Antipyretic analgesics

Prescott, L.F.

doi:10.1016/s0378-6080(80)80012-2

Cited by 1 publication

(2 citation statements)

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“…Patients with acute rheumatic fever were first noted to have abnormal liver function tests by Nydick, Tang, Stollerman, Wroblewski & LaDue (1955), and a direct association with salicylate therapy was soon established (Manso, Taranta & Nydick, 1956). During the next 15 years there was only one further report (Okumura, Ichikawa, Aramaki & Obayashi, 1966), but in the past decade several hundred cases have been described, and the condition is being recognized with increasing frequency (see reviews by Prescott, 1975;1977;1979a;1980;Schaller, 1978).…”

Section: Aspirin and Salicylatesmentioning

confidence: 99%

“…The reactive metabolite is produced by cytochrome P450 mixed function oxidase, and the hepatotoxicity of paracetamol depends on the activity of these enzymes and the availability of glutathione (Mitchell, Jollow, Potter, Davis, Gillette & Brodie, 1973; Potter, Davis, Mitchell, Jollow, Potter, Gillette & Brodie, 1973b). The clinical and biochemical features of paracetamol poisoning have been reviewed (Prescott, 1975;1977;1979a;1979b;1980). There are no specific early features since consciousness is not impaired and clinical and biochemical evidence of liver injury is delayed with maximum abnormalities of liver function tests usually occurring 3-5 d after ingestion.…”

Section: Paracetamolmentioning

confidence: 99%

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Hepatotoxicity of mild analgesics.

Prescott¹

1980

Brit J Clinical Pharma

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1 Hepatotoxicity is rare when mild analgesics are used in normal therapeutic doses. 2 The potential of aspirin and salicylates to cause hepatotoxicity has been only recently recognized. 3 Salicylate hepatitis is often asymptomatic, and may only be revealed by finding elevated levels of aminotransferases. 4 Most cases have occurred in children or young adults with connective tissue diseases, who take high doses of salicylates for long periods. 5 Hepatic injury is not recognized as a complication of acute aspirin poisoning. 6 Following overdosage of paracetamol, a toxic intermediate metabolite causes acute hepatic necrosis which may be fatal. 7 Cysteamine, methionine and N‐ acetylcysteine confer protection against this severe liver damage, but the time between overdosage and treatment is critical. 8 The chronic therapeutic use of paracetamol should be considered a potential but very rare cause of active chronic hepatitis. 9 There is no clear evidence of phenacetin hepatotoxicity in man. 10 Phenylbutazone may cause liver injury and other analgesics can cause hypersensitivity reactions in which the liver is involved.

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