Antipsychotic Drugs and Peripheral Edema: A Review

Örüm, Mehmet Hamdi

doi:10.37990/medr.734181

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common side effects reported include drowsiness and extrapyramidal side effects such as acute akathisia (2). Edema induced by antipsychotics is rarely reported, and the case reports mostly highlight atypical antipsychotics (3). To our knowledge, there is only one case report including a patient with facial and peripheral edema after zuclopenthixol decanoate injection, describing edema after use of zuclopenthixol (4).…”

Section: Introductionmentioning

confidence: 99%

Recurrent pretibial edema associated with zuclopenthixol acetate: A case report

Dagistan¹,

Vahapoglu²

2021

Dusunen Adam

View full text Add to dashboard Cite

Zuclopenthixol acetate is an injectable depot antipsychotic that is effective for 24-48 hours and mainly used for the treatment of acute mania or psychotic episodes. To our knowledge, there is only one case report reporting edema after zuclopenthixol use, which described a patient had suffered from facial and peripheral edema after zuclopenthixol decanoate injection. Here, we present a patient with bipolar disorder who developed bilateral pretibial edema following repeated zuclopenthixol acetate injections. A 53-year-old male patient with no previous medical history presented with manic symptoms. Based on his past psychiatric treatment history, zuclopenthixol acetate was initiated, and three positive pretibial edema developed bilaterally after administration. Although no pathological findings to explain edema were detected, the Naranjo Adverse Reaction Probability Scale showed a "probable" relationship of zuclopenthixol and edema with a score of 8. Peripheral edema may develop due to various common medical conditions including antipsychotic drugs and can be life-threatening. Although the exact mechanisms of peripheral edema due to antipsychotic use are still unknown, further studies may shed further light on these mechanisms.

show abstract

Section: Introductionmentioning

confidence: 99%