Antisense Oligonucleotide Delivery with Polyhexylcyanoacrylate Nanoparticles as Carriers

Zimmer, Andreas

doi:10.1006/meth.1999.0786

Cited by 49 publications

(13 citation statements)

References 29 publications

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“…Aqueous acidic médium DEAE dextran -Vero cells, mouse Protection from degradation, significantly enhanced cellular uptake, improved antisense treatments for tumour and antiviral therapy, liver targeting [114] *Pharmacological availability/bioavailability determined based on the extent of hypoglycaemic/hypocalcemic response relative to subcutaneous injection of insulin or salmon calcitonin, respectively. [117] PEG-/PS80-…”

Section: Odnsmentioning

confidence: 99%

Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?

Graf

McDowell

Rades

2009

Expert Opinion on Drug Delivery

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The properties inherent in poly(alkylcyanoacrylate) (PACA) nanoparticles, such as biocompatibility and biodegradability of the polymer, a simple preparation process and particularly the entrapment of bioactives, specifically proteins and peptides, have sparked extensive interest in these nanoparticles as drug delivery systems. Research has focused on the oral route of administration, however ocular, transdermal and delivery across the blood-brain barrier have also been investigated. Despite numerous promising studies, no formulation with this colloidal carrier has been marketed to date. A number of factors have been identified as interfering with the reproducibility of in vitro and in vivo results, which impedes the comparison of the plethora of experiments done with PACA nanoparticles. This review will highlight the challenges and opportunities of using PACA nanoparticles as drug delivery systems, including polymerisation mechanisms and templates, entrapment, release, nanoparticle uptake and toxicity. In vitro and in vivo studies, as well as possible surface modifications for targeted delivery in the human field and veterinary applications of PACA nanoparticles are reviewed. Emphasis will be placed on microemulsions as templates for the preparation of PACA nanoparticles and oral delivery of proteins and peptides.

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Section: Odnsmentioning

confidence: 99%

Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?

Graf

McDowell

Rades

2009

Expert Opinion on Drug Delivery

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“…The most common treatments for cancer are a) surgery, b) chemotherapy, c) radiation therapy, and d) targeted therapy. antisense therapeutic research [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Currently, over a hundred oligonucleotides are in clinical trials from 30 different pharmaceutical companies [23].…”

Section: Editorialmentioning

confidence: 99%

Antisense Cancer Therapy: Do Antisense Oligonucleotides Hold Promise as a Cure for Cancer?

Mohammad¹

2017

Chem Sci J

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“…In vivo, the biodistribution of the oligonucleotide nanoparticle complex resulted in targeting of oligonucleotides to the liver. Improvements in antisense treatments with nanoparticles were demonstrated for tumor therapy as well as for antiviral applications (Zimmer, 1999). Sineerat et al (2008) investigated a water insoluble complex of cationic propranolol HCl with anionic sodium lauryl sulfate.…”

Section: Miscellaneousmentioning

confidence: 99%

Ion-paired Drug Delivery: An Avenue for Bioavailability Improvement

Suresh¹,

Paul²

2011

Sierra Leone j. biomed. res.

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Ion-pairing is reported to improve the lipophilicity and subsequently the transport rate of polar drugs across lipid membranes. Lipophilisation of ionic drugs with high aqueous solubilities by ion-pair formation with appropriate counter-ion have proven to be promising for several applications. The aim of this review is to present the usefulness of ion-pair for improving the poor bioavailability of ionic drugs through various routes. The review covers an update on the applications of this strategy to improve drug delivery through various routes of administration including ocular, oral, parenteral and transdermal. It is discussed how ion-pair complexes assist in introducing functionality that would allow formation of a neutral molecule which can be subsequently encapsulated into delivery systems to be distributed by various routes of administration.

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Antisense Oligonucleotide Delivery with Polyhexylcyanoacrylate Nanoparticles as Carriers

Cited by 49 publications

References 29 publications

Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?

Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?

Antisense Cancer Therapy: Do Antisense Oligonucleotides Hold Promise as a Cure for Cancer?

Ion-paired Drug Delivery: An Avenue for Bioavailability Improvement

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