Antiradical Activity of 1,4-and 1,2-Benzene Dicarboxyl Esters From Deinbollia Pinnata Leaves

Rufai, Yakubu; Basar, Norazah; Chandren, Sheela; Suleiman, Kolawole Yusuf; Yinusa, I.

doi:10.46602/jcsn.v45i6.563

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…1 and Tables 2 , 3 and 4 ) from Nauclea latifolia roots were selected for docking against two target proteins implicated in the pathogenesis of malaria: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1) and Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) and compared with chloroquine drugs. Moreover, some researchers had earlier reported the biological activities of some of the characterized compounds as follows: betulinic acid has reported antiplasmodial activity [ 5 ], ursolic acids have anti-inflammatory, antioxidant, antiplasmodial, antidiabetic, and anticancer activities [ 10 ], 3-methyl glucose can inhibit the uptake of glucose in Plasmodium falciparum [ 20 ] , and 1,2-benzene dicarboxylic acid diisoctylester has been reported for its antioxidant scavenging activity towards DPPH [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Asanga,

Ekpo,

Edeke

et al. 2024

BMC Complement Med Ther

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Background Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the disease’s high fatality rate. This work identified the phytochemical components of Nauclea latifolia roots and docked the chemical compounds against target proteins, and examined the in vivo antiplasmodial effect of the roots on Plasmodium berghei-infected mice. Methods Standard protocols were followed for the collection of the plant’s roots, cleaning, and drying of the roots, extraction and fraction preparation, assessment of the in vivo antiplasmodial activity, retrieval of the PfEMP-1 and PfPKG proteins, GCMS, ADME, and docking studies, chromatographic techniques were employed to separate the residual fraction’s components, and the Swis-ADME program made it possible to estimate the drug’s likeness and pharmacokinetic properties. The Auto Dock Vina 4.2 tool was utilized for molecular docking analysis. Results The residual fraction showed the best therapeutic response when compared favorably to amodiaquine (80.5%) and artesunate (85.1%). It also considerably reduced the number of parasites, with the % growth inhibition of the parasite at 42.8% (D2) and 83.4% (D5). Following purification, 25 compounds were isolated and characterized with GCMS. Based on their low molecular weights, non-permeation of the blood–brain barrier, non-inhibition of metabolizing enzymes, and non-violation of Lipinski’s criteria, betulinic and ursolic acids were superior to chloroquine as the best phytochemicals. Hence, they are lead compounds. Conclusion In addition to identifying the bioactive compounds, ADME, and docking data of the lead compounds as candidates for rational drug design processes as observed against Plasmodium falciparum target proteins (PfEMP-1 and PfPKG), which are implicated in the pathogenesis of malaria, the study has validated that the residual fraction of N. latifolia roots has the best antiplasmodial therapeutic index.

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Section: Discussionmentioning

confidence: 99%

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Asanga,

Ekpo,

Edeke

et al. 2024

BMC Complement Med Ther

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“…Isolated compounds are classified as flavonoids, coumarins, phenolics, terpenes, esters, ethers, and hydrocarbons [31,34,35]. Plants are a major segment of biodiversity affected by many living and non-living components with their medicinal values.…”

Section: Introductionmentioning

confidence: 99%

TRANSITIONAL STATES PARTICIPATION IN PHOTODEGRADATION OF METHYL ORANGE FROM GREEN TITANIUM NANOPARTICLES SYNTHESIS USING Deinbollia pinnta LEAVES

Rufai¹,

Basar²,

Suleiman³

et al. 2022

JCSN

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The surface chemistry of nanostructures concerning their smaller sizes, unique optical and electronic properties continue to benefit organic medicinal chemistry and biosynthesis of active titania nanoparticles with metabolites present in plant extracts. Deinbollia pinnata ethyl acetate leave extracts with sol-gel method afforded titania nanoparticles (TiO2 NPs-anatase) with photodegradation performance at 98.7% of methyl orange (MO) conversion within 150 mins. Together with observed participation of π-π* transition state more than that of η-π* state. The GC-MS spectrum revealed classes of compounds which include long-chain fatty acids, galloyl ester, long-chain esters, tetraterpenoids, triterpenoids, sesquiterpenoid terpenoid (isoprenoids) with a correlation maximum of stigmasterol (94%)as phytochemical contents of the crude extracts. The physiochemical analysis using X-ray diffraction (XRD) showed average crystallite size in the range of 19 – 21 nm, field emission scanning electron microscopy (FESEM) displayed uniform semi-spherical shape in the size range of 33 – 48 nm, energy dispersive X-ray (EDX) spectra depicted main elements of Ti (61 Wt.%) and O (35 Wt.%), UV-Vis spectroscopy exhibited band-gap energy of 3.2 eV, nitrogen sorption analysis specified type IV isotherm and BET surface area of 31.77 m2/g. The super-striking green TiO2 NPs photodegradation in this work with wide-ranged transitional states involvement, can, in turn, be used as bio-mediated TiO2 NPs in medicinal chemistry to enhance pharmacokinetics, pharmacological properties and replace chemical agents thereby reducing side effects at drug delivery site actions. Thus, natural products continue to integrate research advances and innovation.

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Antiradical Activity of 1,4-and 1,2-Benzene Dicarboxyl Esters From Deinbollia Pinnata Leaves

Cited by 2 publications

References 12 publications

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

TRANSITIONAL STATES PARTICIPATION IN PHOTODEGRADATION OF METHYL ORANGE FROM GREEN TITANIUM NANOPARTICLES SYNTHESIS USING Deinbollia pinnta LEAVES

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