2000
DOI: 10.1016/s0304-3940(00)01524-x
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Antisense oligonucleotide suppression of Na+/Ca2+ exchanger activity in primary neurons from rat brain

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Cited by 21 publications
(10 citation statements)
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“…Analysis with fura-2 following brief glutamate activation demonstrated a rise in intracellular calcium that did not differ between the two groups. Recovery of intracellular calcium to baseline levels was significantly delayed in the NCX2 knockout mice, a finding consistent with Ranciat-McComb et al 36 This suggests that NCX2 is involved in the recovery to baseline of intracellular calcium following glutamate-induced depolarisation in hippocampal pyramidal cells. As noted above, Jeon et al 49 has also demonstrated larger focal infarcts in these animals following MCA occlusion.…”
Section: Transgenic Animal Studiessupporting
confidence: 87%
See 1 more Smart Citation
“…Analysis with fura-2 following brief glutamate activation demonstrated a rise in intracellular calcium that did not differ between the two groups. Recovery of intracellular calcium to baseline levels was significantly delayed in the NCX2 knockout mice, a finding consistent with Ranciat-McComb et al 36 This suggests that NCX2 is involved in the recovery to baseline of intracellular calcium following glutamate-induced depolarisation in hippocampal pyramidal cells. As noted above, Jeon et al 49 has also demonstrated larger focal infarcts in these animals following MCA occlusion.…”
Section: Transgenic Animal Studiessupporting
confidence: 87%
“…Antisense oligonucleotides against a conserved sequence of all three NCX isoforms resulted in higher baseline cytosolic calcium levels and a slower return to baseline following activation of calcium influx by NMDA. 36 These findings taken together, suggest that in depolarised and glucopenic cells NCX operates in calcium entry mode as predominately sodium extrusion occurs. As the energy state of the cell improves, and/or reperfusion occurs, the NCX operates in a protective rectifying calcium exit mode.…”
Section: Excitotoxicity Studiesmentioning
confidence: 90%
“…Although PMCAs have higher affinity to Ca 2ϩ than do NCXs, the much lower turnover rate of PMCAs may cause quick saturation at elevated levels of Ca 2ϩ (10). The limited capacity of PMCAs suggests a more prominent role for NCXs in the process of rapid Ca 2ϩ extrusion; indeed, NCXs drive Ca 2ϩ extrusion after synaptic stimulation (11,12). In addition to the turnover rate, the capacity of a transporter molecule is determined by its density on the plasma membrane.…”
mentioning
confidence: 99%
“…Under ischemic conditions, NCX3-deficient mice exhibit increased neuronal damage [13, 23]. Studies also showed that NCX plays a major role in restoring baseline Ca 2+ levels following glutamate-induced depolarization in cortical and hippocampal neurons [11, 24]. These findings highlight NCX function in the regulation of Na + and Ca 2+ following synaptic activity.…”
Section: Introductionmentioning
confidence: 99%