Antithrombotic effects of Danggui, Honghua and potential drug interaction with clopidogrel

Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats

“…Since in Asian countries, clopidogrel is frequently used by patients in combination with Danggui or Chuanxiong, two FA-containing herbs, which raised concerns about the efficacy and safety of such combined therapy (Chen and Xu, 2003). Our previous studies have proved that clopidogrel could enhance the antithrombotic effect of FA-containing herb (Li et al, 2009;Li and Wang, 2010). As an augmented drug effect may be caused by the elevated drug concentration, the potential change of pharmacokinetics profile of FA induced by clopidogrel in rat was investigated in the present study.…”

Protective effect of <i>Radix Bupleuri</i> extract against liver cirrhosis in rats

“…Pharmacological experiments have demonstrated that Radix Bupleuri possesses wide-reaching biological activities, including coronary artery dilation, immune system modulation, anti-inflammatory properties and analgesia [6][7][8][9][10][11]. Due to the traditional use of Radix Bupleuri in the prevention of liver cirrhosis [12], this study was performed to investigate the protective effect of Radix Bupleuri extract (RBE) against liver cirrhosis in rats.…”

Effect of <i>Salvia miltiorrhiza</i> Bge extract on liver cirrhosis in rats

“…Salvia miltiorrhiza Bge is a herb that possesses wide-reaching biological activities, including coronary artery dilation, improvement of myocardial ischemia, and modulation of the immune system, as well as antithrombotic, antioxidation, anti-aging, antihypoxic, antifatigue, anti-inflammatory, anti-hepatic fibrosis, antitumor, and analgesia effects [7][8][9][10][11][12]. As S. miltiorrhiza is used in traditional Chinese medicine to prevent liver cirrhosis [13], the current study was conducted to evaluate the anti-cirrhosis effects of the herb in rats.…”