Antipyretic and antinociceptive effects of<i>Nauclea latifolia</i>root decoction and possible mechanisms of action

Taïwé, Germain Sotoing; Bum, Elisabeth Ngo; Talla, Emmanuel; Dimo, Théophile; Weiss, Norbert; Sidiki, Neteydji; Dawe, Amadou; Moto, Fleur Clarisse Okomolo; Dzeufiet, Paul Désiré Djomeni; Waard, Michel De

doi:10.3109/13880209.2010.492479

Cited by 77 publications

(51 citation statements)

References 36 publications

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“…Acetic acid (0.60%, 10 ml/kg) was injected i.p. and the number of abdominal constrictions (writhings) during the following 30 min period was observed (Taïwe et al, 2011). A significant reduction in the number of abdominal constrictions by any treatment compared with vehicle treated animals was considered as an antinociceptive response.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents

Taïwé

Bum

Talla

et al. 2012

Journal of Ethnopharmacology

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The results confirm the popular use of Crassocephalum bauchiense as an antinociceptive, and contribute to the pharmacological knowledge of this species because it was shown that the aqueous extract and the alkaloid fraction of Crassocephalum bauchiense produced dose related antinociception in models of chemical and thermal nociception through mechanisms that involve an interaction with opioidergic pathway.

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Section: Drugs and Chemicalsmentioning

confidence: 99%

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents

Taïwé

Bum

Talla

et al. 2012

Journal of Ethnopharmacology

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“…Rectal temperature was recorded with an electronic thermometer at predetermined times in groups of mice before and after (0.5, 1, 2, 3 and 24 h) the administration of either vehicle or the extracts of Crassocephalum bauchiense. Pre-drug recording served as the reference point for the determination of the temperature change (Taïwe et al, 2011).…”

Section: Primary Observation Testmentioning

confidence: 99%

Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents

Taïwé

Bum

Talla

et al. 2012

Journal of Ethnopharmacology

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“…In most parts of the African countries including Nigeria, the plant's stem, bark, root and leaves are used in treatment of malarial infection [8]. The effect of N. latifolia such as lowering blood pressure, antidiabetic, anticonvulsant, antipyretic, analgesic, anxiolytic and sedative properties have been reported [7,[9][10][11] . Nevertheless, the ability of N. latifolia leaf extract to eliminate both hepatic and cerebral malarial parasite and reduce oxidative damage to tissues in Plasmodium berghei (P. berghei) infected mice is yet to be experimentally documented.…”

Section: Introductionmentioning

confidence: 99%

Nauclea latifolia aqueous leaf extract eliminates hepatic and cerebral Plasmodium berghei parasite in experimental mice

Onyesom

Osioma²,

Okereke

2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To assess the effects of hot water leaf extract of Nauclea latifolia (N. latifolia) on antioxidant status, lipid peroxidation values and parasite levels in hepatic and brain tissue of experimental mice (BALB/c) infected with Plasmodium berghei (P. berghei) malaria. Methods: Forty nine mice were divided into seven groups (n = 7) and used for the study. Group A (control) were given 0.2 mL/kg phosphate buffer saline; Group B mice were infected with P. berghei and treated with phosphate buffer saline. Groups C and D mice were also infected but treated with 200 and 300 mg/kg body weight of leaf extract respectively. Groups E and F mice were not infected, but received 200 and 300 mg/kg of leaf extract respectively. Group G mice were infected and treated with chloroquine (5 mg/ kg). Liver and brain tissues of mice were prepared for both biochemical assay and microscopic examination. Results: Results showed that P. berghei malaria infection induced oxidative stress in both liver and brain tissues as evidenced by the significant (P < 0.05) decrease in antioxidants: superoxide dismutase, reduced glutathione and catalase. These reductions perhaps caused compromise in membrane integrity as indicated by the significant increase in lipid peroxidation product malondialdhyde. Malaria parasites were also identified in these tissues. However, N. latifolia treatment eliminated the parasites in tissues and protected them from oxidative damage even better than chloroquine treatment did, whose anti-malarial potency also cleared tissue parasites. The measurement of protection by N. latifolia against damage was strengthened by the insignificant micro structural alterations. Conclusions: The bioactive phytochemical(s) in N. latifolia should be structured and the mechanism(s) of its antimalarial tendency should be further investigated.

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Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Cited by 77 publications

References 36 publications

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents

Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents

Nauclea latifolia aqueous leaf extract eliminates hepatic and cerebral Plasmodium berghei parasite in experimental mice

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