BackgroundCapturing service users’ perspectives can highlight additional and different concerns
to those of clinicians, but there are no up to date, self-report psychometrically sound
measures of side effects of antipsychotic medications.AimTo develop a psychometrically sound measure to identify antipsychotic side effects
important to service users, the Maudsley Side Effects (MSE) measure.MethodAn initial item bank was subjected to a Delphi exercise (n = 9) with
psychiatrists and pharmacists, followed by service user focus groups and expert panels
(n = 15) to determine item relevance and language. Feasibility and
comprehensive psychometric properties were established in two samples (N43 and N50). We
investigated whether we could predict the three most important side effects for
individuals from their frequency, severity and life impact.ResultsMSE is a 53-item measure with good reliability and validity. Poorer mental and physical
health, but not psychotic symptoms, was related to side-effect burden. Seventy-nine
percent of items were chosen as one of the three most important effects. Severity,
impact and distress only predicted ‘putting on weight’ which was more distressing, more
severe and had more life impact in those for whom it was most important.ConclusionsMSE is a self-report questionnaire that identifies reliably the side-effect burden as
experienced by patients. Identifying key side effects important to patients can act as a
starting point for joint decision making on the type and the dose of medication.