Antistricture Ureteral Stents with a Braided Composite Structure and Surface Modification with Antistenosis Drugs
Lirong Duan,
Lu Li,
Zeyu Zhao
et al.
Abstract:The present work describes the development of a drug-loaded ureteral stent with antistricture function based on a trilayer design in which the middle layer was braided from biodegradable poly(p-dioxanone) (PDO) monofilament. Antistenosis drugs rapamycin and paclitaxel were loaded into a silk fibroin (SF) solution and coated on the inner and outer layers of the braided PDO stent. The cumulative release of rapamycin and paclitaxel was sustained over 30 days, with a total release above 80%. The drug-loaded ureter… Show more
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