2020
DOI: 10.1212/wnl.0000000000010993
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Antiseizure medication use during pregnancy and risk of ASD and ADHD in children

Abstract: ObjectiveTo determine whether children born to women who use anti-seizure medications (ASMs) during pregnancy have higher risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) independent of confounding factors.MethodsWe used Swedish-register data (n = 14,614 children born 1996–2011 and followed through 2013) to examine associations in children of women with epilepsy, using the largest sample to date and adjusting for a range of measured confounders. We examined maternal-re… Show more

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Cited by 43 publications
(41 citation statements)
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“…Veroniki et al [25], although confirming the data on VPA, also provide evidence that prenatal LTG and OXC may also produce an increased occurrence of ASD. Noteworthily, a similar risk associated with prenatal VPA was also reported for ADHD [54]. Out of 580 VPA children, 4.8% developed ADHD and they had a 48% elevated risk of ADHD in comparison to children unexposed to VPA [85].…”
Section: Neurodevelopmental Riskssupporting
confidence: 56%
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“…Veroniki et al [25], although confirming the data on VPA, also provide evidence that prenatal LTG and OXC may also produce an increased occurrence of ASD. Noteworthily, a similar risk associated with prenatal VPA was also reported for ADHD [54]. Out of 580 VPA children, 4.8% developed ADHD and they had a 48% elevated risk of ADHD in comparison to children unexposed to VPA [85].…”
Section: Neurodevelopmental Riskssupporting
confidence: 56%
“…It should be particularly underlined that the children of mothers using VPA during pregnancy were also found to display a higher incidence of autism spectrum dis-orders (ASD) and attention-deficit hyperactivity disorder (ADHD) symptoms (see below) [2,[52][53][54].…”
Section: Effects Of Aeds Use In Pregnant Women On Their Children's Co...mentioning
confidence: 99%
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“…The higher likelihood of receiving lamotrigine might be due to the following. 1) Lamotrigine monotherapy during pregnancy does not increase the risk of birth defects and other diseases, including autism spectrum disorder and attention-deficit/hyperactivity disorder [ 25 , 26 ], though it is difficult to adjust the dose during pregnancy. 2) Lamotrigine monotherapy has few effects on the reproductive endocrine system [ 27 , 28 ].…”
Section: Discussionmentioning
confidence: 99%