Antiretroviral Therapy Adherence Did Not Differ between Thai Children with Biological and Those with Nonbiological Parents

Safreed-Harmon, Kelly; Siripong, Arida; Kerr, Stephen J.; Gruskin, Sofia; Pancharoen, Chitsanu; Ananworanich, Jintanat

doi:10.1086/520784

Cited by 10 publications

(12 citation statements)

References 4 publications

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“…These findings differ from previous studies done in smaller cohorts within resource-limited settings, in which orphan status was not significantly associated with ART nonadherence. 13,16,33,34 These findings also differ from results of studies done in the United States and Europe where having a foster parent or nonbiological caregiver is associated with a higher rate of ART adherence. [45][46][47] However, having a foster parent or nonbiological caregiver in the United States or Europe may reflect a situation in which a parent is unable to provide adequate care, rather than a situation where the parent is dead.…”

Section: Discussioncontrasting

confidence: 90%

“…25,27,[30][31][32] In some studies from resource-limited settings, orphan status has been associated with ART nonadherence, 20,22 whereas other studies have not found a significant correlation between nonadherence and orphan status. 13,16,33,34 The particular orphan care system may play a role; one study suggests that orphans with institutional caregivers have better adherence than those with noninstitutional caregivers. 22 The variable effects of orphan status on dimensions of HIV care and outcomes merit further examination.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Antiretroviral and Clinic Adherence With Orphan Status Among HIV-Infected Children in Western Kenya

Vreeman

Wiehe²,

Ayaya

et al. 2008

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Section: Discussioncontrasting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association of Antiretroviral and Clinic Adherence With Orphan Status Among HIV-Infected Children in Western Kenya

Vreeman

Wiehe²,

Ayaya

et al. 2008

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Better or similar adherence when ART is administered by foster parents and relatives has been reported. [14][15][16][17][18] However, our study found poorer adherence among orphaned children, suggesting inadequate care of these children by their extended families. Better adherence among non-orphans might also be because both parent and child were being treated at the same ART centre.…”

Section: Discussioncontrasting

confidence: 61%

Adherence to antiretroviral therapy and its correlates among HIV-infected children at an HIV clinic in New Delhi

Bhattacharya

Dubey

2011

Annals of Tropical Paediatrics

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“…To measure ART adherence, we counted the remaining pills or syrups which participants presented on the day of the interview [22], [23]. Pill count measurement was used because of its objective and quantifiable advantage [24].…”

Section: Methodsmentioning

confidence: 99%

High Risk of ART Non-Adherence and Delay of ART Initiation among HIV Positive Double Orphans in Kigali, Rwanda

Kikuchi

Poudel

Muganda³

et al. 2012

PLoS ONE

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BackgroundTo reduce HIV/AIDS related mortality of children, adherence to antiretroviral treatment (ART) is critical in the treatment of HIV positive children. However, little is known about the association between ART adherence and different orphan status. The aims of this study were to assess the ART adherence and identify whether different orphan status was associated with the child’s adherence.MethodsA total of 717 HIV positive children and the same number of caregivers participated in this cross-sectional study. Children’s adherence rate was measured using a pill count method and those who took 85% or more of the prescribed doses were defined as adherent. To collect data about adherence related factors, we also interviewed caregivers using a structured questionnaire.ResultsOf all children (N = 717), participants from each orphan category (double orphan, maternal orphan, paternal orphan, non-orphan) were 346, 89, 169, and 113, respectively. ART non-adherence rate of each orphan category was 59.3%, 44.9%, 46.7%, and 49.7%, respectively. The multivariate analysis indicated that maternal orphans (AOR 0.31, 95% CI 0.12–0.80), paternal orphans (AOR 0.35, 95% CI 0.14–0.89), and non-orphans (AOR 0.45, 95% CI 0.21–0.99) were less likely to be non-adherent compared to double orphans. Double orphans who had a sibling as a caregiver were more likely to be non-adherent. The first mean CD4 count prior to initiating treatment was 520, 601, 599, and 844 (cells/ml), respectively (p<0.001). Their mean age at sero-status detection was 5.9, 5.3, 4.8, and 3.9 (year old), respectively (p<0.001).ConclusionsDouble orphans were at highest risk of ART non-adherence and especially those who had a sibling as a caregiver had high risk. They were also in danger of initiating ART at an older age and at a later stage of HIV/AIDS compared with other orphan categories. Double orphans need more attention to the promote child’s adherence to ART.

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Antiretroviral Therapy Adherence Did Not Differ between Thai Children with Biological and Those with Nonbiological Parents

Cited by 10 publications

References 4 publications

Association of Antiretroviral and Clinic Adherence With Orphan Status Among HIV-Infected Children in Western Kenya

Association of Antiretroviral and Clinic Adherence With Orphan Status Among HIV-Infected Children in Western Kenya

Adherence to antiretroviral therapy and its correlates among HIV-infected children at an HIV clinic in New Delhi

High Risk of ART Non-Adherence and Delay of ART Initiation among HIV Positive Double Orphans in Kigali, Rwanda

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