Antisperm Antibodies: Etiology, Pathogenesis, Diagnosis, and Treatment

Mazumdar, Setu; Levine, Adam Seth

doi:10.1016/s0022-5347(05)69029-5

Cited by 27 publications

(43 citation statements)

References 86 publications

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“…Olgun sperm oluşumu 72 günlük sikluslar halinde pubertede başlar, yaşam boyunca sürer. Germ hücrelerinin çeşitli aşamalardan geçtikten sonra sperm hücresi haline gelmesi "spermatogenez" olarak adlandırılır 5 . Bu süreç içinde germ hücreleri mayoz bölünme sonrası 46 kromozomlu diploid halden 23 kromozomlu haploid hale gelirler ve yine 23 kromozom içeren haploid yumurta hücresi ile birleşerek yine 46 kromozomlu yeni bir bireyin oluşmasına olanak sağlarlar.…”

Section: Spermatogenezunclassified

“…Bu süreç içinde germ hücreleri mayoz bölünme sonrası 46 kromozomlu diploid halden 23 kromozomlu haploid hale gelirler ve yine 23 kromozom içeren haploid yumurta hücresi ile birleşerek yine 46 kromozomlu yeni bir bireyin oluşmasına olanak sağlarlar. Spermatogenez proliferasyon fazı, redüksiyon-bölünme fazı ve farklılaşma fazı olmak üzere üç aşamada incelenir [4][5][6] .…”

Section: Spermatogenezunclassified

“…Seminifer tübüller testis hacminin yaklaşık %80-90'ını oluştururlar. Bu nedenle testis hacmi kabaca sperm üretim potansiyeli hakkında fikir verir [4][5][6] . Seminiferöz epitelde iki farklı tip hücre bulunur.…”

Section: Spermatogenezunclassified

“…Mitoz bölünme ile oluşan bu hücrelerin bir bölümü spermatogenezis sürecine girerken bir kısmı dejenere olur , [4][5][6] .…”

Section: Proliferasyon Fazıunclassified

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Sperm Değerlendirmesi

Satar¹,

Gençdal²

2014

Arşiv Kaynak Tarama Dergisi

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Infertility may be defined as failure to meet the reproductive function. Statistically infertility affects 15% of married couples at reproductive age. In 30-40% of cases males and 40-50% of cases females are responsible for infertility. The first step in diagnosis of male infertility is semen analysis. Semen analysis is the most important examination in the evaluation of male fertility. This review includes up to date information about the semen analysis in which the World Health Organization is trying to provide international standardization work. Key words: Infertility, semen, spermatogenesis, sperm analysis. ÖZETİnfertilite, üreme fonksiyonunun yerine getirilememesi olarak tanımlanabilir. İstatistiksel olarak üreme çağındaki evli çiftlerin %15'ini etkileyen bir sorundur. Çiftlerin %30-40'ında erkek, %40-50'sinde ise kadın infertiliteden sorumludur. Erkek infertilitesinde tanıda ilk basamak spermiyogram tetkikidir. Semen analizi erkeğin fertilite değerlendirmesinde en önemli tetkiktir. Bu yazıda Dünya Sağlık Örgütünün uluslararası standardizasyonu sağlamaya çalıştığı semen analizi konusunda güncel bilgiler gözden geçirilmiştir Anahtar sözcükler: İnfertilite, semen, spermatogenez, spermiyogram.

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Section: Spermatogenezunclassified

“…Mitoz bölünme ile oluşan bu hücrelerin bir bölümü spermatogenezis sürecine girerken bir kısmı dejenere olur , [4][5][6] .…”

Section: Proliferasyon Fazıunclassified

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Sperm Değerlendirmesi

Satar¹,

Gençdal²

2014

Arşiv Kaynak Tarama Dergisi

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“…Since vaginal and cervical tissues have an active and sensitive mucosal immune system, the active local immunoregulatory mechanisms in the female reproductive tract have an effect on fertility. This explains the local reactions leading to an inflammation and the high level of serum antisemen antibodies in infertile women [3,4].…”

Section: Introductionmentioning

confidence: 99%

Immunodominant semen proteins I: New patterns of sperm proteins related to female immune infertility

et al. 2013

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Infertility affects approximately 10% of couples at reproductive age. Semen constituents may be potential immunogenic structures for women. The aim of our work is to detect and identify sperm proteins interacting with serum IgG antibodies from women with fertility disorders. The biochemical characterization of sperm antigens was performed using one and two dimensional gel electrophoresis, both of which were followed by immunoblotting. The IgG-binding proteins of interest were identified using mass spectrometry. From the serum pool of 30 infertile women, we detected sperm antigens within a relative molecular mass range between 30–80 kDa with an isoelectric point of 4–7. No antigens were detected using the serum pool from 10 fertile women (control group). Heat shock proteins (HSP 70) were identified as major sperm antigens associated with female immune infertility. Additionally, we report for the first time that alpha-enolase is a significant sperm antigen from the serum pool of infertile women. We suggest that the IgG-binding proteins identified in our study are related to immune infertility in the case of certain women with abnormally high levels of IgG antibodies linked to sperm proteins. Our results might be useful in the diagnoses of female immune infertility and may provide potential targets for further therapeutic treatment.

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Semen analysis in laboratory practice: An overview of routine tests

Andrade-Rocha¹

2003

Clinical Laboratory Analysis

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Semen analysis is a basic step in the investigation of several disturbances affecting the male genital tract. Analysis of seminal parameters provides important clinical information on the spermatogenesis and functional competence of spermatozoa, as well as on the secretory pattern of the accessory genital glands. Semen analysis is particularly useful in the evaluation of couples requiring fertility investigation (to detect genital infections and pathologies) and in verifying the influence of environmental factors, drugs, lifestyle, chemical products, and professional activities on several diseases affecting male reproductive health. Measure of semen quality is of substantial interest for diagnoses in clinical urology, andrology, and gynecology. Currently, basic requirements for semen analysis are standardized by World Health Organization (WHO) guidelines that describe several procedures for an objective evaluation of the semen quality with diagnostic purposes. These guidelines include: parameters for the physical and biochemical evaluation of semen; parameters for the analysis of sperm characteristics; and other seminal parameters that can be easily adopted in any laboratory. This report summarizes current concepts on semen analysis and the significance of the seminal parameters for reaching a diagnosis based on the procedures recommended by WHO guidelines.

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Antisperm Antibodies: Etiology, Pathogenesis, Diagnosis, and Treatment

Cited by 27 publications

References 86 publications

Sperm Değerlendirmesi

Sperm Değerlendirmesi

Immunodominant semen proteins I: New patterns of sperm proteins related to female immune infertility

Semen analysis in laboratory practice: An overview of routine tests

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