Antisense Oligonucleotides

Crooke, Stanley T.

doi:10.1007/978-1-59259-717-8_15

Cited by 5 publications

(1 citation statement)

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“…This category includes bacterial, viral, and fungal diseases, as well as certain types of cancer. The basis of this approach is the “antisense method” for controlling gene expression (protein synthesis). − The antisense method is a naturally occurring gene regulation mechanism that relies upon the ability of messenger RNA, which is a single-stranded nucleic acid, to be recognized in a gene-specific manner by complementary nucleic acid molecules. This recognition occurs by the familiar and highly reliable Watson−Crick base pairing that is responsible for the specificity of the genetic code.…”

Section: A Medicinal Motivationmentioning

confidence: 99%

Inorganic Mimics of Ribonucleases and Ribozymes: From Random Cleavage to Sequence-Specific Chemistry to Catalytic Antisense Drugs

1998

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ContentsI. Introduction 939 A. Medicinal Motivation 941 B. Tools for Probing Ribozyme Mechanisms 943 C. Tools for Molecular Biology 943 II. The Chemistry of RNA Cleavage 943 A. Catalysts and Their Mechanisms 943 B. Assays for RNA Cleavage 944 1. Models for RNA (Both Good and Bad) 944 2. Dimeric Assays 946 3. Polymeric Assays 947 4. Chimeric Assays 948 III. Sequence-Specific Nucleophilic RNA Cleavage 949 A. Key Design Features 949 B. Preparation and Behavior of Sequence-Specific RNA Cleavage Agents 950 1. Hybrid Enzymes 950 2. Ribozyme Mimics Based on Metal Complexes 951 3. Ribozyme Mimics Based on Organic Catalysts 954 IV. Recent Ideas for the Design of Ribozyme Mimics 955 A. Creating RNA Bulges and Loops 955 B. Minimal Nucleotide Replacement 955 V. Comparison of Systems 956 VI. Concluding Remarks 957 VII. Acknowledgments 957 VIII. References 958

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