Antipsychotiques et troubles bipolaires

Vacheron-Trystram, Marie-Noëlle; Braitman, Abby L.; Cheref, S.; Auffray, L.

doi:10.1016/s0013-7006(04)95456-5

Cited by 38 publications

(9 citation statements)

References 22 publications

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“…The presence of antiepileptic drugs such as gabapentin, both in men and women under 65 years of age, is remarkable. This drug might be used off-label as a modulator of behaviour disorders in psychotic patients [23,24]; the drug might also be administered as an adjuvant medication for pain uncontrollable with regular analgesia.…”

Section: Resultsmentioning

confidence: 99%

Polypharmacy Patterns: Unravelling Systematic Associations between Prescribed Medications

et al. 2013

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ObjectivesThe aim of this study was to demonstrate the existence of systematic associations in drug prescription that lead to the establishment of patterns of polypharmacy, and the clinical interpretation of the associations found in each pattern. MethodsA cross-sectional study was conducted based on information obtained from electronic medical records and the primary care pharmacy database in 2008. An exploratory factor analysis of drug dispensing information regarding 79,089 adult patients was performed to identify the patterns of polypharmacy. The analysis was stratified by age and sex. ResultsSeven patterns of polypharmacy were identified, which may be classified depending on the type of disease they are intended to treat: cardiovascular, depression-anxiety, acute respiratory infection (ARI), chronic obstructive pulmonary disease (COPD), rhinitis-asthma, pain, and menopause. Some of these patterns revealed a clear clinical consistency and included drugs that are prescribed together for the same clinical indication (i.e., ARI and COPD patterns). Other patterns were more complex but also clinically consistent: in the cardiovascular pattern, drugs for the treatment of known risk factors—such as hypertension or dyslipidemia—were combined with other medications for the treatment of diabetes or established cardiovascular pathology (e.g., antiplatelet agents). Almost all of the patterns included drugs for preventing or treating potential side effects of other drugs in the same pattern.ConclusionsThe present study demonstrated the existence of non-random associations in drug prescription, resulting in patterns of polypharmacy that are sound from the pharmacological and clinical viewpoints and that exist in a significant proportion of the population. This finding necessitates future longitudinal studies to confirm some of the proposed causal associations. The information discovered would further the development and/or adaptation of clinical patient guidelines to patients with multimorbidity who are taking multiple drugs.

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Section: Resultsmentioning

confidence: 99%

Polypharmacy Patterns: Unravelling Systematic Associations between Prescribed Medications

et al. 2013

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“…16 Although AP are effective in preventing relapse, their long-term use results in unwanted metabolic effects, and the development of movement disorders cannot be ruled out. 20 In 2008, the European College of Neuropsychopharmacology (ECNP) indicated that long-term combination medications with AP could be justified in patients who did not achieve full remission, those who were more severely psychotic, those who showed mixed states, and those who were rapidly cycling. 21 Our results could be interpreted as reflecting such concerns, and they support the position that a lower dose of an AP is enough to maintain the remission state.…”

Section: Discussionmentioning

confidence: 99%

Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments

Song

Kwon

Bahk

et al. 2015

Psychiatry Clin Neurosci

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Aims:We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments.Methods: Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score ≤ 2 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months.Results: A total of 340 bipolar disorder patients were selected. During the maintenance period, more than half of the patients (192, 56.5%) took a mood stabilizer (MS) + antipsychotic (AP) combination. Among the MS, valproate (149, 43.8%) was most prescribed, and lithium (98, 28.8%) was second, but as patients moved into maintenance treatment, lithium use decreased, and the use of lamotrigine (86, 25.3%) increased. Preferred AP were quetiapine (125, 36.8%), aripiprazole (67, 19.7%), risperidone (48, 14.1%), and olanzapine (39, 11.5%). The use of olanzapine in maintenance was greatly decreased compared with that during acute treatment (67, 19.7%). Most patients did not take an antidepressant (AD), but the proportion using one or more AD was increased during maintenance (17.9% to 30.3%), and bupropion (28, 8.2%) was the preferred AD. Doses were decreased in all drugs, but lamotrigine was maintained at a dose of 133.2 ± 68.5 mg/day.

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“…These authors suggested that excessive daytime sleepiness reported by bipolar patients, rather than a documented hypersomnia, might be due to a lack of motivation and to anergia facilitating or mimicking sleep (Billiard, Dolenc, Aldaz, Ondze, & Besset, ; Kaplan & Harvey, ). Daytime sleepiness found in our sample might also be a side effect of medication (Vacheron‐Trystram, Braitman, Cheref, & Auffray, ). These findings highlighted the importance of exploring daytime sleepiness in bipolar patients during remission (Geoffroy et al, ).…”

Section: Discussionmentioning

confidence: 81%

The link between sleep disturbances and suicidal thoughts and behaviors in remitted bipolar I patients

et al. 2019

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Objective We aimed to evaluate the links between different sleep parameters and suicidal ideation and behavior in remitted bipolar I patients. Methods One hundred eight remitted bipolar I patients were recruited from the psychiatry department of Razi Hospital. The third item of the “Hamilton Depression Rating Scale” was used to evaluate current suicidal behaviors. Circadian typology, daytime sleepiness and sleep quality were evaluated using the “Horne and Ostberg Morningness‐Eveningness Questionnaire,” the “Epworth Sleepiness Scale,” and the “Pittsburgh Sleep Quality Index,” respectively. Results Current suicidal ideation and behavior were significantly associated with circadian typology, daytime sleepiness, and sleep quality. After controlling for demographic variables (age and gender) and psychosocial factors (depression and substance use), suicidal ideation significantly contributed to sleep quality. Depression was a significant predictor within the second step when entered with other psychosocial variables; however, once suicide variables were included, depression was no longer a significant predictor. Conclusions An evaluation of sleep's quality should be included in the suicide risk assessment of bipolar I patients.

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Antipsychotiques et troubles bipolaires

Cited by 38 publications

References 22 publications

Polypharmacy Patterns: Unravelling Systematic Associations between Prescribed Medications

Polypharmacy Patterns: Unravelling Systematic Associations between Prescribed Medications

Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments

The link between sleep disturbances and suicidal thoughts and behaviors in remitted bipolar I patients

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