Antipsychotika in der Schwangerschaft: eine systematische Übersichtsarbeit

Hillemacher, Thomas; Simen, Susanne; Rehme, Marie-Kathrin; Frieling, Helge

doi:10.1007/s00115-020-01006-8

Nervenarzt

2020

DOI: 10.1007/s00115-020-01006-8

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Antipsychotika in der Schwangerschaft: eine systematische Übersichtsarbeit

Thomas Hillemacher

Susanne Simen

Marie-Kathrin Rehme

et al.

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Cited by 2 publications

References 60 publications

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Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review

Sani,

Callovini,

Ferrara

et al. 2024

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There is much debate about continuing antipsychotic medication in patients who need it when they become pregnant because benefits must be weighed against potential teratogenic and malformation effects related to antipsychotics themselves. To address this, we conducted a systematic review on the PubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy: (toxicity OR teratogenicity OR malformation* OR "birth defect*" OR "congenital abnormality" OR "congenital abnormalities" OR "brain changes" OR "behavioral abnormalities" OR "behavioral abnormalities") AND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR perinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The oldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics, especially the second-generation antipsychotics, were devoid of teratogenic potential, while few studies were inconclusive and recommended replication. Most authoritative articles were from the Boston area, where large databases were implemented to study the malformation potential of psychiatric drugs. Other reliable databases are from Northern European registers. Overall conclusions are that antipsychotics are no more related to malformations than the disorders themselves; most studies recommend that there are no reasons to discontinue antipsychotic medications in pregnancy.

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Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review

Sani,

Callovini,

Ferrara

et al. 2024

View full text Add to dashboard Cite

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Korean Medication Algorithm Project for Bipolar Disorder 2022: Treatment Strategy According to Safety and Tolerability

Park¹,

Bahk

Woo

et al. 2022

J Korean Neuropsychiatr Assoc

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Antipsychotika in der Schwangerschaft: eine systematische Übersichtsarbeit

Cited by 2 publications

References 60 publications

Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review

Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review

Korean Medication Algorithm Project for Bipolar Disorder 2022: Treatment Strategy According to Safety and Tolerability

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