Antispasmodic effect ofAcorus calamus Linn. is mediated through calcium channel blockade

Gilani, Anwarul Hassan; Shah, Abdul Jabbar; Ahmad, Manzoor; Shaheen, Farzana

doi:10.1002/ptr.2000

Cited by 86 publications

(42 citation statements)

References 19 publications

(16 reference statements)

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“…In addition, HESc displaced the cumulative concentration-response curves of CaCl 2 to the right, in a non-parallel manner and the maximal response was reduced, in a concentration-dependent manner, by 15.4; 56.3 and 92.1%, respectively (Figure 5), suggesting that the antispasmodic effect is possibly mediated through the inhibition of Ca 2+ influx probably through of Ca V . Other studies show that antispasmodic constituents present in various medicinal plants mediate their effect generally by blocking the calcium channel (Ghayur et al, 2006;Gilani et al, 2006;Shah et al, 2010). Similar results of inhibition of contractile responses to calcium were found in previous studies with the hydroalcoholic extract of S. cumini by our laboratory in preparation of vascular arteries rings isolated from normotensive and spontaneously hypertensive rats.…”

Section: Resultssupporting

confidence: 85%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (E max ), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (E max 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl 2 -induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle.

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Section: Resultssupporting

confidence: 85%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

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“…The contraction of smooth muscle induced by high K + is dependent, in turn, upon the entry of Ca 2+ into the cells through voltage activated ion channels, while inhibition of high K + -induced contraction results from the prevention of Ca 2+ entry through these channels (Al-Zuhair et al, 1996;Bolton, 1979), a characteristic of calcium channel blockers (CCB). It was observed previously that the antispasmodic constituents present in various medicinal plants mediate their effect usually through a CCB action (Ghayur et al, 2006;Gilani et al, 2006;Shah et al, 2010). In order to elucidate the possible mechanism of the antispasmodic effect of CF, we investigated the interference of CF with voltage operated calcium channels.…”

Section: Resultsmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The antispasmodic activity of Jatropha gossypiifolia L., Euphorbiaceae, aerial parts was investigated in rodents using the mouse intestinal transit model and acetylcholine (ACh, to 10 -4 M) and calcium (CaCl 2 , 10 -4 to 10 -1 M)-induced contractions of isolated rat jejunum. Similar to atropine (1 mg/kg), oral doses of ethanolic extract (EE) of J. gossypiifolia (500, 1000 and 2000 mg/kg) produced a decrease in intestinal transit (37.6 to 57.1%) when compared with control. The ACh-induced contraction in the jejunum was inhibited by EE (0.5, 1.0 and 2.0 mg/ mL), chloroformic (CF) and aqueous fractions (0.1 and 0.5 mg/mL) and methanolic subfraction (0.05 and 0.25 mg/mL), suggesting an antimuscarinic mechanism. CaCl 2 -induced responses in jejunum were also attenuated in the presence of CF (0.05 and 0.1 mg/mL) implying a direct interference of CF with the influx of calcium ions in the cells. Only the organic fraction of the extract had a calcium-antagonist effect, whereas both chloroformic and aqueous fractions had anticholinergic effect. These results suggest that the antispasmodic effect of J. gossypiifolia may be due a combination of anticholinergic and calcium antagonist mechanisms.

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“…Another study by Gilani et al (2006) determined its possible pharmacological basis as an antispasmodic and antidiarrheal. In the isolated rabbit jejunum preparation, the crude extract of AC caused inhibition of spontaneous and high K þ (80 mM)-induced contractions, with respective EC 50 values of 0.42 AE 0.06 and 0.13 AE 0.04 mg=mL (mean AE SEM; n ¼ 6 to 8), thus showing spasmolytic activity, mediated possibly through calcium channel blockade (CCB).…”

Section: Antispasmodic Activitymentioning

confidence: 99%

Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

Mukherjee

Venkatesan

Mal

et al. 2007

Pharmaceutical Biology

112

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Acorus calamus Linn. (Araceae), commonly known as ''sweet flag'' or ''calamus'', is a semiaquatic, perennial, aromatic herb with creeping rhizomes. The plant is found in the northern temperate and subtropical regions of Asia, North America, and Europe. The plant exhibits polyploidy. Many ethnomedicinal and ethnobotanical uses have been ascribed to the rhizomes of the plant. A. calamus Linn. (AC) has been used as traditional Chinese and Indian prescriptions for its beneficial effects on memory disorder, learning performance, lipid peroxide content, and anti-aging and anticholinergic activity. Moreover, pharmacological studies have revealed that Acorus rhizome and its constituents, particularly a-and b-asarone, possess a wide range of pharmacological activities such as sedative, CNS depressant, behavior modifying, anticonvulsant, acetylcholinesterase inhibitory, memory enhancing, anti-inflammatory, antioxidant, antispasmodic, cardiovascular, hypolipidemic, immunosuppressive, cytoprotective, antidiarrheal, antimicrobial, anthelmintic, insecticidal, adulticidal, diuretic, antioxidant, genotoxic, and mutagenic activities. This review is an effort to explore the different phytoconstituents and pharmacological activities of Acorus calamus.

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Antispasmodic effect ofAcorus calamus Linn. is mediated through calcium channel blockade

Cited by 86 publications

References 19 publications

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

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