Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes

Lipscombe, Lorraine L.; Lévesque, Linda E.; Gruneir, Andrea; Fischer, Hadas D.; Juurlink, David N.; Gill, Sudeep S.; Herrmann, Nathan; Hux, Janet E.; Anderson, Geoff; Rochon, Paula A.

doi:10.1001/archinternmed.2009.207

Cited by 66 publications

(41 citation statements)

References 35 publications

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“…These databases are generated by Ontario's universal health insurance programs and have been used extensively in health research, including in the postmarketing evaluation of drug and vaccine effects. [24][25][26][27][28][29] …”

Section: Data Sourcesmentioning

confidence: 99%

The Early Benefits of Human Papillomavirus Vaccination on Cervical Dysplasia and Anogenital Warts

Smith¹,

Strumpf

Kaufman³

et al. 2015

Pediatrics

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Section: Data Sourcesmentioning

confidence: 99%

The Early Benefits of Human Papillomavirus Vaccination on Cervical Dysplasia and Anogenital Warts

Smith¹,

Strumpf

Kaufman³

et al. 2015

Pediatrics

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“…Older diabetics who take antipsychotic medications have an increased risk of ending up in the hospital with elevated blood glucose levels, or hyperglycemia [74]. Conversely, treatment with the dopamine precursor L -DOPA in patients with Parkinson’s disease reduces insulin secretion upon oral glucose tolerance test [75].…”

Section: D2rs and Glucose Metabolismmentioning

confidence: 99%

New Insights into the Endocrine and Metabolic Roles of Dopamine D2 Receptors Gained from the <i>Drd2</i><sup>–/–</sup> Mouse

García-Tornadú

Millán²,

Recouvreux³

et al. 2010

Neuroendocrinology

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Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2^–/–) puts forward new insights into the role of the D2R in growth hormone (GH)-releasing hormone-GH regulation, peptides involved in food intake, glucose homeostasis, as well as in prolactinoma development. The expected phenotype of chronic hyperprolactinemia and prolactinoma development was found in the Drd2^–/– mouse, and this model constitutes a valuable tool in the study of dopamine-resistant prolactinomas. Unexpectedly, these mice were growth retarded, and the importance of functional hypothalamic D2Rs in the neonatal period was revealed. In the Drd2^–/– mouse there was a failure of high neonatal GH levels and therefore the expansion of pituitary somatotropes was permanently altered. These mice also had increased food intake, and a sexually dimorphic participation of the D2R in food intake regulation is suggested. The effect described is probably secondary to D2R regulation of prolactin secretion. Furthermore, the negative modulation of D2Rs on α-melanocyte-stimulating hormone release and positive action on the hypothalamic expression of orexins reveals the complex D2R regulation of food intake. Finally, pancreatic D2Rs inhibit glucose-stimulated insulin release. Lack of dopaminergic inhibition throughout development in the Drd2^–/– mouse may exert a gradual deteriorating effect on insulin homeostasis, so that eventually glucose intolerance develops. These results highlight the complex endocrine actions of the D2Rs at different levels, hypothalamus, pituitary or pancreas, which function to improve fitness, reproductive success and survival.

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“…In addition, non-comatose patients were asked to pass urine, which was tested for ketone bodies using a dipstick method. Patients currently using drugs that affect carbohydrate metabolism leading to hyperglycemia, such as corticosteroids, thiazides, sympathomimetic agents, and pentamidine, were excluded from the study [23]. In addition, all patients currently using antipsychotic drugs were also excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Patterns of Hyperglycemia in Patients With Type 2 Diabetes Mellitus With or Without Hypertension, Requiring Emergency Care and Hospitalization

Mungrue

Honore

2015

J Endocrinol Metab

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Background: Hyperglycemia is treatable and preventative cause of both microvascular and macrovascular complications in persons with type 2 diabetes mellitus (T2DM). Hyperglycemia is unequivocally associated with poor outcomes especially in hospitalized patients. The aim of this study therefore is to measure the occurrence of hyperglycemic events particularly in patients with T2DM requiring acute care and subsequent hospitalization with or without hypertension and describe the epidemiological features.

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Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes

Cited by 66 publications

References 35 publications

The Early Benefits of Human Papillomavirus Vaccination on Cervical Dysplasia and Anogenital Warts

The Early Benefits of Human Papillomavirus Vaccination on Cervical Dysplasia and Anogenital Warts

New Insights into the Endocrine and Metabolic Roles of Dopamine D2 Receptors Gained from the <i>Drd2</i><sup>–/–</sup> Mouse

Patterns of Hyperglycemia in Patients With Type 2 Diabetes Mellitus With or Without Hypertension, Requiring Emergency Care and Hospitalization

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