Antipyrine Clearance and α1-Acid Glycoprotein Levels after Isotretinoin

Abstract

<jats:p> Eight male subjects aged 18-24 years were treated with 0.5 mg of isotretinoin day<jats:sup>-1</jats:sup> kg<jats:sup> -1</jats:sup>. After 4 weeks levels of cholesterol (P &lt; 0.05) and triglyceride (P &lt; 0.05) were increased and levels of high-density lipoprotein (HDL)-cholesterol were decreased (P &lt; 0.05). Concentrations of aspartate aminotransferase (P &lt; 0.01) and γ-glutamyltranspeptidase (P &lt; 0.01) were higher after treatment; increased alkaline phosphatase and a reduction in bilirubin levels did not reach statistical significance. Values for thyroxine were reduced after isotretinoin and free thyroxine index was lower (P &lt; 0.01). Measurements of salivary clearance of antipyrine and levels of α<jats:sub> 1</jats:sub>-acid glycoprotein were lower after treatment but these differences did not reach statistical significance. The findings suggest that there is a small decrease in hepatic microsomal-enzyme activity after isotretinoin and that the unwanted effects on lipids, liver and thyroid function are unlikely to be due to hepatic microsomal-enzyme induction. </jats:p>

Decreased plasma folate concentration in young and elderly healthy subjects after a short‐term supplementation with isotretinoin

“…Blood level of cholesterol and activity of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and alkaline phosphatase also increased, but the changes were not significant. Similar findings have been previously reported in young male subjects after comparable supplementation with isotretinoin 15,17 . Function of kidney, in addition to liver, has been found to be altered by this condition in rats, 18,19 but rarely in humans 20 .…”

“…Similar findings have been previously reported in young male subjects after comparable supplementation with isotretinoin. 15,17 Function of kidney, in addition to liver, has been found to be altered by this condition in rats, 18,19 but rarely in humans. 20 Our current data did not favour kidney and liver dysfunction in the volunteers because, in spite of significant changes, blood levels of creatinine, urea, γ -GT and triglycerides remained within the normal ranges.…”