Antithrombin levels are associated with the risk of first and recurrent arterial thromboembolism at a young age

Loon, Janine E. van; Dippel, Diederik W.J.; Maat, Moniek P.M. de; Leebeek, Frank W.G.

doi:10.1016/j.atherosclerosis.2018.01.014

Cited by 7 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AT deficiency appears to be associated with a modestly increased risk of arterial thrombosis ( 66 , 67 ). Further, low plasma levels of AT were found to be associated with a significantly increased risk of arterial thrombotic events ( 68 ). Additional studies are warranted to determine the effect of AT deficiency on risk of arterial thrombosis.…”

Section: Antithrombinmentioning

confidence: 99%

Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis

Grover

Mackman

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A number of endogenous anticoagulant proteins, such as antithrombin and heparin cofactor II, are members of the serine protease inhibitor (SERPIN) family. These SERPIN anticoagulants function by forming irreversible inhibitory complexes with target coagulation proteases. Mutations in SERPIN family members, such as antithrombin, can cause hereditary thrombophilias. In addition, low plasma levels of SERPINs have been associated with an increased risk of thrombosis. Here, we review the biological activities of the different anticoagulant SERPINs. We further consider the clinical consequences of SERPIN deficiencies and insights gained from preclinical disease models. Finally, we discuss the potential utility of engineered SERPINs as novel therapies for the treatment of thrombotic pathologies.

show abstract

Section: Antithrombinmentioning

confidence: 99%