Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats

Naseem, Mulla Zehera; Patil, Srinivas Reddy; Patil, Somnath; Ravindra,; Patil, Saraswati B.

doi:10.1016/s0378-8741(98)00006-3

Cited by 58 publications

(32 citation statements)

References 8 publications

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“…All three extracts demonstrated prevailing antispermatogenic activity, the most potent being ethanol extract. Again the effects on the male rats were assessed by measuring the testicular weights and biochemical assay (Naseem et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

et al. 2011

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SUMMARY:Ubiquitous consumption of Momordica charantia is hinged on credence of its potency in alleviating ailments. Almost no data exist on its quantitative relationship to the testes. The aim was to study the histomorphometric effect of Momordica charantia seed extract (MC), ascorbic acid (C), alpha-tocopherol (E) and testosterone (T) on the testes of rats. Ninety five mature 6-8 week-old male Sprague-Dawley (S-D) rats allotted randomly into six groups. Group I: fed MC for 16 weeks. Group II: administered MC for 8 weeks, later distilled water for another 8 weeks. Group III: administered C, E, T and a combination of all three test solutions (CET) for 8 weeks and later fed MC for another 8 weeks. Group IV: received MC initially for 8 weeks and later administered C, E, T and CET for another 8 weeks. Group V: fed concurrently the extract, C, E, T and CET for 8 weeks. Group VI (control): administered C, E, T, CET and distilled water for 16 weeks. The doses for MC, C, E and T were 50 mg/100 g b.w/oral/day, 0.01, 20.0 and 0.05 mg/kg. The animals were sacrificed; testes estimated for volume. Diameter, cross sectional area (AC), number of profiles per unit area (NA), length density (LV) and numerical density (NV) of the seminiferous tubules determined. The mean testicular volumes, tubular diameters and AC showed significant decline (p ≤ 0.05) in Groups I and III compared to controls. On cessation of MC values recovered to baseline control value. Groups IV and V, were not significantly (p ≤ 0.05) different from controls. There was a significant (p ≤ 0.05) increase in NA, LV and NV of seminiferous tubules in Groups I and III compared to controls. Histomorphometric data supports a reversible deleterious effect of MC on testes.

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Section: Introductionmentioning

confidence: 99%

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

et al. 2011

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“…1,[29][30][31][32][33][34][35] The medicinal value of the cactus, Opuntia, is widely known in many parts of the world and several studies have reported the nutraceutical value, hepatoprotective properties and anti-inflammatory potential in experimental studies. 11,21,36 The medicinal properties of Opuntia have been attributed to a variety of phytochemicals present in the cladode and fruits.…”

Section: Discussionmentioning

confidence: 99%

Reversible antifertility effect of <i>Opuntia elatior</i> Mill. fruit extract

Shivabasavaiah

Shivanandappa

2015

Int J Reprod Contracept Obstet Gynecol

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“…The observations related to the unique nature of the change in the seminiferous tubules are similar as in every plant assayed so far in male anti-fertility perspective. Viz., Carica papaya (Lohiya and Goyal, 1992); Euphorbia nerrifolia (Mali and Chaturvedi, 1994); Azadirachta indica (Kasturi et al, 1997); Momordica charantia (Naseem et al, 1998); Coculus pendulus (Verma and Lall, 1999); methanol stem extract of Sarcostemma acidum (Roxb) Voigt (Verma et al, 2002); stem extract of Tinospora cordifolia (Willd) (Gupta and Sharma, 2003); ethanol extract of Semecarpus anacardium ; and saponins isolated from Albizia lebbeck bark (Gupta et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Reversible histoarchitecture study of testis and cauda epididymis and changes in cauda epididymal epithelial cell types on treatment with benzene extract of Ocimum sanctum leaves in albino rats

Ahmed¹,

Ahamed²,

Aladakatti³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYIn the present study, an attempt has been made to assess whether the effect of benzene extract of Ocimum sanctum leaves on the ultrastructural changes in the epithelial cells of the cauda epididymis, its subsequent recovery in the seminiferous epithelium and fertility of male albino rats. Wistar strain male albino rats were orally administered benzene extract of 250 mg/kg body weight of O. sanctum leaves followed by subsequent recovery maintaining suitable controls for 48 days. Results indicate decrease in the weights of testis, epididymis and seminal vesicles. Other accessory organs were not affected. Total count, cell and nuclei diameters of germ cells and Leydig cells were reduced. Cauda epididymis exhibited significant reduction in epithelial height and nuclei diameter of epithelial cells. Cells showed vacuolization with exhibit of signs of degeneration. Ultra study revealed that, in general, the cauda epididymis was affected and in particular, the principal, clear and basal cells were highly disturbed. Further, there was decrease in the size of lipid droplets, mitochondria, Golgi complex, endoplasmic reticulum and accumulation of lysosomal bodies. Fertility performance test showed no implantation in female rats mated with O. sanctum treated rats. Moreover, their recovery after withdrawal of treatment was observed suggesting that the effect of the treatment is transient and reversible. A recovery period resulted in normal spermatogenesis and fertility, suggesting reversible antispermatogenic and antifertility effects of the plant.

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Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats

Cited by 58 publications

References 8 publications

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

Reversible antifertility effect of <i>Opuntia elatior</i> Mill. fruit extract

Reversible histoarchitecture study of testis and cauda epididymis and changes in cauda epididymal epithelial cell types on treatment with benzene extract of Ocimum sanctum leaves in albino rats

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Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats

Cited by 58 publications

References 8 publications

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

Reversible antifertility effect of &lt;i&gt;Opuntia elatior&lt;/i&gt; Mill. fruit extract

Reversible histoarchitecture study of testis and cauda epididymis and changes in cauda epididymal epithelial cell types on treatment with benzene extract of Ocimum sanctum leaves in albino rats

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Reversible antifertility effect of <i>Opuntia elatior</i> Mill. fruit extract