Antipsychotic Drug Use and Screening for Delirium in Mechanically Ventilated Patients in Canadian Intensive Care Units: An Observational Study

Thiboutot, Zoé; Perreault, Marc M.; Rose, Louise; Mehta, Sangeeta; Guenette, Melanie; Cook, Deborah J.; Burry, Lisa

doi:10.4212/cjhp.v69i2.1537

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We believe that the effects of haloperidol on mortality and other important outcomes can only be assessed in a randomised clinical trial (RCT). Such RCTs are warranted as we found a high frequency of the use of haloperidol in our ICU patients with delirium, a finding supported by those of another recent cohort study [40]. Combined with our finding of a 25% prevalence of delirium in ICU patients, there is a pressing need for RCTs assessing the overall benefits and harms of the use of haloperidol in these patients.…”

Section: Figsupporting

confidence: 81%

Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Figsupporting

confidence: 81%

Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additional medications commonly used to manage mechanical ventilation include anticholinergics, steroids, muscle relaxants, and antibiotics (Thiboutot et al, 2016). Anticholinergics are administered to mechanically ventilated patients to reduce airway reflexes caused by mechanical devices and have shown to have good effects on the trachea (Song et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Medication Use and Risk of Delirium in Mechanically Ventilated Patients

Jin

Lee

2019

Clin Nurs Res

View full text Add to dashboard Cite

One of the principal complications in patients in the intensive care unit, particularly in those receiving mechanical ventilation, is medication-induced delirium. The present study aimed to intensively analyze pharmaceutical factors affecting the development of delirium in mechanically ventilated patients using the electronic health records. The present study was designed as a retrospective case–control study. The delirium group included 500 mechanically ventilated patients. The non-delirium group included 2,000 patients who were hospitalized during the same period as the delirium group and received mechanical ventilation. A total of seven types of medications (narcotic analgesics, non-narcotic analgesics, psychopharmaceuticals, sleep aid medications, anticholinergics, steroids, and diuretics), conventionally used to manage mechanical ventilation, were found to be major risk factors associated with the occurrence of delirium. Since these medications are an integral part of managing mechanically ventilated patients, prudent protocol-based medication approaches are essential to decrease the risk of delirium.

show abstract

A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings

Jaworska

Moss

Krewulak

et al. 2022

BMC Health Serv Res

View full text Add to dashboard Cite

Background Antipsychotic medications are frequently prescribed in acute care for clinical indications other than primary psychiatric disorders such as delirium. Unfortunately, they are commonly continued at hospital discharge and at follow-ups thereafter. The objective of this scoping review was to characterize antipsychotic medication prescribing practices, to describe healthcare professional perceptions on antipsychotic prescribing and deprescribing practices, and to report on antipsychotic deprescribing strategies within acute care. Methods We searched MEDLINE, EMBASE, PsycINFO, CINAHL, and Web of Science databases from inception date to July 3, 2021 for published primary research studies reporting on antipsychotic medication prescribing and deprescribing practices, and perceptions on those practices within acute care. We included all study designs excluding protocols, editorials, opinion pieces, and systematic or scoping reviews. Two reviewers screened and abstracted data independently and in duplicate. The protocol was registered on Open Science Framework prior to data abstraction (10.17605/OSF.IO/W635Z). Results Of 4528 studies screened, we included 80 studies. Healthcare professionals across all acute care settings (intensive care, inpatient, emergency department) perceived prescribing haloperidol (n = 36/36, 100%) most frequently, while measured prescribing practices reported common quetiapine prescribing (n = 26/36, 76%). Indications for antipsychotic prescribing were delirium (n = 48/69, 70%) and agitation (n = 20/69, 29%). Quetiapine (n = 18/18, 100%) was most frequently prescribed at hospital discharge. Three studies reported in-hospital antipsychotic deprescribing strategies focused on pharmacist-driven deprescribing authority, handoff tools, and educational sessions. Conclusions Perceived antipsychotic prescribing practices differed from measured prescribing practices in acute care settings. Few in-hospital deprescribing strategies were described. Ongoing evaluation of antipsychotic deprescribing strategies are needed to evaluate their efficacy and risk.

show abstract

Antipsychotic Drug Use and Screening for Delirium in Mechanically Ventilated Patients in Canadian Intensive Care Units: An Observational Study

Abstract: Background: Critically ill patients frequently experience delirium, and antipsychotic drugs are often used to manage symptoms.

Cited by 3 publications

References 30 publications

Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study

Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study

Medication Use and Risk of Delirium in Mechanically Ventilated Patients

A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings

Contact Info

Product

Resources

About