Antistreptolysintiter und Krankheitsimmunit�t bei Scharlach

Wiesener, H; Stück, Burghard

doi:10.1007/bf01467123

Cited by 9 publications

(2 citation statements)

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“…In infectious diseases, antibiotics are administered. It has been suggested that an immediate therapy with antibiotics which eliminates microorganisms might decrease the supply of antigen for macrophages, and this in turn would make a rapid functioning of the body's own defense mechanisms less effective (9,19,22). Since in those parts of the body which have poor blood circulation, chemotherapy sometimes results only in subinhibitory levels of antibiotics (20), it is of clinical importance to know what can happen to microorganisms in vivo which have not been reached by a full effective dosage of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dihydrostreptomycin on Phagocytosis of Mouse-Peritoneal Macrophages In Vitro

Adam¹,

Staber²,

Belohradsky³

et al. 1972

Infect Immun

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The effect of the antibiotic dihydrostreptomycin on the phagocytic and bactericidal ability of peritoneal macrophages obtained from mice has been investigated. In subliminal concentrations which did not influence the bacterial growth, the drug caused macrophages to ingest and kill bacteria ( Escherichia coli ) at a higher rate than did macrophages without antibiotic. The differences for phagocytosis and intracellular killing of E. coli with and without a subliminal amount of dihydrostreptomycin were statistically significant. Macrophages pretreated with the antibiotic did not demonstrate any enhancement of phagocytosis.

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Section: Discussionmentioning

confidence: 99%

“…The question of whether antibiotics influence cellular immunity in any way arises when chemotherapeutics are administered. Using antibiotics has sometimes been considered disadvantageous for the organism to produce a high level of antibodies since killing of bacteria by antibiotics would not leave sufficient antigenic material for the macrophages (9,19,22).…”

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confidence: 99%