Antipsychotics do not affect platelet serotonin in schizophrenic patients

Šagud, Marina; Nikolac, Matea; Mihaljević-Peleš, Alma; Nedić, Gordana; Ćusa, Bjanka Vuksan; Mustapić, Maja; Marčinko, Darko; Jakovljević, Miro; Mück‐Šeler, Dorotea; Pivac, Nela

doi:10.2478/s13380-012-0001-5

Cited by 1 publication

(1 citation statement)

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“…However, patients taking this type of medication (eg, citalopram) were excluded from our study. Some of the recruited patients were, however, treated with olanzapine, a serotonin-dopamine receptor antagonist used in the treatment of schizophrenia and other psychotic disorders, but this drug does not have a significant effect on platelet serotonin concentration 48…”

Section: Discussionmentioning

confidence: 99%

Platelet abnormalities in Huntington’s disease

Denis

Lamontagne‐Proulx

St‐Amour

et al. 2018

J Neurol Neurosurg Psychiatry

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Huntington’s disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood–brain barrier (BBB) leakage.ObjectivesSeeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells.MethodsWe assessed the functional status of platelets by performing ELISA, western blot and RNA sequencing in a cohort of 71 patients and 68 age- and sex-matched healthy control subjects. We further performed haemostasis and platelet depletion tests in the R6/2 HD mouse model.ResultsOur findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis.ConclusionTaken together, our results provide a better understanding for the impact of mHtt on platelet function.

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Section: Discussionmentioning

confidence: 99%