Antisecretory effects of Librax in patients with duodenal ulcer

Head, Henry B.; Hammond, James M.

doi:10.1007/bf02233067

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Librax is a drug consisting of chlordiazepoxide 5 mg and clidinium bromide 2.5 mg and used to treat peptic ulcers, spastic colon, and gastritis. It helps to relieve stomach spasms, abdominal cramps, and anxiety related to gastric disorders [11,12]. Chlordiazepoxide is the first benzodiazepine to be synthesised [13].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

Eskander

Abdrabou²,

Ahmed

2013

Ind J Clin Biochem

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Hormones play an important role in the digestive system. The main hormones that control digestion are gastrin, secretin, and cholecystokinin. Herein, the current study is concerned with assessing the effect of spasmo canulase and librax drugs on the human hormones profile. Blood samples were withdrawn from adult patients to measure serum FSH, E2, LH, prolactin, progesterone, DHEAS, testosterone, TSH, T3, T4, fasting insulin, and cortisol. All hormone concentrations were determined quantitatively using ELISA procedure. Intriguingly, the present study showed putative changes including thyroid and sex hormonal profiles. Eventually, we concluded that the prospective study could be important in drug dose optimization and providing new medical guidelines to avoid side effects that could harm patients.

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Section: Introductionmentioning

confidence: 99%

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

Eskander

Abdrabou²,

Ahmed

2013

Ind J Clin Biochem

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“…Recently the combination of benzodiazepines and atropine-like drugs has been introduced in the treatment of gastric ulcer and related disorders (Head & Hammond, 1968). This paper deals with the effect of such combinations on the behaviour of mice.…”

Section: Introductionmentioning

confidence: 99%

The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice

Ahtee

Shillito

1970

British J Pharmacology

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Summary Male albino mice were watched in red light on a tunnel board to test exploration and their motor activity was assessed in an open cage, 30 min after intraperitoneal injection of drugs. Atropine and methylatropine 5 or 10 mg/kg did not alter the motor activity of the mice, while chlordiazepoxide 25 or 50 mg/kg and diazepam 10 or 20 mg/kg increased the activity, especially at the lower of the two doses used. All the compounds used except methylatropine adversely affected the exploratory behaviour. When atropine 10 mg/kg was given with the benzodiazepines, the activity of the mice was reduced and exploratory behaviour was further impaired. Methylatropine did not have this effect.

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Librax® (Roche)

Tallarida

1982

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Antisecretory effects of Librax in patients with duodenal ulcer

Cited by 3 publications

References 9 publications

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice

Librax® (Roche)

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