Antiradiation agents. Substituted 2-pyridyloxy and 2-quinolyloxy derivatives of S-2-(alkylamino)ethyl hydrogen thiosulfates and 3-alkylthiazolidines and substituted 2-pyridyloxy derivatives of 2-(alkylamino)ethanethiols and corresponding disulfides

Abstract

The height of the reduction wave is proportional to the concentration of the nitrofuran compound. The logarithm of the heights was plotted against the time in a diagram of the type presented in Figure 1, from which per cent reduced compound after 1 hr reaction could be calculated. The values in Table I1 are the mean values with calculated 95% confidence limits assuming the same variation in measurements with all compounds. skilled technical assistance of Miss A. Notrman and Mr. 0. Hall (Chemistry), Mr. E. Johansson (Pharmacology), and Mrs. E. Olsson and Mrs. A. Enqvist (Microbiology). We also thank Dr. M. Ceska for help with the enzyme preparations and Messrs. R. Anderson and R. Lofstedt for performing the metabolic studies. We are grateful to Mr. A. Lanner for the administration of the clinical trials and to Mr. Goran Nilsson for help with the statistical calculations.

Adsorptive and Catalytic Cathodic Stripping Voltammetric Determination of Timonacic

“…The newly appeared peak was the result of ligand as a nickel complex rather than as a mercury complex. The proposed mechanism of catalytic reduction is as follows: 1. accumulation of mercury thiolate derivative of (TC) Hg + 2TC → Hg(TC) 2 The reaction stoichiometry was determined by applying Asmus method. It was found that the ratio of (TC) : nickel is 2 : 1 (Fig.…”

“…The timonacic (TC) molecule has a biological significance; its importance arises from the fact that the thiazolidine ring is an integral part of pharmacologically active compounds like penicillins and antiradiation drugs [1,2]. It plays an important role in hepatotoxicity protection, and is used as an adjuvant in the treatment of some kind of hepatic diseases, psoriasis and acne [3].…”

NTP Technical Report on the Toxicity Studies of o-Chloropyridine (CASRN 109-09-1) Administered Dermally and in Drinking Water to F344/N Rats and B6C3F1/N Mice

“…Prospective metabolites of o-chloropyridine, N-methylpyridine-2-mercapturic acid, pyridine-Noxide-2-mercapturic acid, 2-methylthiopyridine, 2-methylthiopyridine-N-oxide, 2-chloro-5pyridinol, and 2-chloro-4-pyridinol were synthesized in-house using methods of Talik 58 , Beak and Lee 59 , Westland et al 60 , and Kohrman et al 61 .…”

4‐(Trifluoromethyl)quinoline Derivatives

“…However, if aniline and ethyl trifluoroacetate are very briefly kept at 235 °C, the 4,4,4‐trifluoroacetoacetanilide (or the enol‐like tautomer) is obtained. Subsequent treatment with concentrated sulfuric acid at 95 °C yields the 4‐trifluoromethyl‐2‐quinolinone 5−7 …”