 0.965] and 0.969 per week [0.944, 0.994], respectively). During the postprogram period, antipsychotic use increased in Center A (1.039 per week [1.007, 1.072]) but decreased progressively in Center B. The study results suggest the need to implement an ongoing educational program in LTCC.

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Antipsychotic drug use among elderly nursing home residents in the United States

Cited by 96 publications

References 34 publications

Antipsychotic prescribing to older people living in care homes and the community in England and Wales

Antipsychotic prescribing to older people living in care homes and the community in England and Wales

Potentially inappropriate medications in the elderly: a comprehensive protocol

Effect of an Interdisciplinary Educational Program on Antipsychotic Prescribing Among Residents With Dementia in Two Long-Term Care Centers

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