Antithrombogenicity of fluorinated diamond-like carbon films

Saito, Toshiya; Hasebe, Terumitsu; Yohena, Satoshi; Matsuoka, Yoshiaki; Kamijo, Aki; Takahashi, Koki; Suzuki, Tetsuya

doi:10.1016/j.diamond.2004.09.017

Cited by 117 publications

(83 citation statements)

References 17 publications

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“…We previously reported that an a-C:H:F film with sufficient C-F bonds on its surface showed excellent antithrombotic properties owing to its hydrophobicity. (16,17) This spectrum led us to expect the improvement of antithrombotic properties, because it is characteristic of an antithrombotic a-C:H:F film.…”

Section: Discussionmentioning

confidence: 99%

“…(14,15) We previously showed that fluorine doping in a-C:H films contributes to a reduction of blood cell adhesion and adsorption of plasma protein. (16,17) We also reported that a-C:H:F-coated biomaterials can play a nontoxic mediating role in vivo, (18) and we developed fluorine-incorporated a-C:H (a-C:H:F) coating techniques for vascular interventional devices using radio frequency plasma-enhanced chemical vapor deposition (RF-PECVD). (19) However, the adhesion of leukocytes in relation to a-C:H:F has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fluorine-Incorporated Amorphous Carbon Coating Inhibits Adhesion of Blood Cells to Biomaterials

Horikawa

Maegawa²,

Hasebe

et al. 2017

Sensors and Materials

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluorine-Incorporated Amorphous Carbon Coating Inhibits Adhesion of Blood Cells to Biomaterials

Horikawa

Maegawa²,

Hasebe

et al. 2017

Sensors and Materials

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“…Researches have been conducted to address this shortcoming; one method is to modify the membrane's surface. Recently, paryelene film and fluorinated-diamond-like-carbon (F-DLC) have become well known as two of the best coating materials for medical tools, due to their outstanding blood compatibility and conformal coating properties (Noh et al, 2004;Saito et al, 2005). However, such conformal coating characteristics can also become a problem if these materials are directly deposited on the membrane surface.…”

mentioning

confidence: 99%

Review of Surface Modification of Nanoporous Polyethersulfone Membrane as a Dialysis Membrane

Prihandana¹,

Sriani²,

Mahardika³

2015

IJTech

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Nanoporous polyethersulfone (PES) membrane is widely used as a filtration membrane in hemodialysis systems. Unfortunately, it has low blood compatibility, and induces blood clots that adhere to the membrane's surface during dialysis treatment. This paper reports on a review of surface modification that is used to improve the PES membrane's blood compatibility. The method consists of applying two coating materials, in the form of parylene and fluorinated diamond-like carbon (F-DLC) films, onto the membrane's surface. The parylene film is deposited on the diffusion layer of the membrane surface using glycerin liquid, while the F-DLC film is specially coated on the supporting layer of the membrane. The unique property of parylene, which has the characteristics of conformal coating, prevents the parylene from being coated on the supporting layer of the membrane. Conversely, F-DLC film, which is hard, fragile and has a less conformal coating than parylene, is only meant to be coated on the supporting layer. Finally, the coated membranes, along with the bare PES membrane, are compared and investigated under a long-term diffusion test to assess their permeability and blood compatibility. The experiment results show that both coating materials have the capacity to improve the membrane's blood compatibility in different ways.

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“…Nevertheless, the cytotoxicity of DLC materials is very low with no in vitro effects on mouse macrophages, human fibroblasts, monocytes, osteoblasts [20,21] even under in vivo conditions in subcutaneous, bone and muscle tissue in guinea pig [22], sheep and rat models [23]). Doping DLC films with fluorine is favorable and results in antithrombotic effects and the suppression of platelet activation [24]. N or Si doping improves the endothelium cell growth and provides antithrombotic effects [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

et al. 2013

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Protective ultra-thin barrier films gather increasing economic interest for controlling permeation and diffusion from the biological surrounding in implanted sensor and electronic devices in future medicine. Thus, the aim of this work was a benchmarking OPEN ACCESSCoatings 2013, 3 269 of the mechanical oxygen permeation barrier, cytocompatibility, and microbiological properties of inorganic ~25 nm thin films, deposited by vacuum deposition techniques on 50 µm thin polyetheretherketone (PEEK) foils. Plasma-activated chemical vapor deposition (direct deposition from an ion source) was applied to deposit pure and nitrogen doped diamond-like carbon films, while physical vapor deposition (magnetron sputtering in pulsed DC mode) was used for the formation of silicon as well as titanium doped diamond-like carbon films. Silicon oxide films were deposited by radio frequency magnetron sputtering. The results indicate a strong influence of nanoporosity on the oxygen transmission rate for all coating types, while the low content of microporosity (particulates, etc.) is shown to be of lesser importance. Due to the low thickness of the foil substrates, being easily bent, the toughness as a measure of tendency to film fracture together with the elasticity index of the thin films influence the oxygen barrier. All investigated coatings are non-pyrogenic, cause no cytotoxic effects and do not influence bacterial growth.

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Antithrombogenicity of fluorinated diamond-like carbon films

Cited by 117 publications

References 17 publications

Fluorine-Incorporated Amorphous Carbon Coating Inhibits Adhesion of Blood Cells to Biomaterials

Fluorine-Incorporated Amorphous Carbon Coating Inhibits Adhesion of Blood Cells to Biomaterials

Review of Surface Modification of Nanoporous Polyethersulfone Membrane as a Dialysis Membrane

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

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