Antipsychotic prescribing practice among child psychiatrists and community paediatricians

Otasowie, John; Duffy, Rachel; Freeman, Jenny; Hollis, Chris

doi:10.1192/pb.bp.108.024000

Cited by 10 publications

(9 citation statements)

References 12 publications

(20 reference statements)

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“…It is noted that a growing number of antipsychotic prescriptions among children and adolescents are for 'off-label' use in the treatment of non-psychotic conditions such as conduct and behavioural disorders (Otasowie et al, 2010). Although accepted as commonplace in the general adult setting, the extent of off-label prescribing among children and adolescents in the UK is unknown (Baldwin and Kosky, 2007).…”

Section: Introductionmentioning

confidence: 99%

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Woods¹,

Shannon²,

Davidson³

et al. 2015

Ir. j. psychol. Med.

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Objective: to report new prescriptions of psychotropic medications among adolescents presenting with new onset psychotic symptoms during a five-year period. Results: A total of 100 patients (88.5%) were prescribed some form of psychotropic medication.Over three-quarters of patients received an antipsychotic as their first medication. Risperidone (45.8%), olanzapine (24.0%) and chlorpromazine (12.5%) were the most commonly prescribed first-line antipsychotic medications. Of a total of 160 antipsychotic prescriptions, 81 (50.6%) were off-label. Prescriptions were most likely to have been deemed off-label due to medications not being licensed in under-18s (71.6% of off-label prescriptions) but other reasons were medications being used outside licensed age ranges (23.5%) and outside licensed indications (4.9%).Conclusions: This is the first study examining psychotropic prescribing patterns in a complete sample of all children and adolescents presenting with early onset psychotic episodes in a single geographical area. The observation of risperidone as the most commonly-prescribed antipsychotic was in keeping with previous studies in child and adolescent populations. Rates of off-label prescribing were lower than previously observed although our study was the first to investigate offlabel prescribing solely in children and adolescents presenting with psychotic symptoms.2

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Section: Introductionmentioning

confidence: 99%

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Woods¹,

Shannon²,

Davidson³

et al. 2015

Ir. j. psychol. Med.

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“…In the past decade there has been substantial increase in the use of antipsychotic medication in children and adolescents (Vitiello et al, 2009). Studies in both UK (Clark, 2004, Otasowie et al, 2010) and US (Patel et al, 2005) show a switch from first line use of first generation antipsychotics (FGA) such as Haloperidol and Sulpiride to second generation antipsychotics (SGA) such as Olanzapine, Risperidone and Amisulpride. The recently completed baseline for the Prescribing Observatory for Mental Health‐UK study of antipsychotic medication in children and adolescents showed 90% of prescriptions were of SGAs (Prescribing Observatory for Mental Health, 2010).…”

Section: Background and Brief Literature Reviewmentioning

confidence: 99%

“…For a period SGAs became the first line choice due to presumed better tolerability and improved likelihood of better concordance and outcome (Otasowie et al, 2010; Patel et al, 2005) This is now being increasingly questioned (Varley & McClellan 2009; Lewis & Lieberman, 2008). Large trials in both the UK and US (i.e.…”

Section: Background and Brief Literature Reviewmentioning

confidence: 99%

“…In the past decade there has been substantial increase in the use of antipsychotic medication in children and adolescents (Vitiello et al, 2009). Studies in both UK (Clark, 2004, Otasowie et al, 2010 and US (Patel et al, 2005) For a period SGAs became the first line choice due to presumed better tolerability and improved likelihood of better concordance and outcome (Otasowie et al, 2010;Patel et al, 2005) This is now being increasingly questioned (Varley & McClellan 2009;Lewis & Lieberman, 2008). Large trials in both the UK and US (i.e.…”

mentioning

confidence: 99%

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Antipsychotic prescribing: old wine in new bottles?

Imran

Datta

Vincent

et al. 2011

Child and Adolescent Mental Health

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Background: Recent research suggests first generation antipsychotic medications may be no less effective or tolerated than second generation antipsychotics. Aims: To review prescribing practices in UK adolescent mental health settings. Method: A review of literature and a postal survey (structured questionnaire) of clinicians in UK adolescent mental health settings (80 general and specialised in‐patient units) were conducted. Results: Second generation antipsychotics remain the drug of first choice for most UK clinicians (based on a survey response rate of 40%). Conclusions: Guidelines for antipsychotic use in adolescents need updating. Clinicians who qualified in the last 10 years may need specific training and experience in use of first generation antipsychotics.

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“…P Background: Psychotropic medication is increasingly used in children to treat psychiatric symptoms or illnessess [1] and behaviours associated with autistic spectrum disorders [2]. Child and adolescent psychiatrists report that stimulants or antipsychotics, namely the atypical antipsychotics, are the medicines they use most frequently in this population [3].…”

mentioning

confidence: 99%

Profiling psychotropic discharge medication from a children’s psychiatric ward

Akram

2015

Int J Clin Pharm

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Antipsychotic prescribing practice among child psychiatrists and community paediatricians

Cited by 10 publications

References 12 publications

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Antipsychotic prescribing: old wine in new bottles?

Profiling psychotropic discharge medication from a children’s psychiatric ward

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