Antithrombotic Effects of Odorless Garlic Powder Both<i>in Vitro</i>and<i>in Vivo</i>

Fukao, Hideharu; Yoshida, Hideki; Tazawa, Yoh-ichi; Hada, Takahiko

doi:10.1271/bbb.60380

Cited by 53 publications

(43 citation statements)

References 18 publications

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“…Garlic is widely accepted as a herb that through dietary intake can improve human health (61). Epidemiological studies have shown that a daily intake of garlic lowers the risk of certain cancers (25,63), and several studies have documented an antithrombotic and lipid-lowering cardiovascular effect of some of the constituents in garlic (27).…”

mentioning

confidence: 99%

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

Jakobsen

Gennip

Phipps

et al. 2012

Antimicrob Agents Chemother

388

244

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ABSTRACTIn relation to emerging multiresistant bacteria, development of antimicrobials and new treatment strategies of infections should be expected to become a high-priority research area. Quorum sensing (QS), a communication system used by pathogenic bacteria likePseudomonas aeruginosato synchronize the expression of specific genes involved in pathogenicity, is a possible drug target. Previousin vitroandin vivostudies revealed a significant inhibition ofP. aeruginosaQS by crude garlic extract. By bioassay-guided fractionation of garlic extracts, we determined the primary QS inhibitor present in garlic to be ajoene, a sulfur-containing compound with potential as an antipathogenic drug. By comprehensivein vitroandin vivostudies, the effect of synthetic ajoene towardP. aeruginosawas elucidated. DNA microarray studies of ajoene-treatedP. aeruginosacultures revealed a concentration-dependent attenuation of a few but central QS-controlled virulence factors, including rhamnolipid. Furthermore, ajoene treatment ofin vitrobiofilms demonstrated a clear synergistic, antimicrobial effect with tobramycin on biofilm killing and a cease in lytic necrosis of polymorphonuclear leukocytes. Furthermore, in a mouse model of pulmonary infection, a significant clearing of infectingP. aeruginosawas detected in ajoene-treated mice compared to a nontreated control group. This study adds to the list of examples demonstrating the potential of QS-interfering compounds in the treatment of bacterial infections.

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mentioning

confidence: 99%

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

Jakobsen

Gennip

Phipps

et al. 2012

Antimicrob Agents Chemother

388

244

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“…Garlic constituents can reduce fibrin formation and also help reduce the fibrin existing in the blood more efficiently than aspirin 42 .…”

Section: Thinning Of Bloodmentioning

confidence: 99%

A Review on Lashuna (Allium Sativum) in Pediatric Practice: Evidences From Ayurveda

Bose¹,

Ojha²

2017

Int. J. Res. Ayurveda Pharm.

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It has been always a desire by the Ayurveda fraternity to search and look for potent Ayurveda medicines which comes for several uses in relieving the diseases and many other such conditions that preserves the health and increases the longevity of human beings. One such drug is lashuna (Garlic). Garlic's prescription is found in various diseases with combination of various drugs by almost all the authors. Found to be beneficial in krimi (parasitic infestation), kushtha (skin diseases), kilasa (leukoderma), diseases caused by vata, gulma, heart disease, chronic fever, abdominal pain, constipation, anorexia, cough, edema/inflammation, durnama (piles), retention of flatus, disease caused by vata-kapha, dyspnoea, beneficial for hairs, fractures, urinary disorders, chronic coryza etc. Moreover, Kashyapa in kalpasthan "Lashuna Kalpadhyay" (chapter 2?) has described in detail and vividly about the pharmaceutical preparations of garlic for the benefit of mankind. This shows that the lashuna is a wonder drug even in Ayurveda pediatric practices also and is important for many diseases and rejuvenating conditions. Thus, the goal of discovering such a potent drug which is already known to the common man, easily available, economic etc., becomes successful, if and only if the common man finds its use in daily life after knowing its properly. The paper provides detailed description of the evidences regarding the use of lashuna (Allium sativum) in pediatric practice from Ayurveda.

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“…Otro estudio con ajo en polvo ha demostrado que este favorece la actividad fibrinolítica además de suprimir el sistema de coagulación previniendo así la formación de trombos (20). Estos resultados se han corroborado en otro trabajo, en el cual se demuestra que el extracto alcohólico de ajo es un potente inhibidor de la agregación plaquetaria (21).…”

Section: Efecto Sobre La Tensión Arterial Y Endotelio Vascularunclassified

Ajo y riesgo cardiovascular

Luis

Aller

2008

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl ajo Allium sativum, perteneciente a la familia botánica de las liliáceas forma parte del género Allium, al que pertenecen la cebolla, los puerros o ciboulette. Su olor, penetrante y persistente, constituye su característica más notable. Esta planta es una hierba perenne resistente de 20 a 40 centímetros de altura, hojas alargadas, y flores blancas o rosadas, presenta un bulbo o "cabeza", compuesto por bulbillos o "dientes", dispuestos alrededor del tallo y envueltos en una membrana suave y sedosa.El ajo es el más picante de todos los Allium y ha sido ampliamente utilizado en muchas culturas para finalidades medicinales y culinarias, estando ampliamente introducido en nuestra dieta mediterránea. El ajo es una de las plantas curativas más antiguas de la que tenemos referencia, ha sido cultivado por los seres humanos como planta de alimento desde hace más de 10.000 años. El ajo nace en el antiguo Turkestán (límite entre China y Afganistán e Irán) desde donde es exportado a China, India, norte de Europa y las márgenes del Mediterráneo. El Codex Ebres, un papiro médico que data del 1550 a. C. contiene 22 menciones sobre el ajo y su aplicación en el control de cardiopatía, mordeduras parásitos intestinales y tumores. Los principales componentes activos del ajo son los amino- [0212-7199 (2008) RESUMENEl ajo es una de las plantas curativas más antiguas de la que tenemos referencia. En el presente trabajo, revisaremos las evidencias existentes sobre el consumo de ajo y el riesgo cardiovascular, analizando su papel sobre el perfil lipídico, el endotelio vascular y la agregación plaquetaria. El consumo regular de 5 g de ajo crudo dos veces al día durante 42 días disminuye los niveles de colesterol total y triglicéridos, no obstante la mayor parte de los estudios realizados en el campo de os lípidos han sido llevados a cabo en animales. En modelos animales (perros y ratas) se ha demostrado los efectos hipotensores del ajo de manera dosis dependiente. Algunos trabajos han demostrado que el ajo activa la fibrinolisis, además de suprimir el sistema de coagulación previniendo así la formación de trombos. Estos resultados se han corroborado en otro trabajo, en el cual se demuestra que el extracto alcohólico de ajo es un potente inhibidor de la agregación plaquetaria.En resumen, los efectos del ajo sobre la disminución del riesgo cardiovascular son importantes. No obstante los estudios en humanos son escasos y todavía falta por demostrar que estos efectos disminuyan los eventos cardiovasculares así como la cantidad necesaria de ajo para obtener estos beneficios.

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Antithrombotic Effects of Odorless Garlic Powder Bothin Vitroandin Vivo

Cited by 53 publications

References 18 publications

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

A Review on Lashuna (Allium Sativum) in Pediatric Practice: Evidences From Ayurveda

Ajo y riesgo cardiovascular

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