Antithrombin III activity and platelet count are more likely to decrease in twin pregnancies than in singleton pregnancies

Tsunoda, Tetsuo; Ohkuchi, Akihide; Izumi, Akio; Watanabe, Takashi; Matsubara, Shigeki; Sato, Ikuo; Minakami, Hisanori

doi:10.1034/j.1600-0412.2002.810907.x

Cited by 41 publications

(58 citation statements)

References 23 publications

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“…Pregnancy is associated with increased platelet production and enhanced platelet destruction based on the following observations: platelet distribution width increases with advancing gestation [11,14] and MPV versus platelet count shows a significant inverse relationship in pregnancy [14]; some pregnant women exhibit a gradual decline in platelet count in late pregnancy, especially in pregnancy complicated with HDP [23,24]; platelet lifespan is shortened in pregnancy, especially in pregnancy complicated with HDP [25];…”

Section: Discussionmentioning

confidence: 99%

Platelet aggregation in citrated whole blood of the first trimester of pregnancy

Umazume

Yamada

Morikawa

et al. 2015

Clinica Chimica Acta

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It was recently suggested that platelet reactivity is reduced in early pregnancy. This study was performed to determine whether the citrated whole blood from 33 pregnant women in first trimester showed spontaneous platelet aggregation and whether it differed in extent from that of 11 non-pregnant women. Platelet count and number of platelet aggregates (PA) were serially determined in the same citrated whole blood specimens at 15, 30, 45, 60, 75, and 90 minutes after blood sampling using a hematology analyzer. The number of PA increased significantly at 30 minutes and thereafter in both groups, but was consistently lower for pregnant than non-pregnant women over the 90-minute observation period. The platelet count decreased significantly in a time-dependent manner in both groups, but was significantly lower at 30 and 90 minutes for non-pregnant than pregnant women. The number of PA showed a significant positive correlation with net decrease in platelet count for both pregnant and non-pregnant women. PA counts were also significantly positively correlated with mean platelet volume. In conclusion, platelet reactivity monitored by the increase in number of PA and the fall in platelet count was reduced in early pregnancy compared with non-pregnant healthy controls. (194 words) Key words: mean platelet volume, platelet reactivity, pregnancy, spontaneous platelet aggregation, venous thromboembolism Highlights  Extent of spontaneous platelet aggregation (SPA) was examined. Pregnant women in first trimester were compared with healthy controls. The SPA was less likely to occur in pregnant women. Fall in platelet count was greater in healthy controls. Thus, platelet reactivity was reduced in early pregnancy.

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Section: Discussionmentioning

confidence: 99%

Platelet aggregation in citrated whole blood of the first trimester of pregnancy

Umazume

Yamada

Morikawa

et al. 2015

Clinica Chimica Acta

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“…Asymptomatic thrombocytopenia is reported in 5 % of normal pregnancy at preterm, whereas about 15 % of pregnant women develop severe thrombocytopenia if they develop preeclampsia during the last term [5]. Thrombocytopenia occurs more and slightly severer in twin pregnancy than in singleton pregnancy [7].…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in Hypertensive Disease of Pregnancy

Habas

Rayani

Ganterie

2012

J Obstet Gynecol India

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Background Thrombocytopenia is defined as a platelet count of less than 150 9 10 3 ll. It is commonly diagnosed and has attracted more interest from the researchers in pregnant women during the last 20 years, especially in hypertensive pregnant women. Aim To assess the incidence of thrombocytopenia in hypertensive pregnant women during the third trimester of pregnancy. Methods Five hundred forty-four pregnant women were included in this study from a total of 10,272 admitted at the Obstetrics and Gynecology Department at Tripoli Medical Center during January-August 2007. Frequent blood pressure monitorings and full blood counts were performed in several medical follow ups. They were not known to be HBV, HCV, or HIV positive women before pregnancy, and none was reported to have evidence of HBV, HCV, or HIV upon performing HBs-Ag, anti-HCV antibody, or HIV-antigen positive tests. Data were arranged in Excel Microsoft program version 2010, and statistically analyzed by SPSS windows program version 17. Results Five hundred and forty-four women were hypertensive according to WHO hypertension definition criteria. Sixty-seven women had only one reading of high blood pressure, while 39 women fulfilled HELP syndrome criteria (hemolysis elevated liver enzymes low platelet). These 39 women were excluded from the study. Therefore, only 438 pregnant women remained eligible for the study. The mean age was (32.56 ± 1.5), with their ages ranging between 18 and 49 years. Most of the included women were primigravida 179 (39 %), gravid 2, para one were 72 (16.4 %), and the rest were gravid 3 or more (42.6 %). The blood pressure was 140-160/90-110 mmHg in 365 women (83.4 %), and 73 women (16.7 %) had blood pressure readings more than 160/110 mmHg. Mean platelets count was (206.49 9 10 3 /ll ± 3.35), and ranged between (41.0 -449.0 9 10 3 /ll). Thrombocytopenia (less than 150 9 10 3 /ll) was recorded in 103 women (23.5 %). All pregnancy cases were delivered safely with no fetal complications. Conclusion Gestational thrombocytopenia (GT) is recognized as a major cause of thrombocytopenia particularly in hypertensive pregnant women during the third trimester. Careful follow up during and after pregnancy for those women is recommended.Habas E.

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“…Some women develop a gradual decline in antithrombin (AT) activity during the late stage of pregnancy, even in the absence of hypertension [12,13,25]. This decline in AT activity continues until the day of or one day after delivery, and a prompt normalization of AT activity occurs postpartum in such patients with pregnancy-induced AT deficiency (PIATD) [13].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Eclampsia Other Than Hypertension: Pregnancy-Induced Antithrombin Deficiency and Extraordinary Weight Gain

Yamada

Kuwata

Matsuda

et al. 2011

Hypertension in Pregnancy

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Antithrombin III activity and platelet count are more likely to decrease in twin pregnancies than in singleton pregnancies

Abstract: Antithrombin III activity and platelet count show a greater decrease in twin than in singleton pregnancies, perhaps due to a greater increase in thrombin generation.

Cited by 41 publications

References 23 publications

Platelet aggregation in citrated whole blood of the first trimester of pregnancy

Platelet aggregation in citrated whole blood of the first trimester of pregnancy

Thrombocytopenia in Hypertensive Disease of Pregnancy

Risk Factors of Eclampsia Other Than Hypertension: Pregnancy-Induced Antithrombin Deficiency and Extraordinary Weight Gain

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