Antithrombin Activity of Fucoidan

Church, Frank C.; Meade, J. B.; Treanor, Rita E.; Whinna, Herbert C.

doi:10.1016/s0021-9258(18)94111-6

Cited by 156 publications

(3 citation statements)

References 32 publications

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“…The results suggest that it inhibit the intrinsic or common coagulation pathway in sulphated polysaccharides and does not inhibit the extrinsic coagulation pathway in anticoagulant activity. In the coagulation cascade, the targeted proteins allows the interaction of sulphation of pattern in an anticoagulation property (Church et al, 1989). The anticoagulant activity results shown by these crude SPS is in good correlation with the metachromasia effect and sulphate to sugar molar ratio.…”

Section: The Anticoagulation Activity Of Crude Sps Of Sargassum Tenerrimum Sargassum Wightii Turbinaria Conoides Turbinaria Ornata and Pamentioning

confidence: 86%

Anticoagulant Properties from Marine Algae – A Systemic Review

Pandian

Srinivasan

2021

ijrps

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The anticoagulants are used to eliminate mainly blood clots. They are offered to patients who are at risk of developing clots, in order to improve their general wellbeing. Anticoagulant namely heparin, has many disadvantages like thrombocytopenia, antithrombin defensives, bleeding disorders and etc. The marine algae are sulphated polysaccharides has many advantages from commercially available anticoagulant which is derived from the animal's sources. The anticoagulant is found in various species of marine algae, mainly from the red, brown and green algae and its determined by various methods, namely APTT, PT, TT, CT. The marine algae species are Padina tetrastromatica, Ulva fasciata, Corallina, Asparagopsis taxiformis, Grateloupia filicina, Ulva rigida, Bursatella leachii, Agardhiella subulate, Turbinaria ornate, Monostroma angicava, Arthrospira platensis, Sargassum tenerrimum, Sargassum wightii, Turbinaria conoides, Lomentaria catenate, Gracilaria debilis, and Monostroma nitidum are some of the species revealed its anticoagulant properties. The anticoagulant produced by the marine species are compared with standard namely heparin by in vitro and in vivo methods and the review result reveal that the anticoagulant values produced are nearer to the standard and in some species, the value are more than that of standard. The sample are crude extracted one and some samples are isolated from different fraction.

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Section: The Anticoagulation Activity Of Crude Sps Of Sargassum Tenerrimum Sargassum Wightii Turbinaria Conoides Turbinaria Ornata and Pamentioning

confidence: 86%

Anticoagulant Properties from Marine Algae – A Systemic Review

Pandian

Srinivasan

2021

ijrps

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“…NpCF demonstrated better control of fucoidan release than NpCF 1% in PBS (pH 7.4), with successful increasing of cumulative mass in release medium over 72 h, 79.7%±1.2% of total fucoidan release. This behavior would be favorable to overcome procoagulant disorders, since soluble fucoidan in plasma act on heparin cofactor II and antithrombin [12,13].…”

Section: Development and Characterization Of Nanoparticulate Systemsmentioning

confidence: 99%

“…The discovery of anticoagulant polysaccharides from marine organisms, specially sulfated fucans, and their incorporation in advanced formulations may represent a new option for the treatment and prophylaxis of procoagulant disorders [10]. Known as fucoidan (FC), sulfated fucans found in brown algae (Fucus vesiculosus) [11] can inhibit thrombin by antithrombin or heparin cofactor II [12,13]. Compared to other sulfated polysaccharides, sulfated fucans are widely available from various sources at low cost and related to different biological activities [14,15] such as anticoagulant/antithrombotic [16][17][18][19], antiviral [20][21][22], immunomodulatory [23], antiinflammatory [24,25], antiangiogenic [26][27][28][29], antitumoral [26,30,31] and antimetastatic [30,32,33].…”

Section: Introductionmentioning

confidence: 99%

A promising oral fucoidan-based antithrombotic nanosystem: development, activity and safety

et al. 2018

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Fucoidan-loaded nanoparticles emerge as great candidates to oral anticoagulant therapy, due to increasing of bioavailability and circulation time of this natural anticoagulant. Crosslink between chitosan chains are performed using glutaraldehyde to confer higher gastric pH resistance to nanoparticle matrices. In this work, chitosan-fucoidan nanoparticles, without (NpCF) and with glutaraldehyde crosslink (NpCF 1% and NpCF 2%), were prepared to evaluate their anticoagulant, antithrombotic and hemorrhagic profile. Nanoparticles were characterized by average diameter, polydispersity index, zeta potential, Fourier transform infrared spectroscopy and fucoidan in vitro release. Anticoagulant and antithrombotic activities were determined by in vitro and in vivo models, respectively. Hemorrhagic profile was in vivo evaluated by tail bleeding assay. Preparations showed nanometric and homogeneous average diameters. Zeta potentials of NpCF and NpCF 1% were stable over gastrointestinal pH range, which was confirmed by low fucoidan release in gastric and enteric media. In pH 7.4, NpCF and NpCF 1% demonstrated fucoidan release of 65.5% and 60.6%, respectively, within the first 24 hours. In comparison to fucoidan, NpCF and NpCF 1% showed increased in vitro anticoagulant activity. A significant difference on oral antithrombotic profile of NpCF 1% was found in comparison to fucoidan. Bleeding profile of NpCF and NpCF 1% showed no differences to control group, indicating the safety of these systems. Surprisingly, oral antithrombotic profile of commercially available fucoidan, from Fucus vesiculosus, has not been previously determined, which reveals new possibilities. In this work, significant advances were observed in anticoagulant and antithrombotic profiles of fucoidan through the preparation of NpCF 1%.

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Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: A review

Logeart-Avramoglou

Jozefonvicz

1999

J. Biomed. Mater. Res.

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The functionalized dextrans termed carboxymethyl benzylamide sulfonate dextran (CMDBS) represent a family encompassing a wide range of polymers. These soluble macromolecular compounds, which are substituted with specific chemical functional groups, are designed to interact with living systems. By analogy with glycosaminoglycan heparin, a natural highly charged anionic polysaccharide that exerts a variety of biological effects, we postulated that CMDBS compounds also possess binding sites capable of specific interactions with biological constituents, depending on the overall composition of the polymer. The synthesis and heparin-like properties of these CMDBS have been extensively investigated. Thus, it appears that dextran derivatives can mimic the action of heparin in regard to its interactions with antithrombin and serine proteases involved in blood coagulation. Other derivatives interact with various components of the immune system or with adhesive proteins such as fibronectin in modulating the proliferation of Staphylococcus aureus. Because they are able to stimulate wound healing in various in vivo models, these polysaccharides may also constitute a family of tissue repair agents because of their protecting and potentiating effects with heparin binding growth factors. Moreover, dextran derivatives in contact with cells such as endothelial cells, smooth muscle cells, or tumoral cells can affect both cell proliferation and metabolism. It appears that these bioactive polymers are also efficient tools to investigate the precise mechanism of action of individual biological activities by contrasting their mode of action to that of heparin. In addition to their numerous biological properties and biospecificity, functionalized dextrans are relatively simple to manufacture and exempt of donor contaminant, which make them attractive in a variety of clinical applications.

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Antithrombin Activity of Fucoidan

Cited by 156 publications

References 32 publications

Anticoagulant Properties from Marine Algae – A Systemic Review

Anticoagulant Properties from Marine Algae – A Systemic Review

A promising oral fucoidan-based antithrombotic nanosystem: development, activity and safety

Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: A review

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