Antisense <i>HEMA1</i> RNA Expression Inhibits Heme and Chlorophyll Biosynthesis in Arabidopsis

Kumar, Ankit; Söll, Dieter

doi:10.1104/pp.122.1.49

Cited by 121 publications

(83 citation statements)

References 39 publications

(38 reference statements)

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“…The expression of HEMA1 is light-regulated and is predominant in photosynthetic tissues in Arabidopsis (Ilag et al 1994) and other plants (Bougri and Grimm 1996;Tanaka et al 1996;Tanaka et al 1997). Since antisense HEMA1 Arabidopsis plants showed decreased levels of Chl, noncovalently-bound heme, and ALA; HEMA1 is considered to play the major role in tetrapyrrole biosynthesis (Kumar and Soll 2000). On the other hand, HEMA2 is preferentially expressed in nonphotosynthetic tissues and its expression is not altered by illumination (Kumar et al 1996).…”

Section: Glu-trna Reductasementioning

confidence: 99%

Tetrapyrrole Metabolism inArabidopsis thaliana

Tanaka

Kobayashi²,

Masuda

2011

The Arabidopsis Book

226

232

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This manuscript is dedicated to Prof. Mamoru Mimuro of Kyoto University who passed away in Februay 2011.Higher plants produce four classes of tetrapyrroles, namely, chlorophyll (Chl), heme, siroheme, and phytochromobilin. In plants, tetrapyrroles play essential roles in a wide range of biological activities including photosynthesis, respiration and the assimilation of nitrogen/sulfur. All four classes of tetrapyrroles are derived from a common biosynthetic pathway that resides in the plastid. In this article, we present an overview of tetrapyrrole metabolism in Arabidopsis and other higher plants, and we describe all identified enzymatic steps involved in this metabolism. We also summarize recent findings on Chl biosynthesis and Chl breakdown. Recent advances in this field, in particular those on the genetic and biochemical analyses of novel enzymes, prompted us to redraw the tetrapyrrole metabolic pathways. In addition, we also summarize our current understanding on the regulatory mechanisms governing tetrapyrrole metabolism. The interactions of tetrapyrrole biosynthesis and other cellular processes including the plastid-to-nucleus signal transduction are discussed.

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Section: Glu-trna Reductasementioning

confidence: 99%

Tetrapyrrole Metabolism inArabidopsis thaliana

Tanaka

Kobayashi²,

Masuda

2011

The Arabidopsis Book

226

232

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“…HEMA1 is known to encode the first committed enzyme of the chlorophyll biosynthesis pathway of higher land plants (Fig. 6A) (51)(52)(53), whereas genomes uncoupled 4/5 (GUN4/GUN5) are known to determine the branch pathways leading to Pchlide/chlorophyll synthesis (54)(55)(56). As a result of chlorophyll synthesis occurring in the dark, a pool of Pchlide accumulates in the etioplasts.…”

Section: Pif3 Acts Downstream Of Ein3/eil1 To Prevent Light-inducedmentioning

confidence: 99%

Ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth

Zhong

Shi

Xue

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

153

151

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Significance Seedlings’ ability to both adapt to their soil environment and acquire photoautotrophic capacity under various buried conditions is a life-or-death issue for terrestrial flowering plants. By designing and utilizing a standardized real-soil assay, we identify the key features of germinating seedlings’ soil response and deduce that the gaseous phytohormone ethylene acts as the primary regulator of soil-induced plant morphogenetic changes. Moreover, our study illustrates that an EIN3/EIL1-conducted PIF3–ERF1 molecular circuitry enables seedlings to synchronize the rate of protochlorophyllide biosynthesis with upward growth, a mechanism critical to the prevention of photooxidative damage during seedlings’ initial transition from dark to light in natural conditions.

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“…The leaf color mutants have been reported in many high plants such as rice (1), tomato (2) and Arabidopsis thaliana (3). Up to now, most of the mutants were controlled by the nucleus genes (4,5), however, there are few reports on plant albinism controlled by cytogene.…”

Section: Introductionmentioning

confidence: 99%

Proteome analysis of chloroplast proteins in stage albinism line of winter wheat (triticum aestivum) FA85

Hou¹,

Xu²,

Du³

et al. 2009

BMB Reports

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The "stage albinism line of winter wheat" FA85 was a specific natural mutant strain on leaf color. This physiological mutation was controlled by cytogene. In order to reveal the genetic and biochemical mechanism of albinism, 2-DE was used to investigate the difference of chloroplast protein expression pattern between FA85 and its parent wheat Aibian 1. From the results of 2-DE gels analysis, approximately 683 spots were detected on each gel, and 57 spots were expressed differently at least two-fold. Using MALDI-TOF/TOF MS, 14 of 57 spots were identified, which could be categorized into four classes: carbon metabolism, energy metabolism, defense/stress response and signal transduction. Compared with the parent wheat, the expression of ATPase-γ and GP1-α was up-regulated in FA85, and of other proteins was down-regulated. Together, we concluded that the expression of chloroplast proteins had changed obviously in FA85, which might be related to the leaf color mutant. [BMB reports 2009; 42(7): 450-455]

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Antisense HEMA1 RNA Expression Inhibits Heme and Chlorophyll Biosynthesis in Arabidopsis

Cited by 121 publications

References 39 publications

Tetrapyrrole Metabolism inArabidopsis thaliana

Tetrapyrrole Metabolism inArabidopsis thaliana

Ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth

Proteome analysis of chloroplast proteins in stage albinism line of winter wheat (triticum aestivum) FA85

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