Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats

Sousa, Albertina Antonielly Sydney de; Soares, Pedro Marcos Gomes; Almeida, Arisa Nara Saldanha de; Maia, Alana Rufino; Souza, Emmanuel Prata de; Assreuy, Ana Maria Sampaio

doi:10.1016/j.jep.2010.05.012

Cited by 57 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They exhibit a diverse array of pharmacological properties such as antispasmodic (de Sousa et al, 2010), antioxidant (Yang et al, 2010), antimicrobial (Reichling et al, 2009), antiplasmid (Schelz et al, 2006) anti-inflammatory and anticancer activities, and, being natural compounds, represent a class of growing interest (McKay & Blumberg, 2006;Bakkali et al, 2008). They exhibit a diverse array of pharmacological properties such as antispasmodic (de Sousa et al, 2010), antioxidant (Yang et al, 2010), antimicrobial (Reichling et al, 2009), antiplasmid (Schelz et al, 2006) anti-inflammatory and anticancer activities, and, being natural compounds, represent a class of growing interest (McKay & Blumberg, 2006;Bakkali et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Mentha piperitaessential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

et al. 2014

View full text Add to dashboard Cite

Mentha piperita (MP), also known as peppermint, is an aromatic and medicinal plant widely used in the food industry, perfumery and cosmetic, pharmacy and traditional medicine. Its essential oil (EO) displays antimicrobial activity against a range of bacteria and fungi. In this study, we found that MP EO lethal cytotoxicity is associated with increased levels of intracellular reactive oxygen species, mitochondrial fragmentation and chromatin condensation, without loss of the plasma membrane integrity, indicative of an apoptotic process. Overexpression of cytosolic catalase and superoxide dismutases reverted the lethal effects of the EO and of its major component menthol. Conversely, deficiency in Sod1p (cytosolic copper-zinc-superoxide dismutase) greatly increased sensitivity to both agents, but deficiency in Sod2p (mitochondrial manganese superoxide dismutase) only induced sensitivity under respiratory growth conditions. Mentha piperita EO increased the frequency of respiratory deficient mutants indicative of damage to the mitochondrial genome, although increase in mitochondrial thiol oxidation does not seem to be involved in the EO toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Mentha piperitaessential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In fact, the epithelium capacity to provide factors to relax the smooth muscle is firmly established. These factors include nitric oxide (NO), carbon monoxide, PGE 2 and prostacyclin, which protect the airway from excessive bronchoconstriction (Barnes 1998, de Sousa et al 2010, Billington et al 2013, Vieira et al 2013. We tested several inhibitors to identify which factors produced by epithelial cells could be involved in the antispasmogenic activity of glucagon in vitro.…”

Section: Discussionmentioning

confidence: 99%

Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E2

Insuela¹,

Daleprane²,

Coelho³

et al. 2015

Journal of Endocrinology

View full text Add to dashboard Cite

Glucagon is a hyperglycemic pancreatic hormone that has been shown to provide a beneficial effect against asthmatic bronchospasm. We investigated the role of this hormone on airway smooth muscle contraction and lung inflammation using both in vitro and in vivo approaches. The action of glucagon on mouse cholinergic tracheal contraction was studied in a conventional organ bath system, and its effect on airway obstruction was also investigated using the whole-body pletysmographic technique in mice. We also tested the effect of glucagon on lipopolysaccharide (LPS)-induced airway hyperreactivity (AHR) and inflammation. The expression of glucagon receptor (GcgR), CREB, phospho-CREB, nitric oxide synthase (NOS)-3, pNOS-3 and cyclooxygenase (COX)-1 was evaluated by western blot, while prostaglandin E 2 (PGE 2 ) and tumour necrosis factor-a were quantified by enzyme-linked immunoassay and ELISA respectively. Glucagon partially inhibited carbacholinduced tracheal contraction in a mechanism clearly sensitive to des-His1-[Glu9]-glucagon amide, a GcgR antagonist. Remarkably, GcgR was more expressed in the lung and trachea with intact epithelium than in the epithelium-denuded trachea. In addition, the glucagon-mediated impairment of carbachol-induced contraction was prevented by either removing epithelial cells or blocking NOS (L-NAME), COX (indomethacin) or COX-1 (SC-560). In contrast, inhibitors of either heme oxygenase or COX-2 were inactive. Intranasal instillation of glucagon inhibited methacholine-induced airway obstruction by a mechanism sensitive to pretreatment with L-NAME, indomethacin and SC-560. Glucagon induced CREB and NOS-3 phosphorylation and increased PGE 2 levels in the lung tissue without altering COX-1 expression. Glucagon also inhibited LPS-induced AHR and bronchoalveolar inflammation. These findings suggest that glucagon possesses airway-relaxing properties that are mediated by epithelium-NOS-3-NO-and COX-1-PGE 2 -dependent mechanisms.

show abstract

“…Though patients were not assessed for abdominal discomfort in this study, the M. balsamea Willd extract which contains peppermint oil would be expected to help manage this symptom that typically accompanies bloating and constipation in IBS patients [22,45] . Peppermint oil has also been shown to act as an antispasmodic attenuating contractile responses to acetylcholine, histamine, 5-hydroxytryptamine, and substance P [46] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Quebracho, Conker Tree, and M. balsamea Willd Blended Extract in a Randomized Study in Patients with Irritable Bowel Syndrome with Constipation

Brown¹,

Scott-Hoy²,

Jennings

2015

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

bloating, and total constipation plus bloating scores for the herbal extract and placebo groups. The repeated measures analysis of variance tests showed a significant time/group interaction for the herbal extract effect on improving all three scores. There were significant improvements in the average constipation (p=0.0034), bloating (p<0.001) and constipation plus bloating scores (p<0.001) for the herbal extracts group compared to no improvement for the placebo arm. There were no reports of AEs over the 2-week period. CONCLUSION:The results from this pilot study suggest a blended extract of Quebracho, Conker Tree and M. balsamea Willd can safely manage symptoms in IBS-C subjects. MATERIALS AND METHODS:This was a 2-week doubleblind, randomized, placebo-controlled study of patients previously diagnosed with IBS-C (N=16). Subjects were randomized at baseline and assessed using a scoring system for symptoms of constipation, bloating, and a total constipation plus bloating score before receiving the blended herbal extract or placebo. At baseline and 2 weeks, vital signs, concomitant medications, diary entries of symptoms, and adverse events were recorded as well as assessment of constipation, bloating, and a total constipation plus bloating score. Treatment group, time of symptom scores, and the interaction between group and time were analyzed. Paired t-tests were used to assess temporal effects within each treatment group. RESULTS: There were no baseline differences in the constipation,

show abstract

Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats

Abstract: Peppermint oil exhibited antispasmodic activity on rat trachea involving prostaglandins and nitric oxide synthase.

Cited by 57 publications

References 21 publications

Mentha piperitaessential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

Mentha piperitaessential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E2

Efficacy of a Quebracho, Conker Tree, and M. balsamea Willd Blended Extract in a Randomized Study in Patients with Irritable Bowel Syndrome with Constipation

Contact Info

Product

Resources

About