2002
DOI: 10.1182/blood.v99.11.4015
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Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells

Abstract: The serpin antithrombin III (AT III), the most important natural inhibitor of thrombin activity, has been shown to exert marked anti-inflammatory properties and proven to be efficacious in experimental models of sepsis, septic shock, and disseminated intravascular coagulation. Moreover, clinical observations suggest a possible therapeutic role for AT III in septic disorders. The molecular mechanism, however, by which AT III attenuates inflammatory events is not yet entirely understood. We show here that AT III… Show more

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Cited by 154 publications
(120 citation statements)
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“…11,12 In contrast to these reports, AT has been demonstrated to inhibit leukocyte activation directly. [13][14][15] These observations suggest that anti-inflammatory effects of AT may be mediated mainly by its direct inhibitory properties on leukocyte activation.…”
Section: Introductionmentioning
confidence: 93%
“…11,12 In contrast to these reports, AT has been demonstrated to inhibit leukocyte activation directly. [13][14][15] These observations suggest that anti-inflammatory effects of AT may be mediated mainly by its direct inhibitory properties on leukocyte activation.…”
Section: Introductionmentioning
confidence: 93%
“…Furthermore, antithrombin was capable in delaying microvascular thrombus formation in a murine model (21,22). Beside its anticoagulatory actions, antithrombin reveals anti-inflammatory activities in a variety of experimental models, which are independent of its direct influence on the coagulatory cascade (7,23). Beneficial effects of antithrombin could also be shown in patients with severe sepsis (24), which, however, have not been confirmed in the multinational KyberSept trial (25).…”
Section: Discussionmentioning
confidence: 99%
“…Antithrombin III, a plasma-derived serine protease inhibitor, controls the activity of thrombin and other proteases of the coagulation cascade (4,5). Furthermore, antithrombin has previously shown a large number of anti-inflammatory actions, independent of its anticoagulatory effects (6)(7)(8). It is supposed that antithrombin interacts with endothelial cells, thus inhibiting leukocyteendothelial cell interaction.…”
mentioning
confidence: 99%
“…Indeed, AT, via interaction with HSPG present on endothelial cells or on neutrophils, promotes the release of antiinflammatory prostacyclin and blocks the activation of the proinflammatory NF-B, thereby decreasing platelet and neutrophil activation, chemotaxis, and interaction with the endothelium, 38 -41 effects that are lost after chemically blocking the heparin-binding domain of AT. 39,40 No thrombotic phenotype was observed so far in mice with altered heparan-sulfate (HS) moieties or deficiencies in the HSPG core proteins. 3-O-sulfation of the pentasaccharide core sequence of heparin/heparan-sulfate is essential for interaction with AT.…”
Section: Discussionmentioning
confidence: 99%