Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review

Doobay, Minakshi; Sharma, Verinder; Eccles, Heidi

doi:10.1080/14737175.2022.2117614

Cited by 4 publications

(3 citation statements)

References 61 publications

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“…Fourteen ASMs were found to be associated with the occurrence of MDs, with lamotrigine, levetiracetam and carbamazepine exhibiting multiple significant MDs. The presence of certain positive MDs, such as tremor, titubation and parkinsonism, aligns with the findings of a retrospective analysis 28 . However, it is worth noting that certain positive ASM‐related MDs, such as paralysis and hemiplegia, have not been previously reported.…”

Section: Discussionsupporting

confidence: 84%

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Movement disorders associated with antiseizure medications: A real‐world disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System

Zhou

Wei

Chen

et al. 2023

Brit J Clinical Pharma

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AimsPatients with epilepsy often require long‐term use of antiseizure medications (ASMs) to control their seizures. However, movement disorders (MDs) related to ASMs can significantly impact their quality of life. This study aims to analyse MDs related to ASMs in the Food and Drug Administration Adverse Event Reporting System database to provide recommendations for safe medication.MethodsAll adverse drug reactions associated with 26 marketed ASMs in Food and Drug Administration Adverse Event Reporting System were extracted for analysis. Disproportionality analyses were used to assess the association between ASMs and MDs, and signal colour scale maps were created to identify potential ASM–MD safety signals.ResultsA total of 1921 cases experienced MDs while taking ASMs were included. A higher prevalence of MDs was observed in females compared to males. The association between specific MDs with ASMs was revealed, including known and unknown MDs such as tremors, Parkinson and paralysis. Lamotrigine and carbamazepine exhibited multiple significant MDs, while levetiracetam and pregabalin were linked to the earlier onset of MDs. Generally, higher doses were linked to a higher incidence of MDs.ConclusionMDs were the most obvious adverse drug reactions in the nervous system triggered by using ASMs. Fourteen drugs exhibited positive signals for MDs, including some not previously reported. Conversely, 12 ASMs were deemed to have a lower possibility of inducing MDs. The incidence of MDs can be mitigated by selecting appropriate ASMs for epileptic patients. These findings enhance our understanding of the relationship between ASMs and MDs.

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Section: Discussionsupporting

confidence: 84%

“…The presence of certain positive MDs, such as tremor, titubation and parkinsonism, aligns with the findings of a retrospective analysis. 28…”

Section: Disproportionality Analyses Of Hlt and Pt Levelmentioning

confidence: 99%

Movement disorders associated with antiseizure medications: A real‐world disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System

Zhou

Wei

Chen

et al. 2023

Brit J Clinical Pharma

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“…As obsessões são pensamentos intrusivos e indesejados que causam ansiedade, enquanto as compulsões são comportamentos repetitivos realizados para aliviar a ansiedade causada pelas obsessões (Stein, 2002). Além disso, estudos recentes sugerem que o TOC pode estar associado a outros transtornos neuropsiquiátricos, como o transtorno do tique (Doobay, Sharma, Eccles, 2022). Isso sugere que o TOC pode ser parte de um espectro mais amplo de transtornos neuropsiquiátricos.…”

Section: Resultsunclassified

Transtorno Obsessivo Compulsivo (Toc) Em Crianças E Adolescentes: Uma Revisão Integrativa De Literatura

Dos Santos

2023

Rev. Contemp.

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O Transtorno Obsessivo Compulsivo (TOC) é uma condição psiquiátrica que afeta crianças e adolescentes e tem ganhado crescente atenção nos últimos anos. Esta revisão integrativa de literatura examinou aspectos essenciais relacionados ao TOC nessa faixa etária, incluindo sua etiologia, sintomas, diagnóstico e tratamento, ressaltando a importância de uma avaliação cuidadosa para um diagnóstico preciso e a escolha de intervenções terapêuticas apropriadas. Além disso, a possível relação entre o sistema imunológico e o a doença foi investigada, sugerindo que alterações na função imunológica podem desempenhar um papel significativo na patogênese do transtorno, abrindo caminho para futuras pesquisas e tratamentos. O TOC foi abordado como uma condição complexa que demanda uma abordagem terapêutica personalizada devido à sua heterogeneidade e etiologia multifatorial. Além disso, a conscientização pública sobre o distúrbio e a capacitação de profissionais de saúde foram apontadas como fundamentais para enfrentar os desafios clínicos relacionados ao diagnóstico e tratamento. Em resumo, esta revisão contribui para o avanço do conhecimento sobre o TOC em crianças e adolescentes, destacando sua complexidade e a necessidade contínua de pesquisa para aprimorar a compreensão da doença e desenvolver abordagens terapêuticas mais eficazes. A integração entre a neurobiologia e o tratamento é fundamental para melhorar os resultados clínicos e a qualidade de vida dos afetados por essa condição desafiadora.

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Longitudinal Comparison of PNES spell and ASM reduction in PNES Patients with and without Epilepsy Discharged from an Epilepsy Monitoring Unit

Yaraki,

Yu,

AlKhateeb

et al. 2024

Epilepsy Research

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Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review

Cited by 4 publications

References 61 publications

Movement disorders associated with antiseizure medications: A real‐world disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System

Movement disorders associated with antiseizure medications: A real‐world disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System

Transtorno Obsessivo Compulsivo (Toc) Em Crianças E Adolescentes: Uma Revisão Integrativa De Literatura

Longitudinal Comparison of PNES spell and ASM reduction in PNES Patients with and without Epilepsy Discharged from an Epilepsy Monitoring Unit

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