Antisocial personality disorder, conduct disorder, and substance abuse in schizophrenia.

Mueser, Kim T.; Drake, Robert E.; Ackerson, Theimann H.; Alterman, Arthur I.; Miles, Keith M.; Noordsy, Douglas L.

doi:10.1037/0021-843x.106.3.473

Cited by 77 publications

(46 citation statements)

References 18 publications

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“…In light of the findings that schizophrenia alone is associated with increased risks of physical aggression 12,15,26 and violent crime, 26 the present findings, if replicated, further circumscribe the type of aggressive behavior engaged in by men with schizophrenia. Many studies have shown an increased prevalence of physical aggression and violent crime by men with schizophrenia and any PD, 15 with antisocial PD, [26][27][28][29] with conduct disorder before 15 years of age, 30,31 and with SUDs. 32,33 Findings from the present study concur and extend previous findings by showing that schizophrenia plus a PD or an SUD was associated with an increased risk of any sexual offense and of physically aggressive sexual offenses.…”

Section: Commentmentioning

confidence: 99%

Psychotic Disorders and Sex Offending in a Danish Birth Cohort

Alden

Brennan²,

Hodgins

et al. 2007

Arch Gen Psychiatry

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Context: Psychotic disorders are associated with an increased risk of aggressive behavior and violent crime. Whether there is also an association with sex offending is unknown.Objectives: To estimate the lifetime prevalence of arrests for sexual offenses (with and without physical aggression) among men and women with psychotic disorders, the moderating effects of comorbid personality disorders and substance use disorders, and the prevalence rates for 4 specific psychotic disorders. Design:We examined official records of arrests for sexual offenses with and without physical aggression to compare persons hospitalized with a psychotic disorder with those who had never been hospitalized. Results: Among the men, 2.2% were hospitalized with psychotic disorders. These men committed 8.4% of the physicallyaggressivesexualoffensesand9.0%ofthenon-physically aggressive sexual offenses of the men in the cohort. Compared with men who had never been hospitalized, men with psychotic disorders without a personality disorder or a substance use disorder were not at increased risk of arrest for physically aggressive sexual offenses but were 3 times more likely to have been arrested for non-physically aggressive sexual offenses. Psychotic disorders with comorbid personality disorders or substance use disorders were associated with a 6-fold increased risk of physically aggressive sex offending and a 3-to 5-fold increased risk of non-physically aggressive sex offending.Conclusions: Psychotic disorders comorbid with personality disorders and substance use disorders are associated withanincreasedriskofsexoffendingwithandwithoutphysical aggression. Mental health policy and practice need to take account of these findings to improve functional outcome among persons with psychotic disorders.

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Section: Commentmentioning

confidence: 99%

Psychotic Disorders and Sex Offending in a Danish Birth Cohort

Alden

Brennan²,

Hodgins

et al. 2007

Arch Gen Psychiatry

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“…3,[7][8][9] Although research on the effects of cannabis abuse on clinical parameters in individuals with schizophrenia has produced conflicting results, two prospective studies attempting to examine the longer-term outcome of cannabis use in this illness have both demonstrated poorer outcome and increased intensity of positive symptoms. 10,11 A number of prospective epidemiological studies also now provide support for the hypothesis that cannabis abuse increases the subsequent risk for developing schizophrenia.…”

mentioning

confidence: 99%

Cannabis use and abuse correlates in a homogenous South African schizophrenia population

2009

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Objective. Worldwide, cannabis is the most widely used illicit substance, and it has been identified as a correlate in schizophrenia samples for poorer symptomatic and functional outcomes in many international studies. The object of this retrospective study was to identify the prevalence of cannabis use/abuse and the demographic and clinical correlates therefor in a large homogeneous South African schizophrenia population.Methods. As part of a large genetic study, 547 subjects with a diagnosis of schizophrenia were recruited. Demographic and clinical data were collected and each participant underwent a urinary drug screen. Use/abuse of cannabis was defined as using cannabis more than 21 times in a single year. Subjects with and without cannabis use/abuse were statistically compared. Results. Significant differences between the two groups were found in terms of gender, marital status, age of onset of schizophrenia, number of hospitalisations and relapses, alcohol abuse, smoking, the Scale for the Assessment of Positive Symptoms (SAPS) scores for hallucinations, delusions, bizarre behaviour and formal thought disorder, and the Scale for the Assessment of Negative Symptoms (SANS) score for avolition/apathy. Conclusion. The prevalence of cannabis use/abuse in this study was high, and our findings were comparable with those of previous international studies. Abuse/use started mainly in the teenage years, was more prevalent among males than females, and was associated with negative overall outcomes. There was also a positive correlation between cannabis and nicotine and alcohol use/abuse. Determination of cannabis abuse based solely on history was found to be reliable, and urine cannabis testing appeared to be of limited value in routine management of this group of schizophrenic patients.

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“…Pour Fulwiler et Ruthazer [26], ce serait plus la précocité de l'abus de substances indépendamment des troubles des conduites que l'abus de substances concomitant qui serait liée à la violence des personnes présentant une pathologie mentale. Or, la précocité de l'abus de substances pourrait dépendre de la présence d'une personnalité antisociale [66]. Indépendamment d'une pathologie mentale, abus d'alcool et personnalité antisociale auraient des similitudes étiogéniques, génétiques et environnementales [60].…”

Section: Importance Chronologiqueunclassified

Schizophrénie et violence : comorbidités et typologies

Vandamme

2009

Annales Médico-psychologiques, revue psychiatrique

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Antisocial personality disorder, conduct disorder, and substance abuse in schizophrenia.

Cited by 77 publications

References 18 publications

Psychotic Disorders and Sex Offending in a Danish Birth Cohort

Psychotic Disorders and Sex Offending in a Danish Birth Cohort

Cannabis use and abuse correlates in a homogenous South African schizophrenia population

Schizophrénie et violence : comorbidités et typologies

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